دورية أكاديمية
Evaluation of some immune and inflammatory responses in diabetes and HIV co-morbidity.
| العنوان: | Evaluation of some immune and inflammatory responses in diabetes and HIV co-morbidity. |
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| المؤلفون: | Chukwuanukwu RC; Medical Laboratory Science Department, Nnamdi Azikiwe University, Nnewi Campus, Nigeria., Nwosu NB; Medical Laboratory Science Department, Nnamdi Azikiwe University, Nnewi Campus, Nigeria., Ifeanyichukwu MO; Medical Laboratory Science Department, Nnamdi Azikiwe University, Nnewi Campus, Nigeria., Nsonwu-Anyanwu AC; Medical Laboratory Science Department, University of Calabar, Calabar, Nigeria., Manafa PO; Medical Laboratory Science Department, Nnamdi Azikiwe University, Nnewi Campus, Nigeria. |
| المصدر: | African health sciences [Afr Health Sci] 2023 Mar; Vol. 23 (1), pp. 120-128. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Medicine, Makerere University Country of Publication: Uganda NLM ID: 101149451 Publication Model: Print Cited Medium: Internet ISSN: 1729-0503 (Electronic) Linking ISSN: 16806905 NLM ISO Abbreviation: Afr Health Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : Faculty of Medicine, Makerere University, [2001- |
| مواضيع طبية MeSH: | HIV Infections*/complications , HIV Infections*/epidemiology , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/epidemiology, Humans ; Interleukin-6 ; Immunoglobulin G ; Immunoglobulin M ; Morbidity |
| مستخلص: | Background: Co-existence of diabetes in the HIV infected reportedly further complicates the attendant impairment of immunity and increases susceptibility to opportunistic infections. Objective: This study aimed to evaluate some immune and inflammatory parameters in HIV and type 2 diabetes (T2D) co-morbidity: Immunoglobulin M and G (IgM and IgG), Interleukin-6, CD4+ T-cells and C-reactive protein. Method: The study involved 200 subjects grouped according to their HIV and diabetes status: Group 1 'Diabetic HIV seropositive' (n=40), Group 2 'Non diabetic HIV seropositive'(n=60), Group 3 'Diabetic HIV seronegative'(n=50), and Group 4 'Control non diabetic HIV seronegative'(n=50). Blood samples were collected for testing. Results: CRP levels were significantly elevated in diabetes and HIV co-morbidity compared to other groups. IL-6 levels were significantly higher in diabetics with or without HIV infection. In addition, IL-6 was significantly elevated in individuals with poor glycemic control (HbA1c > 9.0%) compared to those with good glycemic control. IgG and IgM levels in diabetic HIV seropositive subjects were highest compared with other groups. Conclusion: The increased IL-6, CRP, IgG, IgM and decreased CD4+ T cell counts observed in co-morbidity suggest that HIV and T2D co-morbidity exacerbate the immune and inflammatory impairment observed in either disease entity. Competing Interests: The authors report no conflict of interest. (© 2023 Chukwuanukwu RC et al.) |
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| فهرسة مساهمة: | Keywords: Diabetes; HIV; co-morbidity; glycemic control; immune responses; inflammation |
| المشرفين على المادة: | 0 (Interleukin-6) 0 (Immunoglobulin G) 0 (Immunoglobulin M) |
| تواريخ الأحداث: | Date Created: 20230807 Date Completed: 20230808 Latest Revision: 20230808 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10398510 |
| DOI: | 10.4314/ahs.v23i1.14 |
| PMID: | 37545969 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1729-0503 |
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| DOI: | 10.4314/ahs.v23i1.14 |