دورية أكاديمية
أعرض في EDS

Treatment of Secondary Hyperparathyroidism and Posttransplant Tertiary Hyperparathyroidism.

التفاصيل البيبلوغرافية
العنوان: Treatment of Secondary Hyperparathyroidism and Posttransplant Tertiary Hyperparathyroidism.
المؤلفون: Egan CE; Department of Surgery, Weill Cornell Medicine, New York, New York. Electronic address: Cee9007@nyp.org., Qazi M; Department of Surgery, Weill Cornell Medicine, New York, New York., Lee J; Department of Surgery, Weill Cornell Medicine, New York, New York., Lee-Saxton YJ; Department of Surgery, Weill Cornell Medicine, New York, New York., Greenberg JA; Department of Surgery, Weill Cornell Medicine, New York, New York., Beninato T; Department of Surgery Rutgers-Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey., Zarnegar R; Department of Surgery, Weill Cornell Medicine, New York, New York., Fahey TJ 3rd; Department of Surgery, Weill Cornell Medicine, New York, New York., Finnerty BM; Department of Surgery, Weill Cornell Medicine, New York, New York.
المصدر: The Journal of surgical research [J Surg Res] 2023 Nov; Vol. 291, pp. 330-335. Date of Electronic Publication: 2023 Jul 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0376340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8673 (Electronic) Linking ISSN: 00224804 NLM ISO Abbreviation: J Surg Res Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Academic Press
Original Publication: Philadelphia [etc.]
مواضيع طبية MeSH: Hyperparathyroidism, Secondary*/etiology , Hyperparathyroidism, Secondary*/surgery, Humans ; Calcium ; Cinacalcet/therapeutic use ; Parathyroid Hormone ; Parathyroidectomy/adverse effects ; Renal Dialysis/adverse effects ; Retrospective Studies
مستخلص: Introduction: Secondary hyperparathyroidism (sHPT) is prevalent in dialysis patients and can lead to tertiary hyperparathyroidism (tHPT) after kidney transplantation. We aimed to assess the association of pretransplant sHPT treatment on posttransplant outcomes.
Methods: We reviewed kidney transplant patients treated with parathyroidectomy or cinacalcet for sHPT. We compared patients biochemical and clinical parameters, and outcomes based on sHPT treatment.
Results: A total of 41 patients were included: 18 patients underwent parathyroidectomy and 23 patients received cinacalcet prior to transplantation. There were no significant differences between demographics, comorbidities, allograft characteristics or pre-sHPT intervention parathyroid hormone (PTH) and calcium levels. Patients that underwent parathyroidectomy were on dialysis for longer, although not significantly (71.9 versus 42.3 mo, P = 0.051). At time of transplantation, patients treated by parathyroidectomy had increased rates of controlled sHPT (88.9%; 16/18 versus 47.8%; 11/23, P = 0.008). Patients treated by parathyroidectomy had decreased development of tHPT (5.9%; 1/17; versus 42.1%; 8/19, P = 0.020) as well as decreased rates of posttransplant treatment with cinacalcet (11.1%; 2/18 versus 52.2%; 12/23, P = 0.008). Three patients treated with cinacalcet underwent parathyroidectomy after transplantation. Median PTH after transplant remained lower in patients treated by parathyroidectomy prior to transplant compared to those treated with cinacalcet (60.7 [interquartile range 39.7-133.4] versus 170.0 [interquartile range 128.4-292.7], P = 0.001). Allograft function and survival were similar for parathyroidectomy and cinacalcet, with median follow-up after transplantation of 56.7 and 34.2 mo, respectively.
Conclusions: sHPT treated by parathyroidectomy is associated with controlled PTH levels at transplantation and decreased rates of tHPT. Long-term outcomes should be studied on a larger scale.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Cinacalcet; Kidney transplantation; Parathyroidectomy; Secondary hyperparathyroidism; Tertiary hyperparathyroidism
المشرفين على المادة: SY7Q814VUP (Calcium)
UAZ6V7728S (Cinacalcet)
0 (Parathyroid Hormone)
تواريخ الأحداث: Date Created: 20230728 Date Completed: 20231019 Latest Revision: 20231019
رمز التحديث: 20240628
DOI: 10.1016/j.jss.2023.06.031
PMID: 37506432
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-8673
DOI:10.1016/j.jss.2023.06.031