دورية أكاديمية
DNA methylation networks underlying mammalian traits.
| العنوان: | DNA