دورية أكاديمية
Omega-3 Polyunsaturated Fatty Acids Alleviate Intestinal Barrier Dysfunction in Obstructive Jaundice Rats.
| العنوان: | Omega-3 Polyunsaturated Fatty Acids Alleviate Intestinal Barrier Dysfunction in Obstructive Jaundice Rats. |
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| المؤلفون: | Zhang C; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China., Yin Z; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China., Hu F; Clinical Medicine Laboratory, Binzhou Medical University Hospital, Binzhou, 256603, Shandong, China., Lin X; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China., Guan Q; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China., Zhang F; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China., Zhang X; Department of General Surgery, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, 256603, Shandong, China. zhangxingyuann@hotmail.com. |
| المصدر: | Molecular biotechnology [Mol Biotechnol] 2024 Aug; Vol. 66 (8), pp. 1954-1960. Date of Electronic Publication: 2023 Jul 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Cham] : Springer Original Publication: Totowa, NJ : Humana Press, c1994- |
| مواضيع طبية MeSH: | Jaundice, Obstructive*/metabolism , Jaundice, Obstructive*/drug therapy , Jaundice, Obstructive*/pathology , Fatty Acids, Omega-3*/pharmacology , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/drug effects , Intestinal Mucosa*/pathology , Apoptosis*/drug effects , Tight Junction Proteins*/metabolism , Tight Junction Proteins*/genetics, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal ; Tight Junctions/metabolism ; Tight Junctions/drug effects ; Cytokines/metabolism ; Intestines/drug effects ; Intestines/pathology |
| مستخلص: | Obstructive jaundice (OJ) can cause multiple pathophysiological consequences including intestinal barrier dysfunction. Omega-3 has been indicated to have a promising therapeutic effect on OJ. This study aimed to further investigate the functions of omega-3 on OJ-induced intestinal injury. A rat OJ model was established by bile duct ligation with or without omega-3 administration. ELISA was utilized for measuring serum levels of inflammatory cytokines. Hematoxylin-eosin staining and TUNEL staining were employed for detecting the morphological changes and cell apoptosis in rat intestine. Western blotting was utilized for evaluating expression of tight junction proteins in the intestinal tissues. Omgea-3 offset the reduction in body weight of OJ rats. Omega-3 alleviated inflammatory response, pathological damages and cell apoptosis in the intestine of OJ rats. Additionally, omega-3 enhanced levels of tight junction proteins in the intestinal tissues of OJ rats. Omega-3 ameliorates OJ-triggered impairment of intestinal barrier function in rats. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Inflammation; Intestinal barrier; Obstructive jaundice; Omega-3 |
| المشرفين على المادة: | 0 (Fatty Acids, Omega-3) 0 (Tight Junction Proteins) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20230728 Date Completed: 20240728 Latest Revision: 20240728 |
| رمز التحديث: | 20240728 |
| DOI: | 10.1007/s12033-023-00829-5 |
| PMID: | 37507597 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1559-0305 |
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| DOI: | 10.1007/s12033-023-00829-5 |