دورية أكاديمية
أعرض في EDS

The Gut Microbiota Differ in Exclusively Breastfed and Formula-Fed United States Infants and are Associated with Growth Status.

التفاصيل البيبلوغرافية
العنوان: The Gut Microbiota Differ in Exclusively Breastfed and Formula-Fed United States Infants and are Associated with Growth Status.
المؤلفون: Odiase E; Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Virginia, Charlottesville, VA, 22904, USA., Frank DN; Division of Infectious Disease, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Young BE; University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Robertson CE; Division of Infectious Disease, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Kofonow JM; Division of Infectious Disease, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Davis KN; Section of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Berman LM; Section of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Krebs NF; Section of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Tang M; Section of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: minghua.tang@cuanschutz.edu.
المصدر: The Journal of nutrition [J Nutr] 2023 Sep; Vol. 153 (9), pp. 2612-2621. Date of Electronic Publication: 2023 Jul 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas
مواضيع طبية MeSH: Breast Feeding* , Gastrointestinal Microbiome*, Female ; Humans ; Infant ; Milk, Human ; Infant Formula ; Infant Nutritional Physiological Phenomena ; Feces/microbiology
مستخلص: Background: Evidence regarding the effects of infant feeding type (exclusive breastfeeding compared with exclusive formula feeding) on the gut microbiota and how it impacts infant growth status is limited.
Objectives: The primary objective was to compare gut microbiota by feeding type and characterize the associations between gut microbiota and infant growth status.
Methods: Stool samples from healthy, full-term infants (4-5 mo-old) who were either exclusively breastfed (BF) or exclusively formula-fed (FF) in Denver, CO, United States were collected, and fecal 16S ribosomal ribonucleic acid gene-based profiling was conducted. Length and weight were measured at the time of stool collection. Length-for-age z-score, weight-for-age z-scores (WAZ), and weight-for-length z-scores were calculated based on the World Health Organization standards. Associations between gut microbial taxa and anthropometric z-scores were assessed by Spearman's rank correlation test.
Results: A total of 115 infants (BF n = 54; FF n = 61) were included in this study. Feeding type (BF compared with FF) was the most significant tested variable on gut microbiota composition (P < 1 × 10-⁶), followed by mode of delivery and race. Significant differences were observed in α-diversity, β-diversity, and relative abundances of individual taxa between BF and FF. BF infants had lower α-diversity than FF infants. Abundances of Bifidobacterium and Lactobacillus were greater in the breastfeeding group. FF infants had a higher relative abundance of unclassified Ruminococcaceae (P < 0.001), which was associated with a higher WAZ (P < 0.001) and length-for-age z-score (P < 0.01). Lactobacillus was inversely associated with WAZ (P < 0.05).
Conclusions: Feeding type is the main driver of gut microbiota differences in young infants. The gut microbiota differences based on feeding type (exclusive breast- or formula feeding) were associated with observed differences in growth status. This trial was registered at clinicaltrials.gov as NCT02142647, NCT01693406, and NCT04137445.
(Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.)
