دورية أكاديمية

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder.

التفاصيل البيبلوغرافية
العنوان: Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder.
المؤلفون: Mikhalitskaya EV; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Vyalova NM; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Ermakov EA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Levchuk LA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Simutkin GG; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Bokhan NA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Ivanova SA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.
المصدر: Genes [Genes (Basel)] 2023 Jul 17; Vol. 14 (7). Date of Electronic Publication: 2023 Jul 17.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Bipolar Disorder*/genetics , Schizophrenia*/genetics, Humans ; Polymorphism, Single Nucleotide/genetics ; Interleukin-6/genetics ; Genetic Predisposition to Disease ; Depression/genetics ; Cytokines/genetics
مستخلص: Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and their response to therapy. This narrative review summarizes the current literature over the past decade on the association of polymorphic variants of cytokine genes with risk, severity, and response to treatment for severe mental disorders such as bipolar disorder, depression, and schizophrenia. A search of literature in databases was carried out using keywords related to depressive disorder, bipolar disorder, schizophrenia, inflammation, and cytokines. Gene lists were extracted from publications to identify common genes and pathways for these mental disorders. Associations between polymorphic variants of the IL1B , IL6 , and TNFA genes were the most replicated and relevant in depression. Polymorphic variants of the IL1B , IL6 , IL6R , IL10 , IL17A , and TNFA genes have been associated with schizophrenia. Bipolar disorder has mainly been associated with polymorphic variants of the IL1B gene. Interestingly, the IL6R gene polymorphism (rs2228145) was associated with all three diseases. Some cytokine genes have also been associated with clinical presentation and response to pharmacotherapy. There is also evidence that some specific polymorphic variants may affect the expression of cytokine genes. Thus, the data from this review indicate a link between neuroinflammation and severe mental disorders.
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فهرسة مساهمة: Keywords: SNP; bipolar disorder; cytokines; depressive disorder; genetic association; genetic markers; schizophrenia; single nucleotide polymorphisms
المشرفين على المادة: 0 (Interleukin-6)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20230729 Date Completed: 20230731 Latest Revision: 20230801
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10379485
DOI: 10.3390/genes14071460
PMID: 37510364
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes14071460