دورية أكاديمية
Avian riboflavin deficiency causes reliably reproducible peripheral nerve demyelination and, with vitamin supplementation, rapid remyelination.
| العنوان: | Avian riboflavin deficiency causes reliably reproducible peripheral nerve demyelination and, with vitamin supplementation, rapid remyelination. |
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| المؤلفون: | Cai Z; Discipline of Anatomy and Pathology, Adelaide Medical School, Adelaide, SA, Australia., Finnie J; Discipline of Anatomy and Pathology, Adelaide Medical School, Adelaide, SA, Australia.; Division of Research and Innovation, University of Adelaide, Adelaide, SA, Australia., Manavis J; Discipline of Anatomy and Pathology, Adelaide Medical School, Adelaide, SA, Australia., Blumbergs P; Discipline of Anatomy and Pathology, Adelaide Medical School, Adelaide, SA, Australia. |
| المصدر: | Human & experimental toxicology [Hum Exp Toxicol] 2023 Jan-Dec; Vol. 42, pp. 9603271231188970. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9004560 Publication Model: Print Cited Medium: Internet ISSN: 1477-0903 (Electronic) Linking ISSN: 09603271 NLM ISO Abbreviation: Hum Exp Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press, c1990- |
| مواضيع طبية MeSH: | Riboflavin Deficiency*/complications , Riboflavin Deficiency*/pathology , Riboflavin Deficiency*/veterinary , Demyelinating Diseases*/chemically induced , Demyelinating Diseases*/pathology , Remyelination* , Peripheral Nervous System Diseases*/etiology , Peripheral Nervous System Diseases*/pathology , Peripheral Nervous System Diseases*/veterinary, Animals ; Rats ; Chickens ; Peripheral Nerves/pathology ; Dietary Supplements ; Vitamins |
| مستخلص: | Riboflavin deficiency produces severe peripheral neve demyelination in young, rapidly growing chickens. While this naturally-occurring vitamin B2 deficiency can cause a debilitating peripheral neuropathy, and mortality, in poultry flocks, it can also be a useful experimental animal model to study the pathogenesis of reliably reproducible peripheral nerve demyelination. Moreover, restitution of normal riboflavin levels in deficient birds results in brisk remyelination. It is the only acquired, primary, demyelinating tomaculous neuropathy described to date in animals. The only other substance that causes peripheral nerve demyelination similar to avian riboflavin deficiency is tellurium and the pathologic features of the peripheral neuropathy produced by this developmental neurotoxin in weanling rats are also described. |
| فهرسة مساهمة: | Keywords: Riboflavin deficiency; avian peripheral nerves; demyelination |
| المشرفين على المادة: | 0 (Vitamins) |
| تواريخ الأحداث: | Date Created: 20230808 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/09603271231188970 |
| PMID: | 37553751 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0903 |
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| DOI: | 10.1177/09603271231188970 |