دورية أكاديمية
Development and In Vivo Assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded Polymeric Nanocapsules in Alzheimer's Disease Models.
العنوان: | Development and In Vivo Assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded Polymeric Nanocapsules in Alzheimer's Disease Models. |
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المؤلفون: | Funguetto-Ribeiro AC; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Nakama KA; Pharmaceutical Science Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Pinz MP; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Oliveira RL; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Sacramento MD; Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Pereira FSO; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Pinton S; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Wilhelm EA; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Luchese C; Biochemistry and Bioprospecting Graduate Program, Biochemical Pharmacology Research Laboratory (LaFarBio), Neurobiotechnology Research Group (GPN), Chemical, Pharmaceutical and Food Science Center (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Alves D; Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas-UFPel, Pelotas 96010-900, Brazil., Ávila DS; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil., Haas SE; Biochemistry Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil.; Pharmaceutical Science Graduate Program, Federal University of Pampa-UNIPAMPA, Uruguaiana 97501-970, Brazil. |
المصدر: | Brain sciences [Brain Sci] 2023 Jun 28; Vol. 13 (7). Date of Electronic Publication: 2023 Jun 28. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مستخلص: | Alzheimer's disease (AD) is the most common form of dementia in older people, and available treatments are palliative and produce undesirable side effects. The 4-phenyltellanyl-7-chloroquinoline (TQ) is an organochalcogen compound studied due to its pharmacological properties, particularly its antioxidant potential. However, TQ possesses some drawbacks such as low aqueous solubility and high toxicity, thus warranting the search for tools that improve the safety and effectiveness of new compounds. Here, we developed and investigated the biological effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model in transgenic Caenorhabditis elegans expressing human Aβ |
References: | J Biomed Nanotechnol. 2015 Aug;11(8):1482-93. (PMID: 26295148) J Psychiatr Res. 2019 Feb;109:107-117. (PMID: 30521994) Metab Brain Dis. 2015 Jun;30(3):695-702. (PMID: 25296867) Br J Pharmacol Chemother. 1957 Mar;12(1):12-5. (PMID: 13413144) Ann N Y Acad Sci. 2008 Dec;1147:335-47. (PMID: 19076455) J Trace Elem Med Biol. 2018 Mar;46:17-25. (PMID: 29413106) Pharmacol Biochem Behav. 2009 Jan;91(3):430-5. (PMID: 18790705) Colloids Surf B Biointerfaces. 2016 Sep 1;145:748-756. (PMID: 27295491) Oxid Med Cell Longev. 2018 Jul 4;2018:9241308. (PMID: 30116496) Pharmacol Rep. 2022 Feb;74(1):135-147. (PMID: 34739705) Alzheimers Dement. 2012;8(2):105-13. (PMID: 22404852) Chem Rev. 2004 Dec;104(12):6255-85. (PMID: 15584701) Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9368-72. (PMID: 7568134) Eur J Pharmacol. 2006 Jan 13;530(1-2):81-7. (PMID: 16360145) Neuromolecular Med. 2019 Mar;21(1):1-11. (PMID: 30617737) Neural Regen Res. 2021 Apr;16(4):783-789. (PMID: 33063743) Psychopharmacology (Berl). 1988;94(4):491-5. (PMID: 2836875) J Nanosci Nanotechnol. 2016 Feb;16(2):1257-64. (PMID: 27433575) Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21651-21658. (PMID: 31591219) FEBS Lett. 2005 May 23;579(13):2913-8. (PMID: 15890345) PLoS One. 2011;6(5):e20085. (PMID: 21647448) Methods. 2014 Aug 1;68(3):450-7. (PMID: 24780523) Free Radic Biol Med. 2017 Sep;110:133-141. (PMID: 28571752) Behav Brain Res. 2013 Jun 15;247:241-7. (PMID: 23557695) Eur J Pharm Biopharm. 2017 Aug;117:39-48. (PMID: 28363598) Cell Prolif. 2015 Aug;48(4):465-74. (PMID: 26017818) Science. 2006 Sep 15;313(5793):1604-10. (PMID: 16902091) Biomed Pharmacother. 2022 Sep;153:113410. (PMID: 36076536) Toxicol Sci. 2010 May;115(1):194-201. (PMID: 20133376) Toxicol Sci. 2011 Mar;120 Suppl 1:S109-29. (PMID: 21177774) Behav Brain Res. 2012 Apr 21;230(1):100-7. (PMID: 22342489) Appl Biochem Biotechnol. 2014 Jan;172(2):755-66. (PMID: 24122626) Neurotoxicology. 2022 Jan;88:14-24. (PMID: 34718060) Sci Rep. 2018 Jul 2;8(1):9915. (PMID: 29967544) Eur J Pharmacol. 2016 Jun 5;780:122-8. (PMID: 27020552) Nat Rev Neurol. 2017 Sep 29;13(10):612-623. (PMID: 28960209) Mol Neurobiol. 2023 Mar;60(3):1214-1231. (PMID: 36427137) Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:1-9. (PMID: 30033235) Biomed Pharmacother. 2018 Sep;105:1006-1014. (PMID: 30021335) J Neurosci Res. 2013 Jun;91(6):848-53. (PMID: 23553750) Nutr Neurosci. 2022 Nov 7;:1-12. (PMID: 36342065) Molecules. 2020 Aug 15;25(16):. (PMID: 32824172) Front Genet. 2014 Sep 05;5:279. (PMID: 25250042) Exp Gerontol. 2020 Feb;130:110804. (PMID: 31811892) Eur J Pharm Sci. 2018 Jun 15;118:1-12. (PMID: 29550283) Brain Res. 2019 Oct 15;1721:146325. (PMID: 31325424) Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111356. (PMID: 33254976) Free Radic Biol Med. 2012 May 1;52(9):1903-10. (PMID: 22406322) |
معلومات مُعتمدة: | 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 423435/2016-7 National Council for Scientific and Technological Development; 16/2551-0000207-0 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 16/2551-0000240-1 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 19/2551-0001970-0 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul |
فهرسة مساهمة: | Keywords: nanoparticles; neurodegeneration; neuroprotection; organochalcogenium; tellurium |
تواريخ الأحداث: | Date Created: 20230729 Latest Revision: 20230731 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10377448 |
DOI: | 10.3390/brainsci13070999 |
PMID: | 37508931 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2076-3425 |
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DOI: | 10.3390/brainsci13070999 |