دورية أكاديمية
Cerebrospinal fluid lipidomic fingerprint of obstructive sleep apnoea in Alzheimer's disease.
| العنوان: | Cerebrospinal fluid lipidomic fingerprint of obstructive sleep apnoea in Alzheimer's disease. |
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| المؤلفون: | Dakterzada F; Unitat Trastorns Cognitius, Cognition and Behaviour Study Group, Santa Maria University Hospital, IRBLleida, Rovira Roure No. 44, Lleida, 25198, Spain., Benítez ID; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.; Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain., Targa A; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.; Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain., Carnes A; Unitat Trastorns Cognitius, Cognition and Behaviour Study Group, Santa Maria University Hospital, IRBLleida, Rovira Roure No. 44, Lleida, 25198, Spain., Pujol M; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Jové M; Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Spain., Mínguez O; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Vaca R; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Sánchez-de-la-Torre M; Department of Nursing and Physiotherapy, Group of Precision Medicine in Chronic Diseases, University Hospital Arnau de Vilanova and Santa María, IRBLleida, Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain., Barbé F; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.; Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain., Pamplona R; Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Cognition and Behaviour Study Group, Santa Maria University Hospital, IRBLleida, Rovira Roure No. 44, Lleida, 25198, Spain. gerard_437302@hotmail.com. |
| المصدر: | Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Aug 07; Vol. 15 (1), pp. 134. Date of Electronic Publication: 2023 Aug 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central Ltd. |
| مواضيع طبية MeSH: | Alzheimer Disease*/cerebrospinal fluid , Sleep Apnea, Obstructive*/diagnosis , Sleep Apnea, Obstructive*/complications, Humans ; Lipidomics ; Tandem Mass Spectrometry ; Lipids ; Surveys and Questionnaires |
| مستخلص: | Background: Obstructive sleep apnoea (OSA) has a high prevalence in patients with Alzheimer's disease (AD). Both conditions have been shown to be associated with lipid dysregulation. However, the relationship between OSA severity and alterations in lipid metabolism in the brains of patients with AD has yet to be fully elucidated. In this context, we examined the cerebrospinal fluid (CSF) lipidome of patients with suspected OSA to identify potential diagnostic biomarkers and to provide insights into the pathophysiological mechanisms underlying the effect of OSA on AD. Methods: The study included 91 consecutive AD patients who underwent overnight polysomnography (PSG) to diagnose severe OSA (apnoea-hypopnea index ≥ 30/h). The next morning, CSF samples were collected and analysed by liquid chromatography coupled to mass spectrometry in an LC-ESI-QTOF-MS/MS platform. Results: The CSF levels of 11 lipid species were significantly different between AD patients with (N = 38) and without (N = 58) severe OSA. Five lipids (including oxidized triglyceride OxTG(57:2) and four unknown lipids) were significantly correlated with specific PSG measures of OSA severity related to sleep fragmentation and hypoxemia. Our analyses revealed a 4-lipid signature (including oxidized ceramide OxCer(40:6) and three unknown lipids) that provided an accuracy of 0.80 (95% CI: 0.71-0.89) in the detection of severe OSA. These lipids increased the discriminative power of the STOP-Bang questionnaire in terms of the area under the curve (AUC) from 0.61 (0.50-0.74) to 0.85 (0.71-0.93). Conclusions: Our results reveal a CSF lipidomic fingerprint that allows the identification of AD patients with severe OSA. Our findings suggest that an increase in central nervous system lipoxidation may be the principal mechanism underlying the association between OSA and AD. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Alzheimer’s disease; Biomarker; Cerebrospinal fluid; Diagnosis; Lipidomics; Obstructive sleep apnoea; STOP-Bang questionnaire |
| المشرفين على المادة: | 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20230807 Date Completed: 20230809 Latest Revision: 20231121 |
| رمز التحديث: | 20231121 |
| مُعرف محوري في PubMed: | PMC10408111 |
| DOI: | 10.1186/s13195-023-01278-7 |
| PMID: | 37550750 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1758-9193 |
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| DOI: | 10.1186/s13195-023-01278-7 |