دورية أكاديمية
Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy.
| العنوان: | Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. |
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| المؤلفون: | van Kammen DP, van Kammen WB, Mann LS, Seppala T, Linnoila M |
| المصدر: | Archives of general psychiatry [Arch Gen Psychiatry] 1986 Oct; Vol. 43 (10), pp. 978-83. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Assn Country of Publication: United States NLM ID: 0372435 Publication Model: Print Cited Medium: Print ISSN: 0003-990X (Print) Linking ISSN: 0003990X NLM ISO Abbreviation: Arch Gen Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, American Medical Assn. |
| مواضيع طبية MeSH: | Cerebral Cortex/*pathology , Dopamine/*metabolism , Schizophrenia/*cerebrospinal fluid, 3,4-Dihydroxyphenylacetic Acid/cerebrospinal fluid ; Adolescent ; Adult ; Atrophy ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/metabolism ; Dopamine/cerebrospinal fluid ; Female ; Homovanillic Acid/cerebrospinal fluid ; Humans ; Male ; Middle Aged ; Schizophrenia/diagnosis ; Tomography, X-Ray Computed |
| مستخلص: | Cortical atrophy measured with computed tomography was observed in ten of 53 schizophrenic patients. Levels of homovanillic acid, dihydroxyphenyl acetic acid (DOPAC), conjugated DOPAC, and dopamine sulfate (DASO4) were measured in the cerebrospinal fluid of these patients during a drug-free evaluation. Patients with cortical atrophy had lower cerebrospinal fluid levels of homovanillic acid, DOPAC, and conjugated DOPAC but higher DASO4 levels. Combined measures of dopamine utilization were significantly lower in patients with cortical atrophy. We did not find significant clinical or demographic differences between the patients with and without cortical atrophy. Patients without brain atrophy who had dopamine utilization above the mean showed more psychotic symptoms and shorter duration of illness, while those with dopamine below the mean had more negative symptoms. We propose that both state- and trait-dependent variables affect dopamine turnover. |
| المشرفين على المادة: | 102-32-9 (3,4-Dihydroxyphenylacetic Acid) VTD58H1Z2X (Dopamine) X77S6GMS36 (Homovanillic Acid) |
| تواريخ الأحداث: | Date Created: 19861001 Date Completed: 19861021 Latest Revision: 20190717 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1001/archpsyc.1986.01800100072010 |
| PMID: | 3753162 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-990X |
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| DOI: | 10.1001/archpsyc.1986.01800100072010 |