دورية أكاديمية
أعرض في EDS

Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.

التفاصيل البيبلوغرافية
العنوان: Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.
المؤلفون: Kijpaisalratana N; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA., Ament Z; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA., Patki A; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Bhave VM; Harvard Medical School, Boston, MA, USA., Jones AC; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Garcia Guarniz AL; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA., Couch CA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA., Long DL; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Irvin MR; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Kimberly WT; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. wtkimberly@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA. wtkimberly@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. wtkimberly@mgh.harvard.edu.
المصدر: Translational stroke research [Transl Stroke Res] 2023 Aug 02. Date of Electronic Publication: 2023 Aug 02.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer
مستخلص: Approximately one-quarter of strokes occur in individuals with prior stroke. Despite the advancement in secondary stroke prevention, the long-term risk of recurrent stroke has remained unchanged. The objective of this study was to identify metabolite risk markers that are associated with recurrent stroke. We performed targeted metabolomic profiling of 162 metabolites by liquid chromatography-tandem mass spectrometry in baseline plasma in a stroke case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, an observational cohort study of 30,239 individuals aged 45 and older enrolled in 2003-2007. Weighted Cox proportional hazard models were used to identify metabolites that had a differential effect on first-time versus recurrent stroke using an interaction term between metabolite and prior stroke at baseline (yes or no). The study included 1391 incident stroke cases identified during 7.1 ± 4.5 years of follow-up and 1050 participants in the random cohort sample. Among 162 metabolites, 13 candidates had a metabolite-by-prior stroke interaction at a p-value <0.05, with one metabolite, acetylglutamine, surpassing the Bonferroni adjusted p-value threshold (p for interaction = 5.78 × 10 -5 ). In an adjusted model that included traditional stroke risk factors, acetylglutamine was associated with recurrent stroke (HR = 2.27 per SD increment, 95% CI = 1.60-3.20, p = 3.52 × 10 -6 ) but not with first-time stroke (HR = 0.96 per SD increment, 95% CI = 0.87-1.06, p = 0.44). Acetylglutamine was associated with recurrent stroke but not first-time stroke, independent of traditional stroke risk factors. Future studies are warranted to elucidate the pathogenesis of acetylglutamine and recurrent stroke risk.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة: P20 GM135007 United States GM NIGMS NIH HHS; R01 NS099209 United States NS NINDS NIH HHS; T32 HL007457 United States HL NHLBI NIH HHS; U01 NS041588 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Acetylglutamine; Metabolomics; Recurrent stroke; Risk factors
تواريخ الأحداث: Date Created: 20230802 Latest Revision: 20240223
رمز التحديث: 20240223
مُعرف محوري في PubMed: PMC10834852
DOI: 10.1007/s12975-023-01181-1
PMID: 37531033
قاعدة البيانات: MEDLINE
الوصف
تدمد:1868-601X
DOI:10.1007/s12975-023-01181-1