دورية أكاديمية
Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development.
العنوان: | Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development. |
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المؤلفون: | Bhattacharyya S; Ragon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts 02139., Crain CR; Ragon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts 02139., Goldberg B; Ragon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts 02139., Gaiha GD; Ragon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts 02139.; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02115. |
المصدر: | Current opinion in HIV and AIDS [Curr Opin HIV AIDS] 2023 Sep 01; Vol. 18 (5), pp. 257-263. Date of Electronic Publication: 2023 Jul 18. |
نوع المنشور: | Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101264945 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-6318 (Electronic) Linking ISSN: 1746630X NLM ISO Abbreviation: Curr Opin HIV AIDS Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2006- |
مواضيع طبية MeSH: | HIV Infections* , AIDS Vaccines*, Humans ; CD8-Positive T-Lymphocytes ; Vaccination ; Vaccine Development |
مستخلص: | Purpose of Review: CD8+ T cell responses are a key component of the host immune response to human immunodeficiency virus (HIV) but vary significantly across individuals with distinct clinical outcomes. These differences help inform the qualitative features of HIV-specific CD8+ T cells that we should aim to induce by vaccination. Recent Findings: We review previous and more recent findings on the features of dysfunctional and functional CD8+ T cell responses that develop in individuals with uncontrolled and controlled HIV infection, with particular emphasis on proliferation, cytotoxic effector function, epitope specificity, and responses in lymph nodes. We also discuss the implications of these findings for both prophylactic and therapeutic T cell vaccine development within the context of T cell vaccine trials. Summary: The induction of HIV specific CD8+ T cell responses is an important goal of ongoing vaccine efforts. Emerging data on the key features of CD8+ T cell responses that distinguish individuals who spontaneously control from those with progressive disease continues to provide key guidance. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
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معلومات مُعتمدة: | DP1 DA058476 United States DA NIDA NIH HHS; DP2 AI154421 United States AI NIAID NIH HHS; R01 AI176533 United States AI NIAID NIH HHS; UM1 AI144462 United States AI NIAID NIH HHS |
المشرفين على المادة: | 0 (AIDS Vaccines) |
تواريخ الأحداث: | Date Created: 20230803 Date Completed: 20230804 Latest Revision: 20230917 |
رمز التحديث: | 20230917 |
مُعرف محوري في PubMed: | PMC10503300 |
DOI: | 10.1097/COH.0000000000000812 |
PMID: | 37535040 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1746-6318 |
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DOI: | 10.1097/COH.0000000000000812 |