دورية أكاديمية
Bioactivity of Eriocephalus africanus essential oil against concanavalin A-induced hepatitis via suppressing immune cell infiltration, inhibiting TNF-α/NF-κB and IFN-γ/STAT1 signaling pathways.
| العنوان: | Bioactivity of Eriocephalus africanus essential oil against concanavalin A-induced hepatitis via suppressing immune cell infiltration, inhibiting TNF-α/NF-κB and IFN-γ/STAT1 signaling pathways. |
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| المؤلفون: | Haikal A; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: abdullahhaikal@mans.edu.eg., Galala AA; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: amalgalala@mans.edu.eg., Elshal M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: mahmoudelshal@mans.edu.eg., Amen Y; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: yhiaamen@mans.edu.eg., Gohar AA; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: gohar@mans.edu.eg. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jan 10; Vol. 318 (Pt B), pp. 117000. Date of Electronic Publication: 2023 Aug 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Oils, Volatile*/pharmacology , Oils, Volatile*/therapeutic use , Oils, Volatile*/metabolism , Hepatitis*/metabolism, Animals ; Mice ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Concanavalin A/metabolism ; Concanavalin A/pharmacology ; Signal Transduction ; Liver ; Inflammation/pathology ; Cytokines/metabolism |
| مستخلص: | Ethnopharmacological Relevance: Eriocephalus africanus infusion is used as a diuretic and a diaphoretic and is also used in the treatment of gastrointestinal disorders and gynaecological conditions, inflammation and dermal disorders, asthma, coughs, fevers, and painful ailments. The plant has been used traditionally as a medication to cure inflammation and skin problems. Aim of the Study: Studying E. africanus essential oil (EAEO) as a potential hepatoprotective measure against concanavalin (Con) A-induced hepatitis in mice and investigating its underlying mechanism. Materials and Methods: Hydro-distilled oil of the fresh plant aerial shoots is subjected to GC/MS analysis. Autoimmune hepatitis (AIH) was induced in mice by intravenous injection of Con A (15 mg/kg). EAEO was administered orally before Con A injection to test its hepatoprotective activity. Results: GC/MS analysis revealed the presence of 22 compounds representing 99.43% of the oil components. The monoterpene artemisia ketone (41.02%) and the sesquiterpene juniper camphor (14.17%) are the major components. The in vivo study showed that the oil suppressed Con A-induced neutrophil and CD4+T cell infiltration into the liver, restored hepatic redox balance, inhibited Con A-induced elevation of tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and interferon-gamma (IFN-γ) hepatic levels which were correlated with its ability to suppress nuclear factor kappa B (NF-κB) and Signal Transducer and Activator of Transcription (STAT1) activation in the liver. Conclusion: EAEO showed hepatoprotective potential against Con A-induced hepatitis in mice collectively through selective anti-oxidant, anti-inflammatory, and anti-necrotic effects. Competing Interests: Declaration of competing interest The Authors declare that there is no conflict of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Artemisia ketone; Autoimmune hepatitis; Concanavalin A; Eriocephalus africanus var. africanus; Essential oil |
| المشرفين على المادة: | 0 (NF-kappa B) 0 (Tumor Necrosis Factor-alpha) 11028-71-0 (Concanavalin A) 0 (Oils, Volatile) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20230806 Date Completed: 20230918 Latest Revision: 20230918 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jep.2023.117000 |
| PMID: | 37544345 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2023.117000 |