دورية أكاديمية
Effect of cholecystokinin on small intestinal motility in suncus murinus.
| العنوان: | Effect of cholecystokinin on small intestinal motility in suncus murinus. |
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| المؤلفون: | Yokota N; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan., Takemi S; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan., Sakata I; Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan; Research Area of Evolutionary Molecular Design, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan. Electronic address: isakata@mail.saitama-u.ac.jp. |
| المصدر: | General and comparative endocrinology [Gen Comp Endocrinol] 2023 Oct 01; Vol. 342, pp. 114352. Date of Electronic Publication: 2023 Jul 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6840 (Electronic) Linking ISSN: 00166480 NLM ISO Abbreviation: Gen Comp Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Sincalide*/pharmacology , Gastrointestinal Motility*, Humans ; Animals ; Dogs ; Myoelectric Complex, Migrating/physiology ; Cholecystokinin/pharmacology ; Stomach ; Shrews ; Receptors, Cholecystokinin |
| مستخلص: | In a fasting gastrointestinal tract, a characteristic cyclical rhythmic migrating motor complex (MMC) occur that comprises of three phases: I, II, and III. Among these, phase III contractions propagate from the stomach to the lower intestine in mammals, including humans, dogs, and Suncus murinus (suncus). Apart from the phase III of MMC propagating from the stomach, during the gastric phase II, small intestine-originated strong contractions propagate to the lower small intestine; however, the mechanism of contractions originating in the small intestine has not been clarified. In this study, we aimed to elucidate the role of cholecystokinin (CCK) in small intestinal motility. Administration of sulfated CCK-8 in phase I induced phase II-like contractions in the small intestine, which lasted for approximately 10-20 min and then returned to the baseline, while no change was observed in the stomach. Contractions of small intestine induced by CCK-8 were abolished by lorglumide, a CCK1 receptor antagonist. Gastrin, a ligand for the CCK2 receptor, evoked strong contractions in the stomach, but did not induce contractions in the small intestine. To examine the effect of endogenous CCK on contractions of small intestinal origin, lorglumide was administered during phase II. However, there was no change in the duodenal motility pattern, and strong contractions of small intestinal origin were not abolished by treatment with lorglumide. These results suggest that exogenous CCK stimulates contractions of small intestine via CCK1 receptors, whereas endogenous CCK is not involved in the strong contractions of small intestinal origin. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CCK; Small intestinal motility; Suncus murinus |
| المشرفين على المادة: | M03GIQ7Z6P (Sincalide) 9011-97-6 (Cholecystokinin) 0 (Receptors, Cholecystokinin) |
| تواريخ الأحداث: | Date Created: 20230730 Date Completed: 20230821 Latest Revision: 20230821 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.ygcen.2023.114352 |
| PMID: | 37517599 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-6840 |
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| DOI: | 10.1016/j.ygcen.2023.114352 |