دورية أكاديمية
أعرض في EDS

Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.

التفاصيل البيبلوغرافية
العنوان: Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.
المؤلفون: Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Janova H; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Cain MD; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Alippe Y; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Muraro S; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Sariol A; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Elam-Noll M; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Klein RS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mdiamond@wustl.edu.
المصدر: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112946. Date of Electronic Publication: 2023 Aug 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Encephalomyelitis, Venezuelan Equine*/pathology , Receptors, LDL*/physiology, Animals ; Mice ; Brain/pathology ; Central Nervous System ; Encephalitis Virus, Venezuelan Equine/physiology
مستخلص: Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported entry receptor for VEEV. Here, using wild-type and Ldlrad3-deficient mice, we define a critical role for LDLRAD3 in controlling steps in VEEV infection, pathogenesis, and neurotropism. Our analysis shows that LDLRAD3 is required for efficient VEEV infection and pathogenesis prior to and after central nervous system invasion. Ldlrad3-deficient mice survive intranasal and intracranial VEEV inoculation and show reduced infection of neurons in different brain regions. As LDLRAD3 is a determinant of pathogenesis and an entry receptor required for VEEV infection of neurons of the brain, receptor-targeted therapies may hold promise as countermeasures.
Competing Interests: Declaration of interests M.S.D. is a consultant for Inbios, Vir Biotechnology, Ocugen, Topspin Therapeutics, Moderna, and Immunome. The Diamond laboratory has received unrelated funding support in sponsored research agreements from Moderna, Vir Biotechnology, Generate Biomedicines, and Emergent BioSolutions.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: J Virol. 2000 Jan;74(2):914-22. (PMID: 10623754)
PLoS Negl Trop Dis. 2009 Jun 30;3(6):e472. (PMID: 19564908)
Expert Rev Anti Infect Ther. 2022 Dec;20(12):1551-1566. (PMID: 36305549)
Arch Virol. 1995;140(12):2243-54. (PMID: 8572944)
Virology. 1995 Apr 20;208(2):662-71. (PMID: 7747437)
Nature. 2022 Feb;602(7897):475-480. (PMID: 34929721)
J Neurovirol. 1999 Aug;5(4):342-54. (PMID: 10463856)
Am J Trop Med Hyg. 2002 Sep;67(3):324-34. (PMID: 12408676)
Prog Med Virol. 1967;9:176-203. (PMID: 4383416)
J Neuroimmunol. 2017 Jul 15;308:118-130. (PMID: 28501330)
Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. (PMID: 31130512)
Vaccine. 2009 Nov 5;27 Suppl 4:D80-5. (PMID: 19837294)
Nature. 2007 Nov 1;450(7166):110-4. (PMID: 17934446)
