دورية أكاديمية
Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death.
العنوان: | Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death. |
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المؤلفون: | Gibbs DC; Department of Dermatology, Emory University, Atlanta, GA, USA., Thomas NE; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA., Kanetsky PA; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Luo L; Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA., Busam KJ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cust AE; Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, NSW, Australia.; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia., Anton-Culver H; Department of Epidemiology, University of California, Irvine, CA, USA., Gallagher RP; Cancer Control Research, British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada., Zanetti R; Center for Cancer Prevention, Piedmont Cancer Registry, Torino, Italy.; Fondo Elena Moroni for Oncology, Torino, Italy.; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA., Rosso S; Center for Cancer Prevention, Piedmont Cancer Registry, Torino, Italy.; Fondo Elena Moroni for Oncology, Torino, Italy.; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA., Sacchetto L; Center for Cancer Prevention, Piedmont Cancer Registry, Torino, Italy.; Fondo Elena Moroni for Oncology, Torino, Italy.; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA., Edmiston SN; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA., Conway K; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Epidemiology, Gillings Global School of Public Health, University of North Carolina, Chapel Hill, NC, USA., Ollila DW; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Surgery, University of North Carolina, Chapel Hill, NC, USA., Begg CB; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Berwick M; Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA., Ward SV; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; School of Population and Global Health, The University of Western Australia, Perth, WA, Australia., Orlow I; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. |
المصدر: | JNCI cancer spectrum [JNCI Cancer Spectr] 2023 Aug 31; Vol. 7 (5). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101721827 Publication Model: Print Cited Medium: Internet ISSN: 2515-5091 (Electronic) Linking ISSN: 25155091 NLM ISO Abbreviation: JNCI Cancer Spectr Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press, [2017]- |
مواضيع طبية MeSH: | Melanoma*/genetics , Vitamin D-Binding Protein*/genetics , Vitamin D-Binding Protein*/metabolism, Humans ; Polymorphism, Single Nucleotide ; Vitamin D ; Melanoma, Cutaneous Malignant |
مستخلص: | Background: It is unclear whether genetic variants affecting vitamin D metabolism are associated with melanoma prognosis. Two functional missense variants in the vitamin D-binding protein gene (GC), rs7041 and rs4588, determine 3 common haplotypes, Gc1s, Gc1f, and Gc2, of which Gc1f may be associated with decreased all-cause death among melanoma patients based on results of a prior study, but the association of Gc1f with melanoma-specific death is unclear. Methods: We investigated the association of the Gc1s, Gc1f, and Gc2 haplotypes with melanoma-specific and all-cause death among 4490 individuals with incident, invasive primary melanoma in 2 population-based studies using multivariable Cox-proportional hazards regression. Results: In the pooled analysis of both datasets, the patients with the Gc1f haplotype had a 37% lower risk of melanoma-specific death than the patients without Gc1f (hazard ratio [HR] = 0.63, 95% confidence interval [CI] = 0.47 to 0.83, P = .001), with adjustments for age, sex, study center, first- or higher-order primary melanoma, tumor site, pigmentary phenotypes, and Breslow thickness. Associations were similar in both studies. In pooled analyses stratified by Breslow thickness, the corresponding melanoma-specific death HRs for those patients with the Gc1f haplotype compared with those without Gc1f were 0.89 (95% CI = 0.63 to 1.27) among participants with tumor Breslow thickness equal to or less than 2.0 mm and 0.40 (95% CI = 0.25 to 0.63) among participants with tumor Breslow thickness greater than 2.0 mm (Pinteraction = .003). Conclusions: Our findings suggest that individuals with the GC haplotype Gc1f may have a lower risk of dying from melanoma-specifically from thicker, higher-risk melanoma-than individuals without this Gc1f haplotype. (© The Author(s) 2023. Published by Oxford University Press.) |
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معلومات مُعتمدة: | P30 ES010126 United States ES NIEHS NIH HHS; P30ES010126 United States ES NIEHS NIH HHS; R01 CA233524 United States CA NCI NIH HHS; U01 CA083180 United States CA NCI NIH HHS; R01CA233524 United States CA NCI NIH HHS; P30 CA016086 United States CA NCI NIH HHS; R03 CA173806 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; P01 CA206980 United States CA NCI NIH HHS; R03 CA125829 United States CA NCI NIH HHS; R01 CA112243 United States CA NCI NIH HHS; R01 CA098438 United States CA NCI NIH HHS; R01 CA112524 United States CA NCI NIH HHS |
المشرفين على المادة: | 1406-16-2 (Vitamin D) 0 (Vitamin D-Binding Protein) 0 (GC protein, human) |
تواريخ الأحداث: | Date Created: 20230726 Date Completed: 20230918 Latest Revision: 20231213 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10496570 |
DOI: | 10.1093/jncics/pkad051 |
PMID: | 37494457 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2515-5091 |
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DOI: | 10.1093/jncics/pkad051 |