دورية أكاديمية
Renal and hypothalamic inflammation in renovascular hypertension: role of afferent renal nerves.
| العنوان: | Renal and hypothalamic inflammation in renovascular hypertension: role of afferent renal nerves. |
|---|---|
| المؤلفون: | Lauar MR; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States.; Department of Physiology and Pathology, Dentistry School, São Paulo State University-UNESP, Araraquara, São Paulo, Brazil., Evans LC; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States., Van Helden D; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States., Fink GD; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States., Banek CT; Department of Physiology, University of Arizona Health Sciences, Tucson, Arizona, United States., Menani JV; Department of Physiology and Pathology, Dentistry School, São Paulo State University-UNESP, Araraquara, São Paulo, Brazil., Osborn JW; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, United States. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2023 Oct 01; Vol. 325 (4), pp. R411-R422. Date of Electronic Publication: 2023 Jul 31. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Hypertension, Renovascular* , Hypertension* , Nephritis*, Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Kidney ; Sympathetic Nervous System ; Hypothalamus ; Inflammation ; Blood Pressure/physiology |
| مستخلص: | Renal denervation (RDN) is a potential therapy for drug-resistant hypertension. However, whether its effects are mediated by ablation of efferent or afferent renal nerves is not clear. Previous studies have implicated that renal inflammation and the sympathetic nervous system are driven by the activation of afferent and efferent renal nerves. RDN attenuated the renal inflammation and sympathetic activity in some animal models of hypertension. In the 2 kidney,1 clip (2K1C) model of renovascular hypertension, RDN also decreased sympathetic activity; however, mechanisms underlying renal and central inflammation are still unclear. We tested the hypothesis that the mechanisms by which total RDN (TRDN; efferent + afferent) and afferent-specific RDN (ARDN) reduce arterial pressure in 2K1C rats are the same. Male Sprague-Dawley rats were instrumented with telemeters to measure mean arterial pressure (MAP), and after 7 days, a clip was placed on the left renal artery. Rats underwent TRDN, ARDN, or sham surgery of the clipped kidney and MAP was measured for 6 wk. Weekly measurements of water intake (WI), urine output (UO), and urinary copeptin were conducted, and urine was analyzed for cytokines/chemokines. Neurogenic pressor activity (NPA) was assessed at the end of the protocol calculated by the depressor response after intraperitoneal injection of hexamethonium. Rats were euthanized and the hypothalamus and kidneys removed for measurement of cytokine content. MAP, NPA, WI, and urinary copeptin were significantly increased in 2K1C-sham rats, and these responses were abolished by both TRDN and ARDN. 2K1C-sham rats presented with renal and hypothalamic inflammation and these responses were largely mitigated by TRDN and ARDN. We conclude that RDN attenuates 2K1C hypertension primarily by ablation of afferent renal nerves which disrupts bidirectional renal neural-immune pathways. NEW & NOTEWORTHY Hypertension resulting from reduced perfusion of the kidney is dependent on renal sensory nerves, which are linked to inflammation in the kidney and hypothalamus. Afferent renal nerves are required for chronic increases in both water intake and vasopressin release observed following renal artery stenosis. Findings from this study suggest an important role of renal sensory nerves that has previously been underestimated in the pathogenesis of 2K1C hypertension. |
| References: | Exp Physiol. 2015 Apr 20;100(5):496-501. (PMID: 25639235) Exp Physiol. 2007 Jan;92(1):109-17. (PMID: 17012145) Brain Behav Immun. 2007 Aug;21(6):727-35. (PMID: 17604598) Peptides. 2018 Mar;101:82-88. (PMID: 29305157) FASEB J. 2006 Aug;20(10):1748-50. (PMID: 16809436) Auton Neurosci. 2017 May;204:48-56. (PMID: 28126464) J Neurophysiol. 2002 Sep;88(3):1387-92. (PMID: 12205159) Am J Physiol. 1989 Jun;256(6 Pt 2):R1240-4. (PMID: 2735450) Hypertension. 2010 Feb;55(2):500-7. (PMID: 20038749) Neuroendocrinology. 1981 Apr;32(4):248-56. (PMID: 7012657) Trends Immunol. 2018 Mar;39(3):240-255. (PMID: 29338939) Neuropharmacology. 1977 Jul-Aug;16(7-8):463-72. (PMID: 917252) Front Physiol. 2018 May 18;9:578. (PMID: 29867591) Lancet. 2020 May 2;395(10234):1444-1451. (PMID: 32234534) Am J Physiol Renal Physiol. 2011 Mar;300(3):F734-42. (PMID: 21159736) Cytokine. 