دورية أكاديمية
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GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein.

التفاصيل البيبلوغرافية
العنوان: GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein.
المؤلفون: Gusakova MS; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Ivanov MV; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Kashtanova DA; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Taraskina AN; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Erema VV; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Mikova VM; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Loshkarev RI; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Ignatyeva OA; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Akinshina AI; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Mitrofanov SI; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Snigir EA; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Yudin VS; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Makarov VV; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Keskinov AA; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia., Yudin SM; Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2023 Jul 20; Vol. 10, pp. 1178939. Date of Electronic Publication: 2023 Jul 20 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is heavily reliant on its natural ability to "hack" the host's genetic and biological pathways. The genetic susceptibility of the host is a key factor underlying the severity of the disease. Polygenic risk scores are essential for risk assessment, risk stratification, and the prevention of adverse outcomes. In this study, we aimed to assess and analyze the genetic predisposition to severe COVID-19 in a large representative sample of the Russian population as well as to build a reliable but simple polygenic risk score model with a lower margin of error. Another important goal was to learn more about the pathogenesis of severe COVID-19. We examined the tertiary structure of the FYCO1 protein, the only gene with mutations in its coding region and discovered changes in the coiled-coil domain. Our findings suggest that FYCO1 may accelerate viral intracellular replication and excessive exocytosis and may contribute to an increased risk of severe COVID-19. We found significant associations between COVID-19 and LZTFL1 , FYCO1 , XCR1 , CCR9 , TMLHE-AS1 , and SCYL2 at 3p21.31. Our findings further demonstrate the polymorphic nature of the severe COVID-19 phenotype.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Gusakova, Ivanov, Kashtanova, Taraskina, Erema, Mikova, Loshkarev, Ignatyeva, Akinshina, Mitrofanov, Snigir, Yudin, Makarov, Keskinov and Yudin.)
References: N Engl J Med. 2020 Oct 15;383(16):1522-1534. (PMID: 32558485)
Cancer Res. 1993 Dec 1;53(23):5775-9. (PMID: 8242635)
Eur J Hum Genet. 2002 Jan;10(1):52-61. (PMID: 11896456)
Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20803-20813. (PMID: 32764148)
Front Genet. 2021 Feb 11;12:632385. (PMID: 33643391)
J Immunol. 2002 Mar 15;168(6):2811-9. (PMID: 11884450)
J Immunol. 2015 Mar 1;194(5):2079-88. (PMID: 25637027)
Cell Rep Med. 2021 Aug 17;2(8):100370. (PMID: 34467247)
J Biol Chem. 2009 Sep 25;284(39):26716-24. (PMID: 19643732)
Cell. 2020 Dec 10;183(6):1520-1535.e14. (PMID: 33157038)
Int Immunol. 2015 Sep;27(9):435-45. (PMID: 25925170)
Nat Rev Immunol. 2018 Jul;18(7):418-419. (PMID: 29752467)