Adv Vet Sci Comp Med. 1974;18(0):79-116. (PMID: 4609399)
mBio. 2020 Feb 11;11(1):. (PMID: 32047126)
Nature. 2018 May;557(7706):570-574. (PMID: 29769725)
Vaccine. 2012 Jun 22;30(30):4532-42. (PMID: 22531556)
Microbiol Rev. 1994 Sep;58(3):491-562. (PMID: 7968923)
Viral Immunol. 2007 Spring;20(1):88-104. (PMID: 17425424)
Antiviral Res. 2012 Jun;94(3):242-57. (PMID: 22522323)
Am J Trop Med Hyg. 2011 Dec;85(6):1146-53. (PMID: 22144461)
Nat Genet. 2022 Jul;54(7):1051-1061. (PMID: 35817981)
J Gen Virol. 2015 Feb;96(Pt 2):221-238. (PMID: 25351726)
J Exp Med. 1964 Apr 1;119:547-65. (PMID: 14151098)
Nature. 2007 Jan 11;445(7124):168-76. (PMID: 17151600)
Am J Trop Med Hyg. 1985 Jan;34(1):194-202. (PMID: 3918474)
Acta Neuropathol. 1997 Apr;93(4):349-53. (PMID: 9113200)
Nature. 2021 Oct;598(7882):672-676. (PMID: 34646020)
Nucleic Acids Res. 2023 Jan 25;51(2):501-516. (PMID: 35929025)
Front Microbiol. 2016 Jun 20;7:959. (PMID: 27379085)
Front Microbiol. 2017 Feb 07;8:188. (PMID: 28223982)
Biochemistry. 2016 Mar 1;55(8):1204-13. (PMID: 26854353)
Nat Immunol. 2019 May;20(5):602-612. (PMID: 30886418)
J Virol. 2014 Sep 1;88(17):9616-23. (PMID: 24920796)
Epidemiol Rev. 2006;28:3-26. (PMID: 16763072)
Mil Med. 2005 Apr;170(4 Suppl):92-105. (PMID: 15916288)
Viruses. 2023 Jan 28;15(2):. (PMID: 36851596)
J Exp Med. 2022 Apr 4;219(4):. (PMID: 35297953)
J Virol. 2003 Sep;77(17):9278-86. (PMID: 12915543)
Nat Rev Microbiol. 2004 Oct;2(10):789-801. (PMID: 15378043)
Pathogens. 2021 Aug 03;10(8):. (PMID: 34451447)
J Virol. 2003 Nov;77(22):12022-32. (PMID: 14581539)
Annu Rev Entomol. 2004;49:141-74. (PMID: 14651460)
Am J Med Sci. 2002 Jun;323(6):316-25. (PMID: 12074486)
J Virol. 2008 Nov;82(21):10634-46. (PMID: 18768986)
Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2):84-92. (PMID: 11425168)
J Virol. 2014 Feb;88(4):2035-46. (PMID: 24307590)
Nature. 2010 Dec 2;468(7324):709-12. (PMID: 21124458)
Am J Pathol. 1973 Nov;73(2):425-42. (PMID: 4796626)
PLoS Negl Trop Dis. 2017 Aug 3;11(8):e0005693. (PMID: 28771475)
J Virol. 1996 Aug;70(8):5592-9. (PMID: 8764073)
Cell Rep. 2023 Feb 28;42(2):112126. (PMID: 36795561)
J Virol. 1993 Mar;67(3):1269-77. (PMID: 7679745)
Adv Virol. 2011;2011:249640. (PMID: 22312336)
Am J Trop Med Hyg. 1968 May;17(3):432-40. (PMID: 5690051)
Front Cell Neurosci. 2016 Aug 22;10:203. (PMID: 27597818)
Biochemistry (Mosc). 2009 Dec;74(12):1328-36. (PMID: 19961413)
Vet Microbiol. 2010 Jan 27;140(3-4):281-6. (PMID: 19775836)
PLoS Pathog. 2019 Dec 2;15(12):e1008157. (PMID: 31790515)
Nature. 2020 Dec;588(7837):308-314. (PMID: 33208938)
Annu Rev Immunol. 2022 Apr 26;40:615-649. (PMID: 35134315)
Nature. 2021 Oct;598(7882):677-681. (PMID: 34646021)
Am J Trop Med Hyg. 1969 Mar;18(2):290-6. (PMID: 5777742)
Ann Clin Microbiol Antimicrob. 2020 May 19;19(1):19. (PMID: 32429942)
Virus Res. 2006 Sep;120(1-2):107-12. (PMID: 16621103)
Immunol Rev. 2008 Oct;225:27-45. (PMID: 18837774)
