دورية أكاديمية
Host proteins Alpha-2-Macroglobulin and LRP1 associate with Chandipura virus.
| العنوان: | Host proteins Alpha-2-Macroglobulin and LRP1 associate with Chandipura virus. |
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| المؤلفون: | Dey D; Department of Biotechnology, University of Calcutta, Kolkata, India., Dasgupta A; Department of Botany, University of Calcutta, Kolkata, India., Ghosh D; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, India., Bhattacharjee O; Department of Biotechnology, University of Calcutta, Kolkata, India., Ghosh A; Department of Biological Sciences, Bose Institute, Kolkata, India., Honda A; Tokyo University of Agriculture and Technology, Tokyo, Japan., Chattopadhyay D; Department of Biotechnology, University of Calcutta, Kolkata, India. Electronic address: dhrubajyotic@gmail.com. |
| المصدر: | Biochimie [Biochimie] 2024 Mar; Vol. 218, pp. 105-117. Date of Electronic Publication: 2023 Jul 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: Paris. |
| مواضيع طبية MeSH: | Vesiculovirus* , Transcription Factors*, Child ; Humans ; Macroglobulins ; Low Density Lipoprotein Receptor-Related Protein-1 |
| مستخلص: | Chandipura Virus is an emerging tropical pathogen with a high mortality rate among children. No mode of treatment or antivirals exists against CHPV infection, due to little information regarding its host interaction. Studying viral pathogen interaction with its host can not only provide valuable information regarding its propagation strategy, but also on which host proteins interact with the virus. Identifying these proteins and understanding their role in the infection process can provide more stable anti-viral targets. In this study, we focused on identifying host factors that interact with CHPV and may play a critical role in CHPV infection. We are the first to report the successful identification of Alpha-2-Macroglobulin (A2M), a secretory protein of the host that interacts with CHPV. We also established that LRP1 (Low-density lipoprotein receptor-related protein 1) and GRP78 (Glucose regulated protein 78), receptors of A2M, also interact with CHPV. Furthermore, we could also demonstrate that knocking out A2M has a severe effect on viral infection. We conclusively show the interaction of these host proteins with CHPV. Our findings also indicate that these host proteins could play a role in viral entry into the host cell. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.) |
| المشرفين على المادة: | 0 (Transcription Factors) 0 (Macroglobulins) 0 (LRP1 protein, human) 0 (Low Density Lipoprotein Receptor-Related Protein-1) |
| تواريخ الأحداث: | Date Created: 20230730 Date Completed: 20240221 Latest Revision: 20240221 |
| رمز التحديث: | 20240221 |
| DOI: | 10.1016/j.biochi.2023.07.019 |
| PMID: | 37517577 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1638-6183 |
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| DOI: | 10.1016/j.biochi.2023.07.019 |