دورية أكاديمية
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
العنوان: | Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. |
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المؤلفون: | Mehrotra T; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Konar D; Division of Diagnostic Laboratory, Jan Swasthya Sahyog, Ganiyari, Bilaspur 495112, India., Pragasam AK; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Kumar S; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Jana P; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Babele P; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Paul D; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Purohit A; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Tanwar S; Multidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Bakshi S; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Das S; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Verma J; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Talukdar D; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Narendrakumar L; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Kothidar A; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Karmakar SP; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Chaudhuri S; Multidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Pal S; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India., Jain K; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India., Srikanth CV; Laboratory of Gut Infection and Inflammation Biology, Regional Centre for Biotechnology, Faridabad 121001, India., Sankar MJ; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India., Atmakuri K; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India., Agarwal R; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India., Gaind R; Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India., Ballal M; Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India., Kammili N; Department of Microbiology, Pathogen Biology Division, Gandhi Medical College and Hospital, Secunderabad 500003, India., Bhadra RK; Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700 032, India., Ramamurthy T; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.; Division of Bacteriology, Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases, Kolkata 700010, India., Nair GB; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.; Pathogen Biology Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India., Das B; Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India. |
المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug 15; Vol. 120 (33), pp. e2305465120. Date of Electronic Publication: 2023 Aug 07. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
مواضيع طبية MeSH: | Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Escherichia coli*/genetics, beta-Lactamases/genetics ; beta-Lactamases/pharmacology ; Proteomics ; Drug Resistance, Bacterial ; Drug Resistance, Multiple, Bacterial/genetics ; Klebsiella pneumoniae ; Microbial Sensitivity Tests |
مستخلص: | Microbes evolve rapidly by modifying their genomes through mutations or through the horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. We conducted a multicentric study in India and collected different clinical samples for decoding the genome sequences of bacterial pathogens associated with sepsis, urinary tract infections, and respiratory infections to understand the functional potency associated with AMR and its dynamics. Genomic analysis identified several acquired AMR genes (ARGs) that have a pathogen-specific signature. We observed that bla |
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فهرسة مساهمة: | Keywords: Gram-negative pathogens; antimicrobial resistance; antimicrobials; genomics; proteomics |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) EC 3.5.2.6 (beta-Lactamases) |
تواريخ الأحداث: | Date Created: 20230807 Date Completed: 20230809 Latest Revision: 20230821 |
رمز التحديث: | 20230822 |
مُعرف محوري في PubMed: | PMC10434301 |
DOI: | 10.1073/pnas.2305465120 |
PMID: | 37549252 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1091-6490 |
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DOI: | 10.1073/pnas.2305465120 |