دورية أكاديمية
أعرض في EDS

ABO, Lewis blood group systems and secretory status with H.pylori infection in yemeni dyspeptic patients: a cross- sectional study.

التفاصيل البيبلوغرافية
العنوان: ABO, Lewis blood group systems and secretory status with H.pylori infection in yemeni dyspeptic patients: a cross- sectional study.
المؤلفون: Almorish MA; Department of Hematology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. m.almorish@su.edu.ye., Al-Absi B; Department of Hematology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen., Elkhalifa AME; Public Heath Department, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia.; Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, 1158, Sudan., Elamin E; Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, 1158, Sudan., Elderdery AY; Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Sakaka, Saudi Arabia., Alhamidi AH; Clinical Laboratory Sciences Department, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
المصدر: BMC infectious diseases [BMC Infect Dis] 2023 Aug 08; Vol. 23 (1), pp. 520. Date of Electronic Publication: 2023 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Dyspepsia*/epidemiology , Helicobacter Infections* , Helicobacter pylori*, Male ; Female ; Humans ; ABO Blood-Group System/genetics ; Cross-Sectional Studies ; Lewis Blood Group Antigens/genetics ; Phenotype
مستخلص: Background: The ABO and Lewis blood group antigens are potential factors in susceptibility to H. pylori infection. This research aimed to examine the prevalence of Helicobater pylori (H.pylori) infection and its association with ABO, Lewis blood group systems, and secretory status in Yemeni symptomatic patients.
Methods: In a cross-sectional study, 103 patients referred for endoscopy due to dyspepsia were included. H pylori infection was assessed using stool antigen and serum antibody rapid tests. ABO and Lewis blood group systems were examined using hemagglutination assay. Saliva samples were investigated for identification of the secretory phenotype using hemagglutination inhibition test.
Results: The prevalence of H. pylori infection was (80.6%), with a higher rate of infection in females than males. The ABO blood groups were found to be significantly different between males and females (p = 0.047). The O blood group was prevalent among H. pylori patients, especially secretors. There was a significant association between ABO blood groups and H. pylori infection (p = 0.001). The Le (a + b+) phenotype was the most common, followed by Le (a + b-), Le (a-b+), and Le (a-b-). Lewis blood group systems and secretory status of symptomatic patients were not associated with H. pylori infection. The results showed that serum Ab test for H. pylori achieved poor sensitivity (68%), specificity of 55%; positive predictive value (PPV) 86%, negative predictive value (NPV) 29% and accuracy 65.1%.
Conclusion: The prevalence of H. pylori infection was high in Yemeni patients. This infection was linked to the O and Le (a + b+) secretor phenotype. The H. pylori stool Ag test is the most reliable noninvasive diagnostic method for detecting H. pylori infection.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
التعليقات: Erratum in: BMC Infect Dis. 2024 Jan 15;24(1):85. (PMID: 38225609)
References: Atif Abdulwahab A. Oyouni. Biological and genetic basis of various human genetic disorders and the application of biological and genetic markers. J. King Saud Univ. Sci. 2022:;34(4): 101961. (PMID: 10.1016/j.jksus.2022.101961)
Abegaz SB. Human ABO blood groups and their Associations with different Diseases. BioMed Res Int. 2021;2021:6629060. (PMID: 33564677785085210.1155/2021/6629060)
Brandão de Mattos CC, Mattos LCd. Histo-blood group carbohydrates as facilitators for infection by Helicobacter pylori. Infect Genet Evol. 2017;53:167–74. (PMID: 10.1016/j.meegid.2017.05.025)
Ewald DR, Sumner SCJ. Blood type biochemistry and human disease. Wiley Interdiscip Rev: Syst Biol Med. 2016;8(6):517–35. (PMID: 27599872)
Denomme GA. The structure and function of the molecules that carry human red blood cell and platelet antigens. Transfus Med Rev. 2004;18(3):203–31. (PMID: 1524817010.1016/j.tmrv.2004.03.006)
Marshall, B. J., and Warren, J. R. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. 1983; Lancet 1:1273. (PMID: 6134060)
Chakrani Z, Robinson K, Taye B. Association between ABO blood groups and Helicobacter pylori infection: a meta-analysis. Sci rep. 2018;8(1):1–11. (PMID: 10.1038/s41598-018-36006-x)
Sheikh AF, Yadyad MJ, Goodarzi H, Hashemi SJ, Aslani S, Assarzadegan M-A, et al. CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders. Microb pathog. 2018;122:144–50. (PMID: 2990830710.1016/j.micpath.2018.06.023)
Elamin EAI, Suliman MA, Azoz ME, Ali EW, Olerile LD, Jiao Y, et al. Effect of helicobacter pylori infection on haematological parameters in kosti teaching hospital, sudan. Iran Red Crescent Med J. 2018;20(2).
