دورية أكاديمية
أعرض في EDS

Development and In Vivo Assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded Polymeric Nanocapsules in Alzheimer's Disease Models.

التفاصيل البيبلوغرافية
العنوان: Development and In Vivo Assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded Polymeric Nanocapsules in Alzheimer's Disease Models.
المؤلفون: Funguetto-Ribeiro AC; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Nakama KA; Pharmaceutical Science Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Pinz MP; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Oliveira RL; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Sacramento MD; Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Pereira FSO; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Pinton S; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Wilhelm EA; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Luchese C; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Alves D; Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Ávila DS; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Haas SE; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.; Pharmaceutical Science Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.
المصدر: Brain sciences [Brain Sci] 2023 Jun 28; Vol. 13 (7). Date of Electronic Publication: 2023 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Alzheimer's disease (AD) is the most common form of dementia in older people, and available treatments are palliative and produce undesirable side effects. The 4-phenyltellanyl-7-chloroquinoline (TQ) is an organochalcogen compound studied due to its pharmacological properties, particularly its antioxidant potential. However, TQ possesses some drawbacks such as low aqueous solubility and high toxicity, thus warranting the search for tools that improve the safety and effectiveness of new compounds. Here, we developed and investigated the biological effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model in transgenic Caenorhabditis elegans expressing human Aβ 1-42 in their body-wall muscles and Swiss mice injected with Aβ 25-35 . The NCTQ displayed good physicochemical properties, including nanometer size and maximum encapsulation capacity. The treatment showed low toxicity, reduced Aβ peptide-induced paralysis, and activated an endoplasmic reticulum chaperone in the C. elegans model. The Aβ injection in mice caused memory impairment, which NCTQ mitigated by improving working, long-term, and aversive memory. Additionally, no changes in biochemical markers were evidenced in mice, demonstrating that there was no hepatotoxicity in the tested doses. Altogether, these findings provide insights into the neuroprotective effects of TQ and indicate that NCTQ is a promising candidate for AD treatment.
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معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 423435/2016-7 National Council for Scientific and Technological Development; 16/2551-0000207-0 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 16/2551-0000240-1 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 19/2551-0001970-0 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
فهرسة مساهمة: Keywords: nanoparticles; neurodegeneration; neuroprotection; organochalcogenium; tellurium
تواريخ الأحداث: Date Created: 20230729 Latest Revision: 20230731
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10377448
DOI: 10.3390/brainsci13070999
PMID: 37508931
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3425
DOI:10.3390/brainsci13070999