References: Nutrients. 2021 Nov 23;13(12):. (PMID: 34959752)
Am J Clin Nutr. 1993 Feb;57(2):140-5. (PMID: 8424381)
Matern Child Health J. 2017 Jun;21(6):1367-1376. (PMID: 28138825)
Sci Rep. 2019 Jun 3;9(1):8167. (PMID: 31160673)
Science. 2016 Feb 19;351(6275):854-7. (PMID: 26912894)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
Oncogene. 2022 Feb;41(9):1269-1280. (PMID: 35087236)
Nutr Res Pract. 2015 Jun;9(3):242-8. (PMID: 26060535)
Gut. 2007 May;56(5):661-7. (PMID: 17047098)
Nutrients. 2017 Jul 19;9(7):. (PMID: 28753958)
Bioinformatics. 2011 Aug 15;27(16):2194-200. (PMID: 21700674)
BMC Gastroenterol. 2016 Jul 30;16(1):86. (PMID: 27475754)
Clin Infect Dis. 2018 Sep 28;67(8):1237-1246. (PMID: 29659737)
FASEB J. 2021 Jun;35(6):e21682. (PMID: 34042210)
Microbiome. 2014 May 05;2:15. (PMID: 24910773)
Semin Immunopathol. 2015 Jan;37(1):47-55. (PMID: 25420450)
Sci Rep. 2020 Sep 25;10(1):15792. (PMID: 32978424)
Science. 2016 Feb 19;351(6275):. (PMID: 26912898)
PLoS One. 2016 Jun 30;11(6):e0158498. (PMID: 27362264)
J Bacteriol. 1991 Jan;173(2):697-703. (PMID: 1987160)
Nat Commun. 2018 Oct 9;9(1):4169. (PMID: 30301893)
Front Microbiol. 2017 Nov 15;8:2224. (PMID: 29187837)
Bioinformatics. 2012 Jul 15;28(14):1823-9. (PMID: 22556368)
Appl Environ Microbiol. 2011 May;77(10):3219-26. (PMID: 21421784)
Ecol Lett. 2011 Jan;14(1):19-28. (PMID: 21070562)
mBio. 2019 Jan 29;10(1):. (PMID: 30696735)
Front Microbiol. 2014 Apr 29;5:190. (PMID: 24808896)
JAMA Pediatr. 2019 Dec 1;173(12):e193319. (PMID: 31609438)
Genome Res. 1998 Mar;8(3):186-94. (PMID: 9521922)
J Clin Med. 2021 Jan 25;10(3):. (PMID: 33504109)
Nat Commun. 2018 Jan 10;9(1):141. (PMID: 29321519)
Sci Rep. 2019 Feb 21;9(1):2434. (PMID: 30792412)
J Perinatol. 2020 Jul;40(7):1066-1074. (PMID: 31992818)
Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286)
JAMA Pediatr. 2018 Jul 2;172(7):e181161. (PMID: 29868719)
Microorganisms. 2021 Apr 24;9(5):. (PMID: 33923278)
Microbiome. 2017 Mar 9;5(1):31. (PMID: 28274256)
MMWR Recomm Rep. 2010 Sep 10;59(RR-9):1-15. (PMID: 20829749)
J Hum Lact. 2021 Nov;37(4):703-713. (PMID: 32926654)
BMC Bioinformatics. 2009 Oct 29;10:362. (PMID: 19874596)
Proc Natl Acad Sci U S A. 1985 Oct;82(20):6955-9. (PMID: 2413450)
Front Endocrinol (Lausanne). 2017 Dec 13;8:349. (PMID: 29326657)
N Engl J Med. 2021 Apr 22;384(16):1517-1528. (PMID: 33826814)
Am J Clin Nutr. 2020 Jun 1;111(6):1190-1202. (PMID: 32330237)
Sci Transl Med. 2022 Apr 13;14(640):eabk1107. (PMID: 35417188)
J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):216-25. (PMID: 19179885)
Sci Rep. 2017 Aug 30;7(1):10097. (PMID: 28855672)
Physiol Genomics. 2019 Aug 1;51(8):368-378. (PMID: 31226006)
Nutrients. 2020 Mar 29;12(4):. (PMID: 32235348)
Genome Res. 1998 Mar;8(3):175-85. (PMID: 9521921)
Br J Nutr. 2014 May;111(9):1602-10. (PMID: 24411010)
J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):77-84. (PMID: 20479681)
Bioinformatics. 2013 Dec 1;29(23):3100-1. (PMID: 24021386)
PLoS One. 2013 Jul 02;8(7):e67019. (PMID: 23843979)
معلومات مُعتمدة: P30 DK048520 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: breastfeeding; growth status; gut microbiota; infant formula; mode of feeding
سلسلة جزيئية: ClinicalTrials.gov NCT04137445; NCT02142647; NCT01693406
تواريخ الأحداث: Date Created: 20230728 Date Completed: 20230911 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC10517231
DOI: 10.1016/j.tjnut.2023.07.009
PMID: 37506974
قاعدة البيانات: MEDLINE
الوصف
تدمد:1541-6100
DOI:10.1016/j.tjnut.2023.07.009