دورية أكاديمية
Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series.
العنوان: | Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series. |
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المؤلفون: | Canarutto D; Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Oltolini C; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Barzaghi F; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Calbi V; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Migliavacca M; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Tucci F; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Gallo V; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Consiglieri G; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Ferrua F; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Recupero S; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Cervi MC; Pediatric Infectious Diseases Division, Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo 05508-000, Brazil., Al-Mousa H; Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia., Pituch-Noworolska A; Department of Immunology, University Children's Hospital, 30-663 Krakow, Poland., Tassan Din C; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Scarpellini P; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Silvani P; Department of Anesthesia and Critical Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Fossati C; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Casiraghi M; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Cirillo DM; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Castagna A; Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy.; Clinic of Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Bernardo ME; Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Aiuti A; Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Cicalese MP; Faculty of Medicine and Surgery, Vita-Salute S. Raffaele University, 20132 Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. |
المصدر: | Biomedicines [Biomedicines] 2023 Jun 24; Vol. 11 (7). Date of Electronic Publication: 2023 Jun 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
مستخلص: | Vaccination with Bacillus Calmette-Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of complications due to uncontrolled replication of the mycobacterium. All patients who developed BCG-related disease were treated successfully and remained free from recurrence of disease. We recommend the prompt initiation of enzyme replacement therapy and secondary prophylaxis to reduce the risk of BCG-related complications in ADA-SCID patients. |
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معلومات مُعتمدة: | institutional core grant Telethon Foundation |
فهرسة مساهمة: | Keywords: enzyme replacement therapy; gene therapy; isoniazid; newborn screening; rifampin; tuberculosis |
تواريخ الأحداث: | Date Created: 20230729 Latest Revision: 20230731 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10376767 |
DOI: | 10.3390/biomedicines11071809 |
PMID: | 37509449 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2227-9059 |
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DOI: | 10.3390/biomedicines11071809 |