دورية أكاديمية
Triamcinolone Acetonide Produced by Bacillus velezensis YEBBR6 Exerts Antagonistic Activity Against Fusarium oxysporum f. sp. Cubense: A Computational Analysis.
| العنوان: | Triamcinolone Acetonide Produced by Bacillus velezensis YEBBR6 Exerts Antagonistic Activity Against Fusarium oxysporum f. sp. Cubense: A Computational Analysis. |
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| المؤلفون: | Nayana RUK; Department of Plant Biotechnology, Tamil Nadu Agricultural University, Coimbatore, 641003, India., Nakkeeran S; Department of Plant Biotechnology, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore, 641003, India. nakkeeranayya@tnau.ac.in., Saranya N; Department of Plant Molecular Biology and Bioinformatics, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore, 641003, India., Saravanan R; Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, 641003, India., Mahendra K; Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, 641003, India., Ashraf S; Department of Plant Biotechnology, Tamil Nadu Agricultural University, Coimbatore, 641003, India., Perveen K; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box-22452, Riyadh, 11495, Saudi Arabia., Alshaikh NA; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box-22452, Riyadh, 11495, Saudi Arabia., Sayyed RZ; Department of Microbiology, PSGVP Mandal's, S. I. Patil Arts, G.B. Patel Science and STKV Sangh Commerce College, Shahada, 425409, India. sayyedrz@gmail.com.; Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Putra Nilai, 71800, Nilai, Negeri Sembilan, Malaysia. sayyedrz@gmail.com., Show PL; Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou, 325035, China. pauloke.show@ku.ac.ae.; Department of Chemical Engineering, Khalifa University, Shakhbout Bin Sultan St - Zone 1, Abu Dhabi, United Arab Emirates. pauloke.show@ku.ac.ae.; Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor Darul Ehsan, Malaysia. pauloke.show@ku.ac.ae. |
| المصدر: | Molecular biotechnology [Mol Biotechnol] 2023 Aug 09. Date of Electronic Publication: 2023 Aug 09. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Cham] : Springer Original Publication: Totowa, NJ : Humana Press, c1994- |
| مستخلص: | Fusarium oxysporum f. sp. cubense is one of the most severe and threatening pathogens of bananas, causing "Panama wilt" worldwide. Confrontation assay of Foc antagonistic bacterial endophyte, Bacillus velezensis YEBBR6, with the Foc and GC-MS profiling of excised agar from the zone of inhibition, led to the unveiling of secondary metabolites produced by the endophyte. To refine the probable antifungal compounds among the numerous biomolecules formed during their di-trophic interaction with the pathogen, fungal protein targets were modeled, and docking studies (AutoDock Vina module of the PyRx 0.8 server) were done with all the compounds. Triamcinolone acetonide exhibited the most excellent affinity for the protein targets among the compounds studied. It had a maximum binding affinity of 11.2 kcal/mol for XRN2 (5' → 3'). Further, the protein-ligand complex formation kinetics was done through Molecular Dynamic Simulation studies. Graphs for the RMSD, RMSF, Rg, potential energy, and SASA were generated, and the values during the simulation period suggested the stability of the biomolecule as a complex with the protein. This indicated Triamcinolone acetonide's potential ability to act as a functional disrupter of the target protein and likely an antifungal molecule. Further, the biomolecule was tested for its activity against Foc by screening in the wet lab through the poisoned plate technique, and it was found to be fully inhibitory to the growth of the pathogen at 1000 ppm. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Antifungal; Endophytes; Molecular dynamic simulation; Triamcinolone acetonide |
| تواريخ الأحداث: | Date Created: 20230809 Latest Revision: 20230809 |
| رمز التحديث: | 20230809 |
| DOI: | 10.1007/s12033-023-00797-w |
| PMID: | 37556108 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s12033-023-00797-w |