دورية أكاديمية
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Respiratory syncytial virus entry mechanism in host cells: A general overview.

التفاصيل البيبلوغرافية
العنوان: Respiratory syncytial virus entry mechanism in host cells: A general overview.
المؤلفون: Cadena-Cruz C; División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia.; Facultad de Ciencias de la Salud, Programa de Medicina, Universidad Libre Seccional Barranquilla, Barranquilla, Colombia., Villarreal Camacho JL; Facultad de Ciencias de la Salud, Programa de Medicina, Universidad Libre Seccional Barranquilla, Barranquilla, Colombia., De Ávila-Arias M; División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia., Hurtado-Gomez L; División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia., Rodriguez A; División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia., San-Juan-Vergara H; División Ciencias de la Salud, Universidad del Norte Barranquilla, Barranquilla, Colombia.
المصدر: Molecular microbiology [Mol Microbiol] 2023 Sep; Vol. 120 (3), pp. 341-350. Date of Electronic Publication: 2023 Aug 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-
مواضيع طبية MeSH: Respiratory Syncytial Virus, Human*/metabolism , Respiratory Syncytial Virus Infections*, Infant, Newborn ; Humans ; Aged ; Antibodies, Neutralizing ; Viral Fusion Proteins/metabolism
مستخلص: Respiratory syncytial virus (RSV) is a virus that causes acute respiratory infections in neonates and older adults. To infect host cells, the attachment glycoprotein (G) interacts with a cell surface receptor. This interaction determines the specific cell types that are susceptible to infection. RSV possesses a type I fusion protein F. Type I fusion proteins are metastable when rearrangement of the prefusion F occurs; the fusion peptide is exposed transforming the protein into postfusion form. The transition between the prefusion form and its postfusion form facilitates the viral envelope and the host cell membrane to fuse, enabling the virus to enter the host cell. Understanding the entry mechanism employed by RSV is crucial for developing effective antiviral therapies. In this review, we will discuss the various types of viral fusion proteins and explore the potential entry mechanisms utilized by RSV. A deeper understanding of these mechanisms will provide valuable insights for the development of novel approaches to treat RSV infections.
(© 2023 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: endocytosis; fusion proteins; mechanism of entry; plasma membrane; respiratory syncytial virus; viral fusion
المشرفين على المادة: 0 (Antibodies, Neutralizing)
0 (Viral Fusion Proteins)
تواريخ الأحداث: Date Created: 20230804 Date Completed: 20230925 Latest Revision: 20230925
رمز التحديث: 20230925
DOI: 10.1111/mmi.15133
PMID: 37537859
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2958
DOI:10.1111/mmi.15133