دورية أكاديمية
أعرض في EDS

Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study.

التفاصيل البيبلوغرافية
العنوان: Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study.
المؤلفون: Johansen I; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, Norway. Ingunn.johansen@hiof.no.; Institute of Health and Society, University of Oslo, Oslo, Norway. Ingunn.johansen@hiof.no., Småstuen MC; Department of Health Science, Oslo Metropolitan University, Oslo, Norway., Løkkeberg ST; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, Norway., Kristensen VA; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway., Høivik ML; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund C; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Olsen B; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Strande V; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Department of Gastroenterology, Lovisenberg Diaconal Hospital, Oslo, Norway., Huppertz-Hauss G; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway., Aabrekk TB; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway., Bengtson MB; Department of Gastroenterology, Vestfold Hospital Trust, Tønsberg, Norway., Ricanek P; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Detlie TE; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway., Frigstad SO; Department of Medicine, Vestre Viken Hospital Trust, Baerum Hospital, Baerum, Norway., Jelsness-Jørgensen LP; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, Norway.; Department of Gastroenterology, Østfold Hospital Trust, Fredrikstad, Norway., Opheim R; Institute of Health and Society, University of Oslo, Oslo, Norway.; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2023 Jul 27; Vol. 23 (1), pp. 255. Date of Electronic Publication: 2023 Jul 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Inflammatory Bowel Diseases*/complications , Inflammatory Bowel Diseases*/epidemiology , Vitamin D Deficiency* , Colitis, Ulcerative*/complications, Humans ; Adolescent ; Syndrome ; Prospective Studies ; Surveys and Questionnaires
مستخلص: Background: Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine the prevalence of symptoms and explore symptom clusters and possible associations between symptom clusters and socio-demographic and clinical variables in patients newly diagnosed with inflammatory bowel disease.
Methods: The IBSEN III study is a prospective population-based inception cohort of patients with inflammatory bowel disease. This study used patient data from the three largest hospitals in the study catchment area. The Memorial Symptom Assessment Scale was used to assess the prevalence of symptoms. Symptom clusters were identified using principal component analysis. Possible associations between socio-demographic and clinical variables and symptom cluster membership were estimated using regression analysis.
Results: Of the 573 patients (age, ≥18 years) diagnosed with inflammatory bowel disease, 350 (61.1%) completed the questionnaire (responders). Eleven symptoms were reported by >50% of the responders. The three most prevalent symptoms were bloating (84%), drowsiness (81%), and lack of energy (81%). Three symptom clusters were identified: psychological (56% of the patients), impaired energy (28%), and physical (16%) clusters. Multinomial regression analysis revealed that vitamin D deficiency was significantly associated with the impaired energy cluster (odds ratio=2.49, 95% confidence interval [1.00-6.2], p=0.05).
Conclusions: We found high symptom prevalence in patients newly diagnosed with inflammatory bowel disease. Three distinct symptom clusters were identified, and the psychological cluster includes >50% of the patients. Vitamin D deficiency is the only factor associated with cluster membership, namely the impaired energy cluster.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: CD; Crohn`s disease; IBD; Inflammatory bowel disease; Symptom clusters; Symptoms; UC; Ulcerative colitis
تواريخ الأحداث: Date Created: 20230727 Date Completed: 20230731 Latest Revision: 20230919
رمز التحديث: 20230919
مُعرف محوري في PubMed: PMC10373240
DOI: 10.1186/s12876-023-02889-y
PMID: 37501083
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-023-02889-y