Cell Discov. 2021 Aug 31;7(1):76. (PMID: 34465742)
J Cell Biol. 2010 Jan 25;188(2):253-69. (PMID: 20100911)
Genes Chromosomes Cancer. 1994 Dec;11(4):237-45. (PMID: 7533527)
Cell Death Dis. 2021 Sep 25;12(10):877. (PMID: 34564708)
Cell. 2020 Oct 1;183(1):158-168.e14. (PMID: 32979941)
Cell. 2014 Dec 18;159(7):1665-80. (PMID: 25497547)
Immunity. 2009 Nov 20;31(5):823-33. (PMID: 19913446)
J Med Virol. 2021 May;93(5):2735-2739. (PMID: 33506952)
Mediators Inflamm. 2016;2016:3635809. (PMID: 27795621)
Cancer Commun (Lond). 2021 Apr;41(4):349-353. (PMID: 33636047)
Nucleic Acids Res. 2019 Jul 2;47(W1):W158-W165. (PMID: 31165883)
Cancer Res. 1992 Feb 15;52(4):873-7. (PMID: 1346586)
BMC Res Notes. 2016 Mar 11;9:159. (PMID: 26969411)
Oncogene. 2016 May 19;35(20):2655-63. (PMID: 26364604)
Eur J Hum Genet. 2021 Jun;29(6):1019-1026. (PMID: 33649539)
Mol Cell. 2020 Apr 16;78(2):224-235.e5. (PMID: 32109364)
J Virol. 2019 May 15;93(11):. (PMID: 30867316)
Genomics. 2001 Apr 1;73(1):10-9. (PMID: 11352561)
Nature. 2021 Mar;591(7848):92-98. (PMID: 33307546)
J Immunol. 2016 Feb 1;196(3):1081-90. (PMID: 26700766)
Front Immunol. 2019 Jan 04;9:2899. (PMID: 30662436)
J Immunol. 2009 Mar 15;182(6):3335-41. (PMID: 19265109)
Cell. 2020 Aug 6;182(3):685-712.e19. (PMID: 32645325)
Annu Rev Immunol. 2005;23:975-1028. (PMID: 15771591)
J Immunol. 2013 Aug 15;191(4):1567-77. (PMID: 23851683)
J Clin Invest. 2021 Dec 1;131(23):. (PMID: 34597274)
Nat Rev Microbiol. 2018 Jun;16(6):341-354. (PMID: 29556036)
Mol Genet Metab. 2020 Jul;130(3):170-171. (PMID: 32386848)
Cancer Res. 1991 Sep 1;51(17):4707-11. (PMID: 1678685)
Cancer Res. 2000 Apr 1;60(7):1949-60. (PMID: 10766185)
J Autoimmun. 2021 Feb;117:102595. (PMID: 33453462)
Genet Epidemiol. 2018 Jun;42(4):366-377. (PMID: 29532500)
Signal Transduct Target Ther. 2021 Feb 22;6(1):85. (PMID: 33619245)
bioRxiv. 2021 May 11;:. (PMID: 34013269)
J Intern Med. 2021 Apr;289(4):523-531. (PMID: 32976665)
PLoS One. 2023 Mar 16;18(3):e0282689. (PMID: 36928239)
Nat Methods. 2018 Aug;15(8):591-594. (PMID: 30013048)
Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):326-333. (PMID: 32744243)
JAMA. 2020 Feb 18;323(7):627-635. (PMID: 32068817)
J Biol Chem. 2002 Jul 19;277(29):26379-88. (PMID: 12006563)
Future Oncol. 2005 Feb;1(1):79-92. (PMID: 16555978)
Bioinformatics. 2010 Sep 15;26(18):2336-7. (PMID: 20634204)
J Med Virol. 2021 Apr;93(4):1843-1846. (PMID: 33314219)
Genet Epidemiol. 2020 Oct;44(7):676-686. (PMID: 32691445)
Sci Rep. 2019 Oct 24;9(1):15275. (PMID: 31649293)
Biochimie. 2020 Dec;179:229-236. (PMID: 33115667)
Nature. 2022 Aug;608(7921):E1-E10. (PMID: 35922517)
Nat Protoc. 2020 Sep;15(9):2759-2772. (PMID: 32709988)
Nature. 1999 Mar 4;398(6722):77-80. (PMID: 10078533)
Autophagy. 2022 Jul;18(7):1728-1731. (PMID: 34709967)
Mol Biol Cell. 2006 Oct;17(10):4513-25. (PMID: 16914521)
Int J Cancer. 1994 May 15;57(4):473-9. (PMID: 8181852)
Blood. 2007 Aug 1;110(3):962-71. (PMID: 17395780)
Clin Proteomics. 2020 Jul 02;17:26. (PMID: 32636717)
Nat Rev Drug Discov. 2021 Oct;20(10):730. (PMID: 34504321)
فهرسة مساهمة: Keywords: COVID-19; FYCO1; genome-wide association study; polygenic risk score; protein folding
تواريخ الأحداث: Date Created: 20230807 Latest Revision: 20231102
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10399629
DOI: 10.3389/fmed.2023.1178939
PMID: 37547597
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2023.1178939