دورية أكاديمية
أعرض في EDS

The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes.

التفاصيل البيبلوغرافية
العنوان: The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes.
المؤلفون: Buratini J; Biogenesi, Reproductive Medicine Centre, Monza, Italy. jburatini@eugin.it.; Clinica EUGIN, Milan, Italy. jburatini@eugin.it.; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University, Botucatu, SP, Brazil. jburatini@eugin.it., Moutier C; Biogenesi, Reproductive Medicine Centre, Monza, Italy., Guglielmo MC; Clinica EUGIN, Milan, Italy., Turchi D; Biogenesi, Reproductive Medicine Centre, Monza, Italy., Webb R; University of Nottingham, Nottinghamshire, UK., De Ponti E; Medical Physics, Fondazione IRCCS San Gerardo dei Tintori Monza, Monza, Italy., Renzini MM; Biogenesi, Reproductive Medicine Centre, Monza, Italy.; Clinica EUGIN, Milan, Italy., Canto MD; Biogenesi, Reproductive Medicine Centre, Monza, Italy.; Clinica EUGIN, Milan, Italy.
المصدر: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2023 Oct; Vol. 40 (10), pp. 2375-2384. Date of Electronic Publication: 2023 Jul 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7330 (Electronic) Linking ISSN: 10580468 NLM ISO Abbreviation: J Assist Reprod Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004- >: Amsterdam : Springer
Original Publication: New York : Plenum Press, c1992-
مواضيع طبية MeSH: Sperm Injections, Intracytoplasmic* , Ovulation Induction*, Pregnancy ; Female ; Humans ; Pregnancy Rate ; Retrospective Studies ; Oocytes ; Follicle Stimulating Hormone/pharmacology ; Fertilization in Vitro
مستخلص: Purpose: To assess the effects of oocyte central granularity and its underlying endocrine environment on developmental competence of dysmorphic and morphologically normal oocytes.
Methods: Retrospective cohort study including 1,082 patients undergoing autologous ICSI cycles. Of these, 211 patients provided 602 oocytes with central granularity (CG) and 427 morphologically normal cycle companion oocytes (NCG). The remaining 871 patients provided only morphologically normal oocytes in cycles not yielding dysmorphic oocytes (N). Patient profile associated with CG was characterized, and fertilization rates, early morphokinetics and live birth rates were compared between N, CG and NCG groups. Patient characteristics associated with implantation and delivery performance of CG-derived embryos were assessed.
Results: CG was associated with higher maternal age, basal FSH concentrations and total FSH dose, but with lower circulating AMH (p ≤ 0.035). Fertilization rates were reduced and early morphokinetic parameters were delayed in CG (p < 0.025) and NCG (p < 0.05) groups as compared to the N group. Embryos derived from CG oocytes achieved a markedly lower live birth rate (14.9%) as compared to those derived from NCG (36.8%; p = 0.03) and N oocytes (29.8%; p = 0.002). The negative relationship between CG and live birth was confirmed by a multivariate analysis controlling for potential confounders (OR:2.59, IC:1.27-5.31; P = 0.009). Implantation and delivery rates following transfers of CG-derived embryos were inversely associated with maternal age.
Conclusion: CG oocytes, but not their morphologically normal cycle companions, have severely compromised developmental competence. Maternal age should be a key parameter in deciding whether or not to utilize CG oocytes in ICSI cycles.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Fertilization; Live birth; Maternal age; Morphokinetics; Oocyte central granularity
المشرفين على المادة: 9002-68-0 (Follicle Stimulating Hormone)
تواريخ الأحداث: Date Created: 20230727 Date Completed: 20230918 Latest Revision: 20230922
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10504199
DOI: 10.1007/s10815-023-02895-9
PMID: 37501005
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7330
DOI:10.1007/s10815-023-02895-9