دورية أكاديمية
أعرض في EDS

Harnessing developmental cues for cardiomyocyte production.

التفاصيل البيبلوغرافية
العنوان: Harnessing developmental cues for cardiomyocyte production.
المؤلفون: Maas RGC; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University Utrecht, Experimental Cardiology Laboratory, Department of Cardiology, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands., van den Dolder FW; Amsterdam Cardiovascular Sciences, Department of Physiology, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands., Yuan Q; Amsterdam Cardiovascular Sciences, Department of Physiology, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands., van der Velden J; Amsterdam Cardiovascular Sciences, Department of Physiology, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands., Wu SM; Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Sluijter JPG; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University Utrecht, Experimental Cardiology Laboratory, Department of Cardiology, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands., Buikema JW; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University Utrecht, Experimental Cardiology Laboratory, Department of Cardiology, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.; Amsterdam Cardiovascular Sciences, Department of Physiology, Vrije Universiteit Amsterdam, Amsterdam University Medical Centers, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands.; Department of Cardiology, Amsterdam Heart Center, Amsterdam University Medical Centers, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.
المصدر: Development (Cambridge, England) [Development] 2023 Aug 01; Vol. 150 (15). Date of Electronic Publication: 2023 Aug 10.
نوع المنشور: Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge Eng : Company Of Biologists Limited
Original Publication: [Cambridge] : Company of Biologists, [c1987-
مواضيع طبية MeSH: Myocytes, Cardiac*/metabolism , Cues*, Mice ; Animals ; Heart ; Myocardium ; Signal Transduction ; Hippo Signaling Pathway ; Cell Proliferation
مستخلص: Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this improved understanding, no clinically relevant therapies are yet available to compensate for the loss of functional adult myocardium and the absence of mature cardiomyocyte renewal that underlies cardiomyopathies of multiple origins. It remains of great interest to understand which mechanisms are responsible for the decline in proliferation in adult hearts and to elucidate new strategies for the stimulation of cardiac regeneration. Multiple signaling pathways have been identified that regulate the proliferation of cardiomyocytes in the embryonic heart and appear to be upregulated in postnatal injured hearts. In this Review, we highlight the interaction of signaling pathways in heart development and discuss how this knowledge has been translated into current technologies for cardiomyocyte production.
Competing Interests: Competing interests J.W.B. and S.M.W. hold a patent on the expansion of hiPSC-derived cardiomyocytes.
(© 2023. Published by The Company of Biologists Ltd.)
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معلومات مُعتمدة: RM1 GM131981 United States GM NIGMS NIH HHS; International ERC_ European Research Council; 91818602 VICI Netherlands ZONMW_ ZonMw; 1RM1GM131981-03 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Cardiomyocyte production; Cardiomyocyte proliferation; Cardiomyocyte self-renewal; Embryonic growth pathways; Fetal gene program; Heart regeneration; Hippo signaling; Wnt signaling; hiPSC-CM
تواريخ الأحداث: Date Created: 20230810 Date Completed: 20230811 Latest Revision: 20240811
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC10445742
DOI: 10.1242/dev.201483
PMID: 37560977
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9129
DOI:10.1242/dev.201483