دورية أكاديمية
Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles.
| العنوان: | Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles. |
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| المؤلفون: | Peleli M; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.; Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Lyngso KS; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Poulsen FR; Department of Neurosurgery, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark and BRIDGE (Brain Research-Interdisciplinary Guided Excellence), Odense, Denmark.; OPEN - Odense Patient Data Explorative Network, Odense, Denmark., Hansen PBL; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Papapetropoulos A; Laboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.; Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Stubbe J; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. |
| المصدر: | Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2023 Sep; Vol. 239 (1), pp. e14021. Date of Electronic Publication: 2023 Aug 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-1716 (Electronic) Linking ISSN: 17481708 NLM ISO Abbreviation: Acta Physiol (Oxf) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Pub., c2006-4 |
| مواضيع طبية MeSH: | Arterioles*/drug effects , Arterioles*/metabolism , Cystathionine gamma-Lyase*/antagonists & inhibitors , Cystathionine gamma-Lyase*/metabolism , Enzyme Inhibitors*/pharmacology , Vasoconstriction*, Animals ; Humans ; Mice ; Hydrogen Sulfide/metabolism ; Mice, Inbred C57BL |
| مستخلص: | Aim: In extracerebral vascular beds cystathionine-gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H Methods: Intracerebral arterioles were isolated from wild type C57BL/6J mouse (9-12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set-up. Reverse transcription polymerase chain reaction was used for detecting CSE expression. Results: CSE is expressed in human and mouse intracerebral arterioles. CSE inhibition with L-propargylglycine (PAG) significantly dampened the K + -induced vasoconstriction in intracerebral arterioles of both species (% of maximum contraction: in human control: 45.4 ± 2.7 versus PAG: 27 ± 5.2 and in mouse control: 50 ± 1.5 versus PAG: 33 ± 5.2) but did not affect the secondary dilatation. This effect of PAG was significantly reversed by the H Conclusion: CSE contributes to the K + -induced vasoconstriction via a mechanism involving H (© 2023 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.) |
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| فهرسة مساهمة: | Keywords: contractility; cystathionine-gamma lyase; endothelial NO synthase; hydrogen sulfide; intracerebral arterioles; soluble guanylate cyclase |
| المشرفين على المادة: | EC 4.4.1.1 (Cystathionine gamma-Lyase) 0 (Enzyme Inhibitors) YY9FVM7NSN (Hydrogen Sulfide) |
| تواريخ الأحداث: | Date Created: 20230809 Date Completed: 20230901 Latest Revision: 20231012 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/apha.14021 |
| PMID: | 37555636 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1748-1716 |
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| DOI: | 10.1111/apha.14021 |