دورية أكاديمية
Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood.
| العنوان: | Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood. |
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| المؤلفون: | Andronescu LR; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, 21201, USA., Buchwald AG; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, 21201, USA., Sharma A; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, 21201, USA., Bauleni A; Malaria Alert Center, Kamuzu University of Health Sciences, Blantyre, Malawi., Mawindo P; Malaria Alert Center, Kamuzu University of Health Sciences, Blantyre, Malawi., Liang Y; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, 21201, USA., Gutman JR; Malaria Branch, Centers for Disease Control and Prevention, Atlanta, 30333, USA., Mathanga DP; Malaria Alert Center, Kamuzu University of Health Sciences, Blantyre, Malawi., Chinkhumba J; Malaria Alert Center, Kamuzu University of Health Sciences, Blantyre, Malawi., Laufer MK; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, 21201, USA. mlaufer@som.umaryland.edu. |
| المصدر: | Malaria journal [Malar J] 2023 Jul 26; Vol. 22 (1), pp. 217. Date of Electronic Publication: 2023 Jul 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2002- |
| مواضيع طبية MeSH: | Malaria, Falciparum*/complications , Malaria, Falciparum*/epidemiology , Malaria*/complications , Anemia*/epidemiology , Anemia*/complications, Humans ; Infant ; Plasmodium falciparum ; Hemoglobins |
| مستخلص: | Background: Infants under 6 months of age are often excluded from malaria surveillance and observational studies. The impact of malaria during early infancy on health later in childhood remains unknown. Methods: Infants from two birth cohorts in Malawi were monitored at quarterly intervals and whenever they were ill from birth through 24 months for Plasmodium falciparum infections and clinical malaria. Poisson regression and linear mixed effects models measured the effect of exposure to malaria in infancy on subsequent malaria incidence, weight-for-age z-scores (WAZ), and haemoglobin concentrations after 6 months. Results: Infants with at least one P. falciparum infection during their first 6 months had increased incidence ratio (IRR) of P. falciparum infection (IRR = 1.27, 95% CI, 1.06-1.52) and clinical malaria (IRR = 2.37, 95% CI, 2.02-2.80) compared to infants without infection. Infants with clinical malaria had increased risk of P. falciparum infection incidence between 6 and 24 months (IRR = 1.64, 95% CI, 1.38-1.94) and clinical malaria (IRR = 1.85, 95% CI, 1.48-2.32). Exposure to malaria was associated with lower WAZ over time (p = 0.02) and lower haemoglobin levels than unexposed infants at every time interval (p = 0.02). Conclusions: Infants experiencing malaria infection or clinical malaria are at increased risk of subsequent infection and disease, have poorer growth, and lower haemoglobin concentrations. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | K24 AI114996 United States AI NIAID NIH HHS; R21AI121990 National Institute of Allergy and Infectious Diseases |
| فهرسة مساهمة: | Keywords: Hemoglobin; Incidence; Infant development; Infants; Malaria |
| المشرفين على المادة: | 0 (Hemoglobins) |
| تواريخ الأحداث: | Date Created: 20230726 Date Completed: 20230728 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC10369742 |
| DOI: | 10.1186/s12936-023-04646-8 |
| PMID: | 37496052 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1475-2875 |
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| DOI: | 10.1186/s12936-023-04646-8 |