2019 Jan;113:185-194. (PMID: 30539780) Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1089-97. (PMID: 20147609) Pflugers Arch. 2020 Mar;472(3):325-334. (PMID: 31925527) J Am Coll Cardiol. 2017 Feb 28;69(8):951-964. (PMID: 28231948) Compr Physiol. 2017 Mar 16;7(2):263-320. (PMID: 28333375) Clin Exp Pharmacol Physiol. 2011 Feb;38(2):144-52. (PMID: 20678153) Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1103-11. (PMID: 25637549) Clin Exp Pharmacol Physiol. 2010 Oct;37(10):1016-22. (PMID: 20626757) Brain Res. 1988 Apr 12;446(1):17-25. (PMID: 3370480) Am J Physiol. 1985 Sep;249(3 Pt 2):R368-71. (PMID: 4037121) Temperature (Austin). 2018 Nov 1;5(4):296-307. (PMID: 30574524) Trends Endocrinol Metab. 2008 Mar;19(2):43-9. (PMID: 18291667) J Clin Invest. 1935 Jul;14(4):443-58. (PMID: 16694318) Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R818-28. (PMID: 23535460) Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R883-R891. (PMID: 29513561) Front Physiol. 2020 Dec 15;11:601237. (PMID: 33384613) Circ Res. 1993 Nov;73(5):906-13. (PMID: 8403260) Hypertens Res. 2020 Nov;43(11):1192-1203. (PMID: 32461634) Lancet. 2018 Jun 9;391(10137):2346-2355. (PMID: 29803589) J Exp Med. 1934 Feb 28;59(3):347-79. (PMID: 19870251) Am J Pathol. 2002 Nov;161(5):1679-93. (PMID: 12414515) J Pharmacol Toxicol Methods. 1996 Feb;35(1):45-54. (PMID: 8645881) Cardiovasc Res. 2009 Jun 1;82(3):503-12. (PMID: 19246475) Circ Res. 1983 Nov;53(5):592-602. (PMID: 6194914) Cardiovasc Revasc Med. 2021 Mar;24:77-86. (PMID: 32958438) Congest Heart Fail. 2010 Jul;16 Suppl 1:S37-44. (PMID: 20653710) J Hypertens Suppl. 1992 Dec;10(7):S113-9. (PMID: 1291646) News Physiol Sci. 1998 Aug;13:170-176. (PMID: 11390784) Circulation. 2017 May 30;135(22):2155-2162. (PMID: 28330983) Pharmacol Ther. 2021 Jul;223:107799. (PMID: 33359600) Toxicol Appl Pharmacol. 2014 Sep 1;279(2):141-9. (PMID: 24937322) Nat Rev Neurosci. 2006 May;7(5):335-46. (PMID: 16760914) Hypertension. 2012 Aug;60(2):419-24. (PMID: 22733462) Adv Clin Exp Med. 2014 May-Jun;23(3):319-25. (PMID: 24979502) Auton Neurosci. 2017 May;204:57-64. (PMID: 27527558) Am J Physiol. 1985 Nov;249(5 Pt 2):R634-7. (PMID: 4061683) Life Sci. 2023 Apr 15;319:121538. (PMID: 36868399) J Neurophysiol. 2019 Jul 1;122(1):358-367. (PMID: 31091159) Auton Neurosci. 2014 Jul;183:23-9. (PMID: 24560525) Hypertens Res. 2021 Nov;44(11):1385-1394. (PMID: 34518650) Antioxidants (Basel). 2022 May 20;11(5):. (PMID: 35624870) Front Physiol. 2019 Apr 30;10:491. (PMID: 31114507) Hypertension. 2019 May;73(5):1079-1086. (PMID: 30879356) J Am Coll Cardiol. 2019 Jun 18;73(23):3006-3017. (PMID: 31196459) Am J Physiol Regul Integr Comp Physiol. 2013 Dec;305(11):R1390-400. (PMID: 24089375) eNeuro. 2022 Jan 20;9(1):. (PMID: 34937769) Annu Rev Physiol. 2021 Feb 10;83:429-450. (PMID: 33566672) Am J Physiol. 1987 Apr;252(4 Pt 2):R801-7. (PMID: 2882695) J Neurosci. 2021 Feb 10;41(6):1349-1362. (PMID: 33303682) Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15;308(2):R112-22. (PMID: 25411365) J Exp Med. 2007 Oct 1;204(10):2449-60. (PMID: 17875676) Hipertens Riesgo Vasc. 2022 Jan-Mar;39(1):14-23. (PMID: 34969653) J Neurosci. 2008 Dec 24;28(52):14062-73. (PMID: 19109489) Hypertension. 2016 Dec;68(6):1415-1423. (PMID: 27698066) Curr Hypertens Rep. 2016 Sep;18(9):69. (PMID: 27595156) Am J Physiol Renal Physiol. 2009 Nov;297(5):F1427-34. (PMID: 19692481) Am J Physiol. 1986 Feb;250(2 Pt 2):F189-96. (PMID: 3753828) Hypertension. 1981 Jan-Feb;3(1):34-8. (PMID: 7009426) Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R407-14. (PMID: 23364523) Nat Rev Cardiol. 2022 Jun;19(6):379-394. (PMID: 35301456) Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1136-42. (PMID: 20147611) Physiol Rev. 1991 Jul;71(3):659-82. (PMID: 1647536) Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15;310(2):R197-208. (PMID: 26582638) Compr Physiol. 2011 Apr;1(2):731-67. (PMID: 23737201) Hypertension. 2009 Dec;54(6):1195-201. (PMID: 19822798) Cell Res. 2016 Jan;26(1):83-102. (PMID: 26691752) Am J Physiol. 1986 Jan;250(1 Pt 2):H82-6. (PMID: 3942241) Exp Physiol. 2019 Aug;104(8):1306-1323. (PMID: 31074108) Physiol Rev. 2017 Jul 1;97(3):1127-1164. (PMID: 28566539) Hypertension. 2010 Aug;56(2):297-303. (PMID: 20547972) |
| معلومات مُعتمدة: | R01 HL116476 United States HL NHLBI NIH HHS; R01 HL152166 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: afferent renal nerves; hypothalamus; renal inflammatory cytokines; renovascular hypertension; sympathetic pressor activity |
| تواريخ الأحداث: | Date Created: 20230731 Date Completed: 20230918 Latest Revision: 20231116 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10639016 |
| DOI: | 10.1152/ajpregu.00072.2023 |
| PMID: | 37519252 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
|---|---|
| DOI: | 10.1152/ajpregu.00072.2023 |