Smith S, Fowora M, Pellicano R. Infections with Helicobacter pylori and challenges encountered in Africa. World J Gastroenterol. 2019;25(25):3183–95. (PMID: 31333310662672710.3748/wjg.v25.i25.3183)
Kienesberger S, Perez-Perez GI, Olivares AZ, Bardhan P, Sarker SA, Hasan KZ, et al. When is Helicobacter pylori acquired in populations in developing countries? A birth-cohort study in bangladeshi children. Gut microb. 2018;9(3):252–63. (PMID: 10.1080/19490976.2017.1421887)
Gunaid AA, Hassan NA, Murray-Lyon I. Prevalence and risk factors for Helicobacter pylori infection among yemeni dyspeptic patients. Saudi med j. 2003;24(5):512–17. (PMID: 12847628)
Mukbel, M., Ahmed, A. Endoscopic and histological evaluation of chronic Gastritis in Yemen. Suez Canal Univ Med J. 2012; 15(1), 40–48. (PMID: 10.21608/scumj.2012.54675)
Benktander J, Ångström J, Breimer ME, Teneberg S. Redefinition of the carbohydrate binding specificity of Helicobacter pylori BabA adhesin. J Biol Chem;2012;287(38):31712–24. (PMID: 22822069344250610.1074/jbc.M112.387654)
Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am j epid. 2010;172(11):1280–5. (PMID: 10.1093/aje/kwq299)
Bastos, J., Peleteiro, B., Pinto, H., Marinho, A., Guimarães, J. T., Ramos, E., La Vecchia, C., Barros, H., & Lunet, N. Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of portuguese adolescents (EpiTeen). Digestive and liver disease: official journal of the italian society of Gastroenterology and the Italian Association for the study of the liver, 2013; 45(4), 290–95.
Kusters JG, Van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin microb rev. 2006;19(3):449–90. (PMID: 10.1128/CMR.00054-05)
Boren T, Falk P, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Sci. 1993;262(5141):1892–5. (PMID: 10.1126/science.8018146)
Saberi S, Schmidt A, Eybpoosh S, et al.: Helicobacter pylori strains from duodenal ulcer patients exhibit mixed babA/B genotypes with low levels of BabA adhesin and lewis b binding. Dig Dis Sci; 2016; 61:2868–2877. (PMID: 2731869810.1007/s10620-016-4217-z)
Mahdavi J, Sonden B, Hurtig M, et al.: Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Sci. 2002;297:573–578. (PMID: 10.1126/science.1069076)
Moonens K, Gideonsson P, Subedi S, et al.: Structural insights into polymorphic ABO glycan binding by Helicobacter pylori. Cell Host Microbe. 2016;19:55–66. (PMID: 26764597479315110.1016/j.chom.2015.12.004)
Hage N, Howard T, Phillips C, et al.: Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA. Sci Adv. 2015; 1:e1500315. (PMID: 26601230464381110.1126/sciadv.1500315)
Linden S, Nordman H, Hedenbro J, et al.: Strain- and blood groupdependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms. Gastroent. 2002; 123:1923–1930. (PMID: 10.1053/gast.2002.37076)
Posselt G, Backert S, Wessler S: The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal. 2013; 11:77. (PMID: 24099599385149010.1186/1478-811X-11-77)
Aspholm M, Olfat FO, Norden J, et al.: SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. PLoS Pathog. 2006; 2: e110. (PMID: 17121461162610310.1371/journal.ppat.0020110)
Doohan D, Rezkitha YAA, Waskito LA, Yamaoka Y, Miftahussurur M. Helicobacter pylori BabA-SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development. Toxins (Basel). 2021; 13;13(7):485.
