التفاصيل البيبلوغرافية
| العنوان: |
Ultra-high density imaging arrays for diffuse optical tomography of human brain improve resolution, signal-to-noise, and information decoding. |
| المؤلفون: |
Markow ZE, Trobaugh JW, Richter EJ, Tripathy K, Rafferty SM, Svoboda AM, Schroeder ML, Burns-Yocum TM, Bergonzi KM, Chevillet MA, Mugler EM, Eggebrecht AT, Culver JP |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 25. Date of Electronic Publication: 2023 Jul 25. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Functional magnetic resonance imaging (fMRI) has dramatically advanced non-invasive human brain mapping and decoding. Functional near-infrared spectroscopy (fNIRS) and high-density diffuse optical tomography (HD-DOT) non-invasively measure blood oxygen fluctuations related to brain activity, like fMRI, at the brain surface, using more-lightweight equipment that circumvents ergonomic and logistical limitations of fMRI. HD-DOT grids have smaller inter-optode spacing (∼13 mm) than sparse fNIRS (∼30 mm) and therefore provide higher image quality, with spatial resolution ∼1/2 that of fMRI. Herein, simulations indicated reducing inter-optode spacing to 6.5 mm would further improve image quality and noise-resolution tradeoff, with diminishing returns below 6.5 mm. We then constructed an ultra-high-density DOT system (6.5-mm spacing) with 140 dB dynamic range that imaged stimulus-evoked activations with 30-50% higher spatial resolution and repeatable multi-focal activity with excellent agreement with participant-matched fMRI. Further, this system decoded visual stimulus position with 19-35% lower error than previous HD-DOT, throughout occipital cortex. |
| معلومات مُعتمدة: |
R01 EB009233 United States EB NIBIB NIH HHS; R01 MH122751 United States MH NIMH NIH HHS; R01 NS090874 United States NS NINDS NIH HHS |
| تواريخ الأحداث: |
Date Created: 20230807 Latest Revision: 20240225 |
| رمز التحديث: |
20240225 |
| مُعرف محوري في PubMed: |
PMC10401969 |
| DOI: |
10.1101/2023.07.21.549920 |
| PMID: |
37547013 |
| قاعدة البيانات: |
MEDLINE |
