دورية أكاديمية
أعرض في EDS

HIV and urethritis: time required for antiretroviral therapy to suppress HIV in semen.

التفاصيل البيبلوغرافية
العنوان: HIV and urethritis: time required for antiretroviral therapy to suppress HIV in semen.
المؤلفون: Matoga M; University of North Carolina Project Malawi, Lilongwe, Malawi., Chen JS; Institute for Global Health and Infectious Diseases., Massa C; University of North Carolina Project Malawi, Lilongwe, Malawi., Thengolose I; University of North Carolina Project Malawi, Lilongwe, Malawi., Tegha G; University of North Carolina Project Malawi, Lilongwe, Malawi., Ndalama B; University of North Carolina Project Malawi, Lilongwe, Malawi., Bonongwe N; University of North Carolina Project Malawi, Lilongwe, Malawi., Mathiya E; University of North Carolina Project Malawi, Lilongwe, Malawi., Jere E; University of North Carolina Project Malawi, Lilongwe, Malawi., Banda G; University of North Carolina Project Malawi, Lilongwe, Malawi., Khan S; University of North Carolina Project Malawi, Lilongwe, Malawi., Loftis AJ; Institute for Global Health and Infectious Diseases., Kashuba A; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Cottrell ML; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Schauer AP; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Van Horne B; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Tompkins LA; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC., Lancaster KE; The Ohio State University College of Public Health, Columbus, OH, USA., Miller WC; The Ohio State University College of Public Health, Columbus, OH, USA., Eron JJ; Institute for Global Health and Infectious Diseases., Hoffman IF; Institute for Global Health and Infectious Diseases., Cohen MS; Institute for Global Health and Infectious Diseases.
المصدر: AIDS (London, England) [AIDS] 2023 Nov 15; Vol. 37 (14), pp. 2233-2238. Date of Electronic Publication: 2023 Aug 02.
نوع المنشور: Observational Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : London, England : Lippincott Williams & Wilkins
Original Publication: London : Gower Academic Journals, c1987-
مواضيع طبية MeSH: HIV Infections*/drug therapy , Urethritis*/drug therapy , HIV-1* , Anti-HIV Agents*/therapeutic use, Male ; Humans ; Adult ; Semen ; Cohort Studies ; Viral Load
مستخلص: Objectives: To examine the time required to suppress HIV in the genital tract with antiretroviral therapy (ART) in men with urethritis.
Design: An observational cohort study.
Methods: Men with HIV and urethritis not on ART were enrolled at an STI clinic in Malawi and offered to initiate ART. Blood and semen samples were collected pretreatment and at 1, 2, 4, 8, 12 and 24 weeks posturethritis treatment. Median viral loads (VLs) were calculated by ART initiation groups: 'within 1 week', 'between 1 and 4 weeks' and 'no ART before 4 weeks', based on the men's choice about whether or not to initiate ART. The presence of ART at each visit was confirmed by bioanalytical methods.
Findings: Between January 2017 and November 2018, 74 men presented with urethritis and HIV and were confirmed ART naive. The median age was 32 years. Forty-one (55% of men) initiated ART within 1 week; 12 (16%) between 1 and 4 weeks; and 21 (28%) did not initiate ART by week 4. Within the 1 week group, median VL was suppressed within 4 weeks in both semen and blood. Among the 1-4 weeks group, VL was suppressed within 4 weeks in semen and 5 weeks in blood. Among the no ART before 4 weeks group, VL in semen declined within the first 4 weeks but remained unsuppressed through week 24, and there was no significant decline in blood HIV.
Conclusion: Treatment of urethritis and prompt initiation of ART with counseling for safer sex for at least one month is a critical measure to reduce transmission of HIV.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
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معلومات مُعتمدة: T32 AI070114 United States AI NIAID NIH HHS; R01 AI114320 United States AI NIAID NIH HHS; D43 TW010060 United States TW FIC NIH HHS; P30 AI050410 United States AI NIAID NIH HHS; R01 DK108424 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Anti-HIV Agents)
تواريخ الأحداث: Date Created: 20230803 Date Completed: 20231026 Latest Revision: 20231128
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10621634
DOI: 10.1097/QAD.0000000000003679
PMID: 37534689
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5571
DOI:10.1097/QAD.0000000000003679