دورية أكاديمية
Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach.
| العنوان: | Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach. |
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| المؤلفون: | Clark BL; The University of Queensland, 5391 Warrego Hwy, Gatton, QLD 4343, Australia. Electronic address: brianna-clark@outlook.com., Stewart AJ; The University of Queensland, 5391 Warrego Hwy, Gatton, QLD 4343, Australia., Kemp KL; The University of Queensland, 5391 Warrego Hwy, Gatton, QLD 4343, Australia., Bamford NJ; The University of Melbourne, Park Drive, Parkville, VIC 3010, Australia., Bertin FR; The University of Queensland, 5391 Warrego Hwy, Gatton, QLD 4343, Australia. |
| المصدر: | Veterinary journal (London, England : 1997) [Vet J] 2023 Aug-Sep; Vol. 298-299, pp. 106019. Date of Electronic Publication: 2023 Aug 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Balliere Tindall Original Publication: London : Ballière Tindall, c1997- |
| مواضيع طبية MeSH: | Horse Diseases*/diagnosis , Foot Diseases*/diagnosis , Foot Diseases*/veterinary, Horses ; Animals ; Insulin ; Blood Glucose ; Glucose Tolerance Test/veterinary ; Bayes Theorem ; Administration, Intravenous/veterinary |
| مستخلص: | Field tests and their association with laminitis have not been evaluated in large cohorts. The objectives of this study were to evaluate the performance of basal insulin (BI), the oral sugar test (OST) and the insulin tolerance test (ITT) to diagnose ID and investigate their association with laminitis. Insulin dysregulation status was determined in 146 ponies using BI (insulin concentration >20 µIU/mL), an OST (insulin concentration >65 µIU/mL at 60 or 90 min after oral administration of 0.45 mL/kg corn syrup) and an ITT (< 50% reduction in glucose concentration 30 min after intravenous administration of 0.1 IU/kg insulin). Laminitis was identified using modified-Obel scores. A Bayesian approach was used to define the characteristics of the tests and receiver operating characteristic curves were used to assess their association with laminitis. All tests were well tolerated and laminitis was diagnosed in 9% of ponies. Insulin dysregulation was diagnosed in 15% of ponies using BI, 38% using the OST and 54% using the ITT with 11% of ponies positive for all three tests. The sensitivities and specificities of BI, the OST and the ITT to diagnose ID were 0.52 (95% confidence interval [CI], 0.35-0.79) and 0.97 (95% CI, 0.91 - 1.00), 0.84 (95% CI, 0.70 - 0.94) and 0.60 (95% CI, 0.49 - 0.71), and 0.85 (95% CI, 0.68-0.96) and 0.88 (95% CI, 0.75 - 0.97), respectively. Only BI and the OST were associated with laminitis (P = 0.003 and 0.015, respectively). Competing Interests: Declaration of Competing Interest None of the authors has any other financial or personal relationships that could inappropriately influence or bias the content of the paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Equine metabolic syndrome; Hyperinsulinemia; Hyperinsulinemia-associated laminitis; Insulin tolerance test; Oral sugar test |
| المشرفين على المادة: | 0 (Insulin) 0 (Blood Glucose) |
| تواريخ الأحداث: | Date Created: 20230803 Date Completed: 20231102 Latest Revision: 20240501 |
| رمز التحديث: | 20240501 |
| DOI: | 10.1016/j.tvjl.2023.106019 |
| PMID: | 37536451 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2971 |
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| DOI: | 10.1016/j.tvjl.2023.106019 |