دورية أكاديمية
أعرض في EDS

Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks.

التفاصيل البيبلوغرافية
العنوان: Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks.
المؤلفون: Li HH; National Mosquito-Borne Disease Control Research Center, NHRI, Miaoli, 350401, Taiwan; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, 92093, USA., Su MP; Graduate School of Science, Nagoya University, Nagoya, 464-8602, Japan; Institute for Advanced Research, Nagoya University, Nagoya, 464-8601, Japan., Wu SC; National Mosquito-Borne Disease Control Research Center, NHRI, Miaoli, 350401, Taiwan; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, 10048, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 10021, Taiwan., Tsou HH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, 350401, Taiwan; Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, 40402, Taiwan., Chang MC; Department of Life Science & Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan., Cheng YC; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, 350401, Taiwan., Tsai KN; Institute of Molecular and Genomic Medicine, NHRI, Miaoli, 350401, Taiwan., Wang HW; National Mosquito-Borne Disease Control Research Center, NHRI, Miaoli, 350401, Taiwan; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan., Chen GH; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, 300, Taiwan., Tang CK; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan; Program of Plant Protection and Health, Academy of Circular Economy, National Chung Hsing University, Taichung, 402202, Taiwan., Chung PJ; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan., Tsai WT; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan., Huang LR; Institute of Molecular and Genomic Medicine, NHRI, Miaoli, 350401, Taiwan., Yueh YA; Institute of Biotechnology and Pharmaceutical Research, NHRI, Miaoli, 350401, Taiwan., Chen HW; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan., Pan CY; Department of Health, Kaohsiung City Government, Kaohsiung, 800852, Taiwan., Akbari OS; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, 92093, USA., Chang HH; Department of Life Science & Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan., Yu GY; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan., Marshall JM; Divisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, CA, 94720, USA., Chen CH; National Mosquito-Borne Disease Control Research Center, NHRI, Miaoli, 350401, Taiwan; National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli, 350401, Taiwan. Electronic address: chunhong@gmail.com.
المصدر: EBioMedicine [EBioMedicine] 2023 Aug; Vol. 94, pp. 104723. Date of Electronic Publication: 2023 Jul 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2014]-
مواضيع طبية MeSH: Dengue Virus* , Dengue*/epidemiology , Aedes*, Humans ; Animals ; Mice ; Disease Outbreaks ; Mosquito Vectors
مستخلص: Background: Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible.
Methods: We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population.
Findings: Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggest that this supplemental transmission route could result in larger outbreaks which peak sooner.
Interpretation: The potential of dengue transmission routes independent of midgut viral replication has implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes.
Funding: This study was funded by grants from the National Health Research Institutes, Taiwan (04D2-MMMOST02), the Human Frontier Science Program (RGP0033/2021), the National Institutes of Health (1R01AI143698-01A1, R01AI151004 and DP2AI152071) and the Ministry of Science and Technology, Taiwan (MOST104-2321-B-400-016).
Competing Interests: Declaration of interests OSA. is a founder of Agragene, Inc. with equity interest and a founder of Synvect with equity interest. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. All remaining authors declare no competing interests.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
معلومات مُعتمدة: DP2 AI152071 United States AI NIAID NIH HHS; R01 AI143698 United States AI NIAID NIH HHS; R01 AI151004 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Aedes aegypti mosquito; Animal models of dengue virus; Dengue transmission; Mathematical modelling of disease outbreak
تواريخ الأحداث: Date Created: 20230724 Date Completed: 20230814 Latest Revision: 20230814
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10382859
DOI: 10.1016/j.ebiom.2023.104723
PMID: 37487418
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-3964
DOI:10.1016/j.ebiom.2023.104723