دورية أكاديمية
أعرض في EDS

N 6 -Methyladenosine Directly Regulates CD40L Expression in CD4 + T Lymphocytes.

التفاصيل البيبلوغرافية
العنوان: N 6 -Methyladenosine Directly Regulates CD40L Expression in CD4 + T Lymphocytes.
المؤلفون: van Vroonhoven ECN; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Picavet LW; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Scholman RC; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van den Dungen NAM; Department of Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Mokry M; Department of Experimental Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Evers A; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Calis JJA; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Vastert SJ; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Loosdregt J; Center for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
المصدر: Biology [Biology (Basel)] 2023 Jul 14; Vol. 12 (7). Date of Electronic Publication: 2023 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2012-
مستخلص: T cell activation is a highly regulated process, modulated via the expression of various immune regulatory proteins including cytokines, surface receptors and co-stimulatory proteins. N 6 -methyladenosine (m 6 A) is an RNA modification that can directly regulate RNA expression levels and it is associated with various biological processes. However, the function of m 6 A in T cell activation remains incompletely understood. We identify m 6 A as a novel regulator of the expression of the CD40 ligand (CD40L) in human CD4 + lymphocytes. Manipulation of the m 6 A 'eraser' fat mass and obesity-associated protein (FTO) and m 6 A 'writer' protein methyltransferase-like 3 (METTL3) directly affects the expression of CD40L. The m 6 A 'reader' protein YT521-B homology domain family-2 (YTHDF2) is hypothesized to be able to recognize and bind m 6 A specific sequences on the CD40L mRNA and promotes its degradation. This study demonstrates that CD40L expression in human primary CD4 + T lymphocytes is regulated via m 6 A modifications, elucidating a new regulatory mechanism in CD4 + T cell activation that could possibly be leveraged in the future to modulate T cell responses in patients with immune-related diseases.
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فهرسة مساهمة: Keywords: CD40 ligand; RNA methylation; T cell activation; adaptive immunity; autoimmunity; epitranscriptomics
تواريخ الأحداث: Date Created: 20230729 Latest Revision: 20230731
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10376055
DOI: 10.3390/biology12071004
PMID: 37508433
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-7737
DOI:10.3390/biology12071004