دورية أكاديمية
Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells.
| العنوان: | Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. |
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| المؤلفون: | Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, Ninfa EG, Frey AZ, Gash DJ, Chow EP, et. al. |
| المصدر: | Cell [Cell] 1986 Jun 06; Vol. 45 (5), pp. 685-98. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Print ISSN: 0092-8674 (Print) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, Ma : Cell Press Original Publication: Cambridge, MIT Press. |
| مواضيع طبية MeSH: | Glycoproteins* , Growth Inhibitors*, Testicular Hormones/*genetics, Amino Acid Sequence ; Animals ; Anti-Mullerian Hormone ; Base Sequence ; Cattle ; Chlorocebus aethiops ; Cloning, Molecular ; Cricetinae ; Cricetulus ; Gene Expression Regulation ; Humans ; Male ; Species Specificity ; Testis ; Transfection |
| مستخلص: | We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino acids containing a 24 amino acid leader peptide. The human gene has five exons that code for a protein of 560 amino acids. A comparison of the bovine and human MIS proteins reveals a highly conserved C-terminal domain that shows marked homology with human transforming growth factor-beta and the beta chain of porcine inhibin. Animal cells transfected with the human gene secrete biologically active MIS, which causes regression of the rat Müllerian duct in vitro. |
| معلومات مُعتمدة: | 1 R43 CA 42340-01 United States CA NCI NIH HHS; CA-17393 United States CA NCI NIH HHS |
| سلسلة جزيئية: | GENBANK K03474; M13151 |
| المشرفين على المادة: | 0 (Glycoproteins) 0 (Growth Inhibitors) 0 (Testicular Hormones) 80497-65-0 (Anti-Mullerian Hormone) |
| تواريخ الأحداث: | Date Created: 19860606 Date Completed: 19860714 Latest Revision: 20220408 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1016/0092-8674(86)90783-x |
| PMID: | 3754790 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0092-8674 |
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| DOI: | 10.1016/0092-8674(86)90783-x |