Virology. 1985 Apr 30;142(2):347-56. (PMID: 2414905)
Science. 2014 Feb 14;343(6172):783-7. (PMID: 24482115)
Virology. 1995 Feb 1;206(2):994-1006. (PMID: 7856110)
Vet Immunol Immunopathol. 2003 Aug 15;94(3-4):185-90. (PMID: 12909414)
Virology. 2000 Oct 10;276(1):93-103. (PMID: 11021998)
Vet Pathol. 2010 Sep;47(5):790-805. (PMID: 20551475)
J Virol. 2016 May 27;90(12):5785-96. (PMID: 27053560)
Bull Pan Am Health Organ. 1976;10(1):46-57. (PMID: 949558)
J Immunol. 1982 Dec;129(6):2763-7. (PMID: 6183343)
J Virol. 2011 Oct;85(20):10682-90. (PMID: 21849461)
J Infect Dis. 1979 Nov;140(5):708-15. (PMID: 528788)
J Neurosci. 2005 Aug 10;25(32):7289-98. (PMID: 16093378)
Cell. 2018 Feb 22;172(5):1091-1107.e17. (PMID: 29474909)
Emerg Infect Dis. 2007 Aug;13(8):1158-65. (PMID: 17953085)
J Virol. 2009 Dec;83(23):12432-42. (PMID: 19793821)
J Neurosci. 2005 Nov 2;25(44):10064-73. (PMID: 16267213)
J Virol. 2007 Mar;81(5):2472-84. (PMID: 17108023)
Future Virol. 2011;6(6):721-740. (PMID: 21765860)
Sci Adv. 2021 Jul 28;7(31):. (PMID: 34321199)
Mol Brain. 2021 Feb 17;14(1):36. (PMID: 33618751)
Nature. 2010 Jun 24;465(7301):1079-83. (PMID: 20577213)
Open Forum Infect Dis. 2020 Aug 20;7(9):ofaa359. (PMID: 33005697)
Virology. 1982 Apr 30;118(2):269-78. (PMID: 6178209)
Vaccine. 2007 Oct 10;25(41):7017-30. (PMID: 17728025)
Front Neurosci. 2021 Mar 30;15:659601. (PMID: 33859549)
J Virol. 2004 Jan;78(1):1-8. (PMID: 14671082)
Virology. 2001 Jun 5;284(2):190-202. (PMID: 11384219)
Cell. 2001 Apr 6;105(1):137-48. (PMID: 11301009)
Vet Pathol. 1991 Sep;28(5):410-8. (PMID: 1750167)
J Neurosci. 2011 Jul 27;31(30):10836-46. (PMID: 21795536)
Brain Pathol. 2001 Jan;11(1):44-55. (PMID: 11145203)
J Cell Biol. 2003 May 12;161(3):653-60. (PMID: 12743111)
Lancet. 1996 Aug 17;348(9025):436-40. (PMID: 8709783)
Emerg Infect Dis. 2003 Feb;9(2):161-8. (PMID: 12603985)
Virology. 1997 Jul 7;233(2):302-12. (PMID: 9217054)
EMBO J. 2011 Aug 09;30(18):3854-63. (PMID: 21829169)
Biomed Sci. 1991;2(6):607-14. (PMID: 1841630)
Am J Trop Med Hyg. 1976 Nov;25(6):891-9. (PMID: 1008132)
Mol Brain. 2018 May 2;11(1):25. (PMID: 29720228)
J Virol. 2010 Jan;84(2):1014-25. (PMID: 19889755)
Am J Trop Med Hyg. 1998 Jul;59(1):100-7. (PMID: 9684636)
Vaccine. 1996 Mar;14(4):337-43. (PMID: 8744562)
معلومات مُعتمدة: F30 AI164842 United States AI NIAID NIH HHS; R01 AI014367 United States AI NIAID NIH HHS; R01 AI164653 United States AI NIAID NIH HHS; T32 AI007172 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: CP: Microbiology; alphavirus, pathogenesis, receptor, tropism, brain, mice, animal model, infection, neuron
المشرفين على المادة: 0 (Receptors, LDL)
تواريخ الأحداث: Date Created: 20230809 Date Completed: 20230926 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10529316
DOI: 10.1016/j.celrep.2023.112946
PMID: 37556325
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2023.112946