Leal YA, Cedillo-Rivera R, Simón JA, Velázquez JR, Flores LL, Torres. Utility of stool sample-based tests for the diagnosis of Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011; 52(6):718–728. (PMID: 2147875710.1097/MPG.0b013e3182077d33)
Kouitcheu Mabeku LB, Noundjeu Ngamga ML, Leundji H. Helicobacter pylori infection, a risk factor for type 2 diabetes mellitus: a hospital-based cross-sectional study among dyspeptic patients in Douala-Cameroon. Sci rep.2020;10(1):12141. (PMID: 32699242737610610.1038/s41598-020-69208-3)
Bercher ME. American Association of Blood Banks Edition. Technical Manual. 15th ed. Bethesda, Maryland: AABB; 2005. Investigation of a positive DAT; pp. 773–4.
Alsulaimany FAS, Awan ZA, Almohamady AM, Koumu MI, Yaghmoor BE, Elhady SS, Elfaky MA. Prevalence of Helicobacter pylori infection and diagnostic methods in the Middle East and North Africa Region. Medicina (Kaunas). 2020;9;56(4):169. (PMID: 10.3390/medicina56040169)
Almashhadany DA, Mayas SM, Mohammed HI, Hassan AA, Khan IUH. Population- and Gender-Based Investigation for Prevalence of Helicobacter pylori in Dhamar, Yemen. Can J Gastroenterol Hepatol. 2023; 25;2023:3800810.
Adeniyi BA, Otegbayo JA, Lawal TO, Oluwasola AO, Odaibo GN, Okolo C, Ola S, Idowu P, Akere A, Kehinde A. Prevalence of Helicobacter pylori infection among dyspepsia patients in Ibadan, South West Nigeria. African Journal of Microbiology Research. 2012; 6(14):3399-402.24.
Aitila P, Mutyaba M, Okeny S, Ndawula Kasule M, Kasule R, Ssedyabane F, et al. Prevalence and risk factors of Helicobacter pylori infection among children aged 1 to 15 years at Holy Innocents Children’s hospital, Mbarara, South Western Uganda. J trop med. 2019;2019:9303072. (PMID: 30984271643152310.1155/2019/9303072)
Ibrahim AMS, Ferro A, Lunet N, Peleteiro B. Sex-differences in the prevalence of Helicobacter pylori infection in pediatric and adult populations: systematic review and meta-analysis of 244 studies. Dig Liver Dis. 2017;49(7):742–9. (PMID: 2849550310.1016/j.dld.2017.03.019)
Khoder G, Muhammad JS, Mahmoud I, Soliman SS, Burucoa C. Prevalence of Helicobacter pylori and its associated factors among healthy asymptomatic residents in the United Arab Emirates. Patho. 2019;8:44–58.
KooffrehAda M, Okonkwo U, Ugbong E, Essien A, Chukwudike E, Edogiawerie D, et al. Prevalence of Helicobacter Pylori infection among dyspepsia patients in Calabar. Global J Pure Appl Sci. 2019;25:145–51.
Ansari, S., R. Gautam, H. P. Nepal, S. N. Subedi, S. Shrestha, F. Mandal, B. Rimal and M. R. Chhetri. Helicobacter pylori colonization in Nepal; assessment of prevalence and potential risk factors in a hospital based patient cohort. BMC Res. Notes. 2016; 9: 59. (PMID: 26833400473616510.1186/s13104-016-1867-z)
Hussein, N.R.; Robinson, K.; Atherton, J.C. A study of age-specific Helicobacter pylori seropositivity rates in Iraq. Helicobacter;2008, 13, 306–307.
