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Healthy ageing and cognitive impairment alter EEG functional connectivity in distinct frequency bands.

التفاصيل البيبلوغرافية
العنوان: Healthy ageing and cognitive impairment alter EEG functional connectivity in distinct frequency bands.
المؤلفون: Kumar WS; Centre for Neuroscience, Indian Institute of Science, Bengaluru, India., Ray S; Centre for Neuroscience, Indian Institute of Science, Bengaluru, India.
المصدر: The European journal of neuroscience [Eur J Neurosci] 2023 Sep; Vol. 58 (6), pp. 3432-3449. Date of Electronic Publication: 2023 Aug 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-
مواضيع طبية MeSH: Healthy Aging* , Cognitive Dysfunction* , Cognition Disorders* , Alzheimer Disease*, Humans ; Aged ; Brain ; Electroencephalography/methods
مستخلص: Functional connectivity (FC) indicates the interdependencies between brain signals recorded from spatially distinct locations in different frequency bands, which is modulated by cognitive tasks and is known to change with ageing and cognitive disorders. Recently, the power of narrow-band gamma oscillations induced by visual gratings have been shown to reduce with both healthy ageing and in subjects with mild cognitive impairment (MCI). However, the impact of ageing/MCI on stimulus-induced gamma FC has not been well studied. We recorded electroencephalogram (EEG) from a large cohort (N = 229) of elderly subjects (>49 years) while they viewed large cartesian gratings to induce gamma oscillations and studied changes in alpha and gamma FC with healthy ageing (N = 218) and MCI (N = 11). Surprisingly, we found distinct differences across age and MCI groups in power and FC. With healthy ageing, alpha power did not change but FC decreased significantly. MCI reduced gamma but not alpha FC significantly compared with age and gender matched controls, even when power was matched between the two groups. Overall, our results suggest distinct effects of ageing and disease on EEG power and FC, suggesting different mechanisms underlying ageing and cognitive disorders.
(© 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: Alzheimer's disease; EEG; cluster shrinkage; functional connectivity; gamma oscillations; healthy ageing
تواريخ الأحداث: Date Created: 20230810 Date Completed: 20230920 Latest Revision: 20230920
رمز التحديث: 20231215
DOI: 10.1111/ejn.16114
PMID: 37559505
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-9568
DOI:10.1111/ejn.16114