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Route of dexamethasone administration influences parasite burden in Strongyloides hyperinfection model.

التفاصيل البيبلوغرافية
العنوان: Route of dexamethasone administration influences parasite burden in Strongyloides hyperinfection model.
المؤلفون: Corrêa LQ; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., do Couto BP; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., de Carvalho EFG; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., de Sousa JEN; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., da Silva Ribeiro V; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., Gonzaga HT; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil., Costa-Cruz JM; Laboratório de Diagnóstico de Parasitoses, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais Brazil.
المصدر: Journal of parasitic diseases : official organ of the Indian Society for Parasitology [J Parasit Dis] 2023 Sep; Vol. 47 (3), pp. 520-526. Date of Electronic Publication: 2023 May 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer India Country of Publication: India NLM ID: 9713059 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0971-7196 (Print) Linking ISSN: 09717196 NLM ISO Abbreviation: J Parasit Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2009-> : New Dehli : Springer India
Original Publication: Lucknow, India : Indian Society for Parasitology, c1995-
مستخلص: Rodents infected with Strongyloides venezuelensis are experimental models applied to strongyloidiasis research. This study evaluated oral and subcutaneous dexamethasone (DEX) treatments to establish immunosuppression in an experimental model of Strongyloides hyperinfection. Rattus norvegicus Wistar were divided: G I (-): untreated and uninfected animals, G II (+): untreated and infected, G III (o -) orally treated and uninfected, G IV (o +) orally treated and infected, G V (sc -) subcutaneously treated and uninfected, G VI (sc +) subcutaneously treated and infected. For oral administration, DEX was diluted in sterile water (5 µg/ml) and made available to the animals on intervals in experimental days - 5-0, 8-13 and 21-26. For subcutaneous administration, animals received daily injections of DEX disodium phosphate (2 mg/kg). Infection was established by the subcutaneous inoculation of 3000 S. venezuelensis filarioid larvae. Groups were evaluated by egg per gram of feces and parasite females counts and IgG, IgG1 and IgG2a detection. GIV (o +) had egg peaks count on days 13 and 26 and maintained egg elimination until the last experimental day. Parasitic females recovery at day 30 was significantly higher in G IV (o +) when compared to G VI (sc +). Levels of IgG, IgG1 and IgG2a of all groups, except the positive control GII (+), were below the detection threshold. Pharmacological immunosuppression induced by oral administration of DEX produced high parasitic burden, and is a noninvasive method, useful to establish immunosuppression in strongyloidiasis hyperinfection model in rats.
Competing Interests: Conflict of interestThe authors declare no competing interests.
(© Indian Society for Parasitology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
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فهرسة مساهمة: Keywords: Dexamethasone; Experimental infection; Hyperinfection; Immunosuppression; Strongyloides venezuelensis
تواريخ الأحداث: Date Created: 20230731 Latest Revision: 20230928
رمز التحديث: 20230929
مُعرف محوري في PubMed: PMC10382442
DOI: 10.1007/s12639-023-01595-6
PMID: 37520210
قاعدة البيانات: MEDLINE
الوصف
تدمد:0971-7196
DOI:10.1007/s12639-023-01595-6