Shokrzadeh L, Baghaei K, Yamaoka Y, Shiota S, Mirsattari D, Porhoseingholi A, et al. Prevalence of helicobacter pylori infection in dyspeptic patients in Iran. Gastroenterol Insights. 2012;4:247. (PMID: 10.4081/gi.2012.e8)
Dilnessa T, Amentie M. Prevalence of Helicobacter pylori and risk factors among dyspepsia and non-dyspepsia adults at Assosa general hospital, West Ethiopia: a comparative study. Ethiop J Health Dev. 2017;31(1):4–12.
Shiferaw G, Abera D. Magnitude of Helicobacter pylori and associated risk factors among symptomatic patients attending at Jasmin internal medicine and pediatrics specialized private clinic in Addis Ababa city, Ethiopia. BMC Infect Dis. 2019 6;19(1):118. (PMID: 10.1186/s12879-019-3753-5)
H. Park, J. J. Park, Y. M. Park et al., “The association between helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking,” Helicobacter. 2018; 23(3): e12477. (PMID: 2960057310.1111/hel.12477)
Zhao XX, Liu MH, Wang RL, Tian T. Effect of Gender and Age on the Correlation between Helicobacter pylori and Colorectal Adenomatous Polyps in a Chinese Urban Population: A Single Center Study. Gastroenterol Res Pract. 2020; 10;2020:8596038.
Alhashimi, R. A. H., Alsaad, R. K. A.,Alhilfi, H. S. Q. and Althaalibi, S. M. J. Helicobacter Pylori infection, epidemiology, endoscopic findings and Associated Socio-Demographic factors in Uninvestigated Dyspepsia in the people of Misan, Iraq. J. Gastrointest. Disord. Liver Func. 2017; 3(2):109–113.
Jaka, H., Mushi, M. F., Mirambo, M. M., Wilson, L., Seni, J., Mtebe, M. and Mshana, S.E. Sero-prevalence and associated factors of Helicobacter pylori infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania. Afri. Health Sci. 2016; 16(3): 684–689. (PMID: 10.4314/ahs.v16i3.7)
Cheng, H.; Hu, F.; Zhang, L.; Yang, G.; Ma, J.; Hu, J.; Wang, W.; Gao, W.; Dong, X. Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China. Helicobacter. 2009; 14, 128–133. (PMID: 1929834010.1111/j.1523-5378.2009.00668.x)
Obaid JMAS, Ayoon ANN, Almurisy ONM, Alshuaibi SMS, Alkhawlani NN. Evaluation of antibody immunochromatography testing for diagnosis of current Helicobacter pylori infection. Pract Lab Med. 2021; 24;26:e00245. (PMID: 10.1016/j.plabm.2021.e00245)
Habib, H.S.; Hegazi, M.A.; Murad, H.A.; Amir, E.M.; Halawa, T.F.; El-Deek, B.S. Unique features and risk factors of Helicobacter pylori infection at the main children’s intermediate school in Rabigh, Saudi Arabia. Indian J. Gastroenterol. 2014;33, 375–382. (PMID: 2477789510.1007/s12664-014-0463-1)
Hanafi, M.I.; Mohamed, A.M. Helicobacter pylori infection: Seroprevalence and predictors among healthy individuals in Al Madinah, Saudi Arabia. J. Egypt. Public Health Assoc. 2013; 88, 40–45. (PMID: 2352853110.1097/01.EPX.0000427043.99834.a4)
A.T.B. Abadi, Diagnosis of Helicobacter pylori using invasive and noninvasive approaches, J.Pathog. 2018; 9064952.
C. Hooton, J. Keohane, J. Clair, M. Azam, S. O’Mahony, O. Crosbie, B. Lucey, Comparison of three stool antigen assays with the 13 C-urea breath test for primary diagnosis of Helicobacter pylori infection and monitoring treatment outcome, Eur. J. Gastroenterol. Hepatol. 2006; 595–599.
