دورية أكاديمية
Prevalence of Polycystic Ovarian Syndrome in Girls with a History of Idiopathic Central Precocious Puberty.
| العنوان: | Prevalence of Polycystic Ovarian Syndrome in Girls with a History of Idiopathic Central Precocious Puberty. |
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| المؤلفون: | Arcari AJ; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Freire AV; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Ballerini MG; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Escobar ME; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Díaz Marsiglia YM; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Bergadá I; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Ropelato MG; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Gryngarten MG; División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE) CONICET, FEI, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. |
| المصدر: | Hormone research in paediatrics [Horm Res Paediatr] 2024; Vol. 97 (2), pp. 134-139. Date of Electronic Publication: 2023 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 101525157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1663-2826 (Electronic) Linking ISSN: 16632818 NLM ISO Abbreviation: Horm Res Paediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel : Karger |
| مواضيع طبية MeSH: | Polycystic Ovary Syndrome*/complications , Polycystic Ovary Syndrome*/epidemiology , Puberty, Precocious*/drug therapy , Hyperandrogenism*/complications , Hyperandrogenism*/epidemiology, Adolescent ; Female ; Humans ; Child, Preschool ; Prevalence ; Menarche |
| مستخلص: | Introduction: The prevalence of polycystic ovarian syndrome (PCOS) in adolescent girls is between 1 and 4.3%. It remains controversial whether women with a history of idiopathic central precocious puberty (ICPP) are at increased risk for PCOS. Our objective was to assess the prevalence of PCOS in adolescents with a history of ICPP compared with healthy adolescents and the prevalence of PCOS among ICPP girls who have received or not gonadotropin-releasing hormone analogue (GnRHa) treatment. Methods: We assessed post-menarcheal girls with a history of ICPP. Girls were evaluated at gynecological age ≥2.5 years. Data collected were age at menarche, menstrual cycle characteristics, BMI, clinical hyperandrogenism (HA), total and free testosterone levels. PCOS diagnosis was defined by criteria for adolescents. Subjects were also analyzed regarding whether or not they had received GnRHa treatment. Results: Ninety-four subjects were assessed, and 63 had been treated with GnRHa. Menstrual disorders were found in 29%, clinical HA in 36%, and biochemical HA in 23%. Twelve percent met the diagnostic criteria for PCOS. There was no difference in BMI or in the incidence of menstrual dysfunction or hyperandrogenemia between treated and untreated patients. A higher proportion of clinical HA was found in untreated patients when compared to treated girls. The relative risk (RR) of developing PCOS in ICPP girls was 2.5 compared to a population of healthy adolescents. This RR was not higher in patients who received treatment with GnRHa than in those who did not. Conclusion: Adolescent girls with a history of ICPP have an increased risk of PCOS. This risk seems not to be related to GnRHa treatment. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Adolescent; Central precocious puberty; Gonadotropin-releasing hormone analogue; Polycystic ovarian syndrome |
| تواريخ الأحداث: | Date Created: 20230808 Date Completed: 20240410 Latest Revision: 20240410 |
| رمز التحديث: | 20240410 |
| DOI: | 10.1159/000531264 |
| PMID: | 37552972 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1663-2826 |
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| DOI: | 10.1159/000531264 |