دورية أكاديمية
أعرض في EDS

Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients.

التفاصيل البيبلوغرافية
العنوان: Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients.
المؤلفون: Fusi G; IRMB, University Montpellier, INSERM, 34295 Montpellier, France., Constantinides M; IRMB, University Montpellier, INSERM, 34295 Montpellier, France., Fissoun C; IRMB, University Montpellier, INSERM, 34295 Montpellier, France., Pichard L; SAFE-iPSC Facility INGESTEM, Montpellier University Hospital, 34298 Montpellier, France., Pers YM; IRMB, University Montpellier, INSERM, 34295 Montpellier, France.; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier University Hospital, 34298 Montpellier, France., Ferreira-Lopez R; IRMB, University Montpellier, INSERM, 34295 Montpellier, France.; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier University Hospital, 34298 Montpellier, France., Pantesco V; IRMB, University Montpellier, INSERM, 34295 Montpellier, France., Poulet C; Laboratory and Service of Rheumatology, GIGA-I3, Université de Liège, 4000 Liege, Belgium., Malaise O; Laboratory and Service of Rheumatology, GIGA-I3, Université de Liège, 4000 Liege, Belgium., De Seny D; Laboratory and Service of Rheumatology, GIGA-I3, Université de Liège, 4000 Liege, Belgium., Lemaitre JM; IRMB, University Montpellier, INSERM, 34295 Montpellier, France.; SAFE-iPSC Facility INGESTEM, Montpellier University Hospital, 34298 Montpellier, France., Jorgensen C; IRMB, University Montpellier, INSERM, 34295 Montpellier, France.; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier University Hospital, 34298 Montpellier, France., Brondello JM; IRMB, University Montpellier, INSERM, 34295 Montpellier, France.
المصدر: Biomedicines [Biomedicines] 2023 Jul 14; Vol. 11 (7). Date of Electronic Publication: 2023 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Senescent cells promote progressive tissue degeneration through the establishment of a combined inflammatory and trophic microenvironment. The cellular senescence state has therefore emerged as a central driving mechanism of numerous age-related diseases, including osteoarthritis (OA), the most common rheumatic disease. Senescence hallmarks are detectable in chondrocytes, synoviocytes and sub-chondral bone cells. This study investigates how the senescence-driven microenvironment could impact the cell fate of resident osteoarticular mesenchymal stromal/stem cells (MSCs) that are hence contributing to OA disease progression. For that purpose, we performed a comparative gene expression analysis of MSCs isolated from healthy donors that were in vitro chronically exposed either to interferon-gamma (IFN-γ) or Transforming Growth Factor beta 1 (TGFβ1), two archetypical factors produced by senescent cells. Both treatments reduced MSC self-renewal capacities by upregulating different senescence-driven cycle-dependent kinase inhibitors. Furthermore, a common set of differentially expressed genes was identified in both treated MSCs that was also found enriched in MSCs isolated from OA patients. These findings highlight an imprinting of OA MSCs by the senescent joint microenvironment that changes their matrisome gene expression. Altogether, this research gives new insights into OA etiology and points to new innovative therapeutic opportunities to treat OA patients.
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معلومات مُعتمدة: ND Inserm; SENOA European League Against Rheumatism; ND University of Montpellier
فهرسة مساهمة: Keywords: MSC; osteoarthritis; senescence
تواريخ الأحداث: Date Created: 20230729 Latest Revision: 20230731
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10377055
DOI: 10.3390/biomedicines11071994
PMID: 37509633
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines11071994