S. Kato, K. Ozawa, M. Okuda, T. Fujisawa, S. Kagimoto, M. Konno, S. Maisawa, K. Iinuma, Accuracy of the stool antigen test for the diagnosis of childhood Helicobacter pylori infection: a multicenter japanese study, Am. J. Gastroenterol. 2003; 98:296–300. (PMID: 12591044)
S. Kato, K. Ozawa, M. Okuda, Y. Nakayama, N. Yoshimura, M. Konno, et al., Multicenter comparison of rapid lateral flow stool antigen immunoassay and stool antigen enzyme immunoassay for the diagnosis of Helicobacter pylori infection in children, Helicobacter 9 (2004) 669–673. (PMID: 1561008210.1111/j.1083-4389.2004.00279.x)
Majeed PD and Khoshnaw KJ. Seroprevalence of Helicobacter Pylori infection among patients with gastroduodenal disorders in Erbil City. Diyala J Med. 2020; 18: 91–101. (PMID: 10.26505/DJM.18014880818)
Teshome Y, Mekonen W, Birhanu Y, et al. The association between ABO blood group distribution and peptic ulcer disease: a cross-sectional study from Ethiopia. J Blood Med. 2019; 10: 193. (PMID: 31308778661360010.2147/JBM.S209416)
Borén T, Falk P, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993;262(5141):1892–1895. (PMID: 801814610.1126/science.8018146)
Weiss FU, Schurmann C, Guenther A, et al. Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. Gut. 2015;64(4):646–656. (PMID: 2502839810.1136/gutjnl-2014-306930)
Henry S, Oriol R, Samuelsson B. Lewis histo-blood group system and associated secretory phenotypes. Vox Sang. 1995;69:166–82. (PMID: 8578728)
Rampelotti JC, Bueno EC, Valcarenghi D and Geraldo A. Determination of the frequency of Lea Antigens, Leb and Anti-Le antibodies in individuals infected or not by Helicobacter Pylori. J Bacteriol Mycol. 2018; 5(4): 1073.
Oriol R, Abo Hh. Lewis and secretion: serology, genetics and tissue distribution. In: Cartron JP, Rouger P, editors. Blood cell biochemistry: molecular basis of human blood group antigens. New York: Plenum; 1995. p. 37–73. (PMID: 10.1007/978-1-4757-9537-0_2)
Yang, Y.J., Lu, C.L., and Sheu, B.S. Differential H. Pylori-induced MAPK responses regulate Lewis antigen expression and colonization density on gastric epithelial cells between children and adults. Front. Immunol. 2022;13, 849512. (PMID: 35350782895779810.3389/fimmu.2022.849512)
Aryana K, Keramati MR, Zakavi SR, Sadeghian MH, Akbari H. Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients. Nig med J.2013;54(3):196–9. (PMID: 10.4103/0300-1652.114583)
Keramati MR, Sadeghian MH, Ayatollahi H, Badiee Z, Shakibayi H, Moghimi-Roudi A. Role of the Lewis and ABO Blood Group Antigens in Helicobacter pylori infection. Malays J Med Sci. 2012;19(3):17–21. (PMID: 236105453629660)
Fumagalli M, Cagliani R, Pozzoli U, Riva S, Comi GP, Menozzi G, et al. Widespread balancing selection and pathogen-driven selection at blood group antigen genes. Genome Res. 2009;19:199–212. (PMID: 18997004265221410.1101/gr.082768.108)
فهرسة مساهمة: Keywords: ABO; H.pylori; Le; Lewis; Secretor
المشرفين على المادة: 0 (ABO Blood-Group System)
0 (Lewis Blood Group Antigens)
تواريخ الأحداث: Date Created: 20230808 Date Completed: 20230810 Latest Revision: 20240115
رمز التحديث: 20240116
مُعرف محوري في PubMed: PMC10408178
DOI: 10.1186/s12879-023-08496-2
PMID: 37553651
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-023-08496-2