دورية أكاديمية
أعرض في EDS

Vaccine adjuvant-elicited CD8 + T cell immunity is co-dependent on T-bet and FOXO1.

التفاصيل البيبلوغرافية
العنوان: Vaccine adjuvant-elicited CD8 + T cell immunity is co-dependent on T-bet and FOXO1.
المؤلفون: Ivanova DL; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Thompson SB; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Klarquist J; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Harbell MG; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Kilgore AM; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Lasda EL; Department of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Hesselberth JR; Department of Biochemistry & Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA., Hunter CA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kedl RM; Department of Immunology and Microbiology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ross.kedl@cuanschutz.edu.
المصدر: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112911. Date of Electronic Publication: 2023 Jul 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Adjuvants, Vaccine* , CD8-Positive T-Lymphocytes*, Animals ; Mice ; Cell Differentiation ; Immunologic Memory ; Listeria monocytogenes ; Mice, Inbred C57BL ; Transcription Factors
مستخلص: T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8 + T cell fates, where T-bet deficiency leads to ablation of only short-lived effector cells, while FOXO1 deficiency results in selective loss of memory. In contrast, following adjuvanted subunit vaccination in mice, both effector- and memory-fated T cells are compromised in the absence of either T-bet or FOXO1. Thus, unlike responses to challenge with Listeria monocytogenes, productive CD8 + T cell responses to adjuvanted vaccination require coordinated regulation of FOXO1 and T-bet transcriptional programs. Single-cell RNA sequencing analysis confirms simultaneous T-bet, FOXO1, and TCF1 transcriptional activity in vaccine-elicited, but not infection-elicited, T cells undergoing clonal expansion. Collectively, our data show that subunit vaccine adjuvants elicit T cell responses dependent on transcription factors associated with effector and memory cell fates.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
References: Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14113-14118. (PMID: 31227606)
Immunity. 2007 Aug;27(2):281-95. (PMID: 17723218)
J Exp Med. 2015 Nov 16;212(12):2041-56. (PMID: 26503446)
Front Immunol. 2011 Feb 11;2:4. (PMID: 22566795)
Immunity. 2012 Mar 23;36(3):374-87. (PMID: 22425248)
Drug Discov Today. 2002 Jul 1;7(13):719-27. (PMID: 12110228)
Cell Rep. 2018 Mar 27;22(13):3454-3467. (PMID: 29590615)
Nat Immunol. 2014 Jul;15(7):646-656. (PMID: 24836425)
J Immunol. 2008 May 1;180(9):5935-45. (PMID: 18424713)
J Immunol. 2020 Feb 1;204(3):510-517. (PMID: 31871021)
J Exp Med. 2011 May 9;208(5):1001-13. (PMID: 21518797)
Annu Rev Immunol. 2007;25:221-42. (PMID: 17291186)
J Immunol. 2021 Jun 1;206(11):2503-2507. (PMID: 33972373)
Nature. 2022 Sep;609(7929):998-1004. (PMID: 36131022)
Blood Adv. 2018 Jul 24;2(14):1685-1690. (PMID: 30021780)
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. (PMID: 25267651)
Immunity. 2013 Aug 22;39(2):286-97. (PMID: 23932570)
Cell Rep. 2021 Aug 24;36(8):109591. (PMID: 34433030)
Nat Commun. 2017 May 03;8:15050. (PMID: 28466857)
