دورية أكاديمية
Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy.
| العنوان: | Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy. |
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| المؤلفون: | Wu T; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore, 117599, Singapore., Tan JHL; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Sin WX; Critical Analytics for Manufacturing of Personalized Medicine, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore., Luah YH; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore, 117599, Singapore.; Critical Analytics for Manufacturing of Personalized Medicine, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore., Tan SY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Goh M; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Birnbaum ME; Critical Analytics for Manufacturing of Personalized Medicine, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Chen Q; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Cheow LF; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore, 117599, Singapore.; Critical Analytics for Manufacturing of Personalized Medicine, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore. |
| المصدر: | Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Oct; Vol. 10 (28), pp. e2302175. Date of Electronic Publication: 2023 Aug 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim : WILEY-VCH, [2014]- |
| مواضيع طبية MeSH: | CD8-Positive T-Lymphocytes* , Immunotherapy, Adoptive*, Immunotherapy ; CD4-Positive T-Lymphocytes ; Stem Cells |
| مستخلص: | In keeping with the rule of "form follows function", morphological aspects of a cell can reflect its role. Here, it is shown that the cellular granularity of a lymphocyte, represented by its intrinsic side scatter (SSC), is a potent indicator of its cell state and function. The granularity of a lymphocyte increases from naïve to terminal effector state. High-throughput cell-sorting yields a SSC high population that can mediate immediate effector functions, and a highly prolific SSC low population that can give rise to the replenishment of the memory pool. CAR-T cells derived from the younger SSC low population possess desirable attributes for immunotherapy, manifested by increased naïve-like cells and stem cell memory (T (© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | MOE-000063 Ministry of Education Singapore; SMART-CAMP Singapore-MIT Alliance for Research and Technology - Critical Analytics for Manufacturing of Personalized Medicine; I2101E0001 Industry Alignment Fund-Industry Collaboration |
| فهرسة مساهمة: | Keywords: T cells; cell granularity; immunotherapy; lymphocyte; side scatter |
| تواريخ الأحداث: | Date Created: 20230806 Date Completed: 20231009 Latest Revision: 20231018 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10558660 |
| DOI: | 10.1002/advs.202302175 |
| PMID: | 37544893 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2198-3844 |
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| DOI: | 10.1002/advs.202302175 |