دورية أكاديمية
أعرض في EDS

Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.

التفاصيل البيبلوغرافية
العنوان: Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.
المؤلفون: Rechtman E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Navarro E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., de Water E; Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota., Tang CY; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, New York., Curtin P; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Papazaharias DM; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Ambrosi C; ASST Spedali Civili Hospital, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Mascaro L; ASST Spedali Civili Hospital, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Cagna G; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Gasparotti R; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Invernizzi A; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Reichenberg A; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Austin C; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Arora M; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Smith DR; Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California., Lucchini RG; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida., Wright RO; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York., Placidi D; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Horton MK; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
المصدر: Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2022 Apr 19; Vol. 3 (3), pp. 460-469. Date of Electronic Publication: 2022 Apr 19 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of Society of Biological Psychiatry Country of Publication: United States NLM ID: 9918227369306676 Publication Model: eCollection Cited Medium: Internet ISSN: 2667-1743 (Electronic) Linking ISSN: 26671743 NLM ISO Abbreviation: Biol Psychiatry Glob Open Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc. on behalf of Society of Biological Psychiatry, [2021]-
مستخلص: Background: Early-life environmental exposures during critical windows (CWs) of development can impact life course health. Exposure to neuroactive metals such as manganese (Mn) during prenatal and early postnatal CWs may disrupt typical brain development, leading to persistent behavioral changes. Males and females may be differentially vulnerable to Mn, presenting distinctive CWs to Mn exposure.
Methods: We used magnetic resonance imaging to investigate sex-specific associations between early-life Mn uptake and intrinsic functional connectivity in adolescence. A total of 71 participants (15-23 years old; 53% female) from the Public Health Impact of Manganese Exposure study completed a resting-state functional magnetic resonance imaging scan. We estimated dentine Mn concentrations at prenatal, postnatal, and early childhood periods using laser ablation-inductively coupled plasma-mass spectrometry. We performed seed-based correlation analyses to investigate the moderating effect of sex on the associations between Mn and intrinsic functional connectivity adjusting for age and socioeconomic status.
Results: We identified significant sex-specific associations between dentine Mn at all time points and intrinsic functional connectivity in brain regions involved in cognitive and motor function: 1) prenatal: dorsal striatum, occipital/frontal lobes, and middle frontal gyrus; 2) postnatal: right putamen and cerebellum; and 3) early childhood: putamen and occipital, frontal, and temporal lobes. Network associations differed depending on exposure timing, suggesting that different brain networks may present distinctive CWs to Mn.
Conclusions: These findings suggest that the developing brain is vulnerable to Mn exposure, with effects lasting through late adolescence, and that females and males are not equally vulnerable to these effects. Future studies should investigate cognitive and motor outcomes related to these associations.
(© 2022 The Authors.)
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معلومات مُعتمدة: P30 ES023515 United States ES NIEHS NIH HHS; R01 ES019222 United States ES NIEHS NIH HHS; TL1 TR004420 United States TR NCATS NIH HHS; UL1 TR004419 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Adolescence; Critical windows; Functional connectivity; MRI; Manganese; Sex-specific
تواريخ الأحداث: Date Created: 20230731 Latest Revision: 20240326
رمز التحديث: 20240326
مُعرف محوري في PubMed: PMC10382697
DOI: 10.1016/j.bpsgos.2022.03.016
PMID: 37519473
قاعدة البيانات: MEDLINE
الوصف
تدمد:2667-1743
DOI:10.1016/j.bpsgos.2022.03.016