Immunol Res. 2013 Mar;55(1-3):135-45. (PMID: 22948808)
Cell. 2007 Jan 26;128(2):309-23. (PMID: 17254969)
J Immunol. 2013 Jul 1;191(1):187-99. (PMID: 23733882)
Cell Rep. 2015 Sep 29;12(12):2099-110. (PMID: 26365183)
Elife. 2020 Feb 05;9:. (PMID: 32022686)
Immunity. 2015 Mar 17;42(3):457-70. (PMID: 25769609)
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648. (PMID: 27702895)
Immunity. 2010 Aug 27;33(2):229-40. (PMID: 20727791)
Nature. 2013 Oct 3;502(7469):100-4. (PMID: 24025770)
Immunity. 2007 Sep;27(3):393-405. (PMID: 17892848)
J Immunol. 2009 Aug 1;183(3):1695-704. (PMID: 19592655)
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82. (PMID: 20457902)
Nature. 2014 Nov 27;515(7528):572-6. (PMID: 25428506)
J Exp Med. 2018 Feb 5;215(2):575-594. (PMID: 29282254)
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8865-E8874. (PMID: 28973925)
Biochem J. 2022 Feb 17;479(4):525-536. (PMID: 35195252)
Immunity. 2011 Apr 22;34(4):492-504. (PMID: 21497118)
J Immunol. 2021 Jan 1;206(1):89-100. (PMID: 33229443)
Sci Immunol. 2018 Sep 7;3(27):. (PMID: 30194241)
J Exp Med. 2013 Jun 3;210(6):1189-200. (PMID: 23712431)
Immunity. 2019 Jan 15;50(1):195-211.e10. (PMID: 30635237)
Nat Rev Immunol. 2012 Nov;12(11):749-61. (PMID: 23080391)
Vaccine. 2013 Jan 2;31(2):297-305. (PMID: 23137843)
J Immunol. 2009 Aug 15;183(4):2337-48. (PMID: 19635915)
Immunity. 2016 Aug 16;45(2):415-27. (PMID: 27533016)
Nat Rev Immunol. 2012 Sep;12(9):649-61. (PMID: 22918467)
Cancer Res. 2007 Sep 1;67(17):7945-7. (PMID: 17804699)
Nat Med. 2013 Apr;19(4):465-72. (PMID: 23455713)
Cell Res. 2020 Apr;30(4):328-342. (PMID: 32203134)
Immunity. 2010 Jan 29;32(1):67-78. (PMID: 20060330)
Immunity. 2010 Jan 29;32(1):79-90. (PMID: 20096607)
Eur J Pharmacol. 2021 Jan 15;891:173758. (PMID: 33249079)
J Immunol. 2005 Jun 1;174(11):6725-31. (PMID: 15905512)
J Immunol. 2014 Dec 1;193(11):5480-7. (PMID: 25355919)
Nature. 2016 Jan 14;529(7585):216-20. (PMID: 26735015)
Curr Opin Immunol. 2017 Jun;46:103-111. (PMID: 28535458)
Immunity. 2020 May 19;52(5):825-841.e8. (PMID: 32396847)
EMBO J. 2015 Aug 4;34(15):2008-24. (PMID: 26136212)
Cell Rep. 2018 Feb 20;22(8):2107-2117. (PMID: 29466737)
Nat Med. 2005 Jul;11(7):748-56. (PMID: 15951824)
Methods. 2003 Nov;31(3):217-24. (PMID: 14511954)
J Exp Med. 2004 Mar 15;199(6):775-84. (PMID: 15007094)
Scand J Immunol. 2004 Jan;59(1):1-15. (PMID: 14723616)
Cell Rep. 2015 Dec 15;13(10):2203-18. (PMID: 26628372)
Sci Immunol. 2016 Dec 23;1(6):. (PMID: 28018990)
Nat Rev Immunol. 2005 Jul;5(7):521-31. (PMID: 15999093)
معلومات مُعتمدة: R21 AI156456 United States AI NIAID NIH HHS; R01 AI126899 United States AI NIAID NIH HHS; R21 AI171061 United States AI NIAID NIH HHS; R01 AI148919 United States AI NIAID NIH HHS; U01 AI160664 United States AI NIAID NIH HHS; T32 AI074491 United States AI NIAID NIH HHS; R01 AI066121 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: CD8; CP: Immunology; FOXO1; T cell; T-bet; adjuvant; transcription factor; vaccine
المشرفين على المادة: 0 (Adjuvants, Vaccine)
0 (Transcription Factors)
0 (Foxo1 protein, mouse)
0 (T-box transcription factor TBX21)
تواريخ الأحداث: Date Created: 20230730 Date Completed: 20230927 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10577800
DOI: 10.1016/j.celrep.2023.112911
PMID: 37516968
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2023.112911