دورية أكاديمية
Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps.
| العنوان: | Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps. |
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| المؤلفون: | Modestino L; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy., Cristinziano L; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy., Trocchia M; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy., Ventrici A; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy., Capone M; Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', 80131, Naples, Italy., Madonna G; Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', 80131, Naples, Italy., Loffredo S; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131, Naples, Italy., Ferrara AL; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131, Naples, Italy., Romanelli M; Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', 80131, Naples, Italy., Simeone E; Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', 80131, Naples, Italy., Varricchi G; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131, Naples, Italy., Rossi FW; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy., de Paulis A; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy., Marone G; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), 80131, Naples, Italy., Ascierto PA; Melanoma, Cancer Immunotherapy, and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', 80131, Naples, Italy., Galdiero MR; Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131, Naples, Italy. mariarosaria.galdiero@unina.it.; WAO Center of Excellence, University of Naples Federico II, 80131, Naples, Italy. mariarosaria.galdiero@unina.it.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131, Naples, Italy. mariarosaria.galdiero@unina.it. |
| المصدر: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2023 Oct; Vol. 72 (10), pp. 3363-3376. Date of Electronic Publication: 2023 Jul 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York, NY : Springer International, c1982- |
| مواضيع طبية MeSH: | Extracellular Traps* , Melanoma*/pathology, Humans ; Neutrophils/pathology ; Chemotaxis ; Tumor Microenvironment |
| مستخلص: | Polymorphonuclear neutrophils (PMNs) are the main effector cells in the inflammatory response. The significance of PMN infiltration in the tumor microenvironment remains unclear. Metastatic melanoma is the most lethal skin cancer with an increasing incidence over the last few decades. This study aimed to investigate the role of PMNs and their related mediators in human melanoma. Highly purified human PMNs from healthy donors were stimulated in vitro with conditioned media (CM) derived from the melanoma cell lines SKMEL28 and A375 (melanoma CM), and primary melanocytes as controls. PMN biological properties (chemotaxis, survival, activation, cell tracking, morphology and NET release) were evaluated. We found that the A375 cell line produced soluble factors that promoted PMN chemotaxis, survival, activation and modification of morphological changes and kinetic properties. Furthermore, in both melanoma cell lines CM induced chemotaxis, activation and release of neutrophil extracellular traps (NETs) from PMNs. In contrast, the primary melanocyte CM did not modify the biological behavior of PMNs. In addition, serum levels of myeloperoxidase, matrix metalloprotease-9, CXCL8/IL-8, granulocyte and monocyte colony-stimulating factor and NETs were significantly increased in patients with advanced melanoma compared to healthy controls. Melanoma cell lines produce soluble factors able to "educate" PMNs toward an activated functional state. Patients with metastatic melanoma display increased circulating levels of neutrophil-related mediators and NETs. Further investigations are needed to better understand the role of these "tumor-educated neutrophils" in modifying melanoma cell behavior. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | 25123 Fondazione AIRC per la ricerca sul cancro ETS; 2017M8YMR8_005 Ministero dell'Istruzione, dell'Università e della Ricerca |
| فهرسة مساهمة: | Keywords: Melanoma; Neutrophil extracellular traps; Neutrophils; Tumor-associated neutrophil |
| تواريخ الأحداث: | Date Created: 20230731 Date Completed: 20230911 Latest Revision: 20230921 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10491523 |
| DOI: | 10.1007/s00262-023-03493-5 |
| PMID: | 37525065 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00262-023-03493-5 |