دورية أكاديمية
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Adrenal Anion Channels: New Roles in Zona Glomerulosa Physiology and in the Pathophysiology of Primary Aldosteronism.

التفاصيل البيبلوغرافية
العنوان: Adrenal Anion Channels: New Roles in Zona Glomerulosa Physiology and in the Pathophysiology of Primary Aldosteronism.
المؤلفون: Stölting G; Center of Functional Genomics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Scholl UI; Center of Functional Genomics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. ute.scholl@bih-charite.de.
المصدر: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2024; Vol. 283, pp. 59-79.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902231 Publication Model: Print Cited Medium: Print ISSN: 0171-2004 (Print) Linking ISSN: 01712004 NLM ISO Abbreviation: Handb Exp Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Zona Glomerulosa* , Hyperaldosteronism*/genetics, Animals ; Aldosterone ; Ion Channels ; Signal Transduction
مستخلص: The mineralocorticoid aldosterone is produced in the zona glomerulosa of the adrenal cortex. Its synthesis is regulated by the serum concentrations of the peptide hormone angiotensin II and potassium. The primary role of aldosterone is to control blood volume and electrolytes. The autonomous production of aldosterone (primary aldosteronism, PA) is considered the most frequent cause of secondary hypertension. Aldosterone-producing adenomas and (micro-)nodules are frequent causes of PA and often carry somatic mutations in ion channels and transporters. Rare familial forms of PA are due to germline mutations. Both somatic and germline mutations in the chloride channel gene CLCN2, encoding ClC-2, have been identified in PA. Clinical findings and results from cell culture and animal models have advanced our knowledge about the role of anions in PA. The zona glomerulosa of the adrenal gland has now been firmly established as a tissue in which anions play a significant role for signaling. In this overview, we aim to summarize the current knowledge and highlight novel concepts as well as open questions.
(© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
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فهرسة مساهمة: Keywords: Aldosterone; CLCN2; Chloride channel; ClC-2; Oscillation
المشرفين على المادة: 4964P6T9RB (Aldosterone)
0 (Ion Channels)
تواريخ الأحداث: Date Created: 20230726 Date Completed: 20240105 Latest Revision: 20240105
رمز التحديث: 20240105
DOI: 10.1007/164_2023_680
PMID: 37495852
قاعدة البيانات: MEDLINE
الوصف
تدمد:0171-2004
DOI:10.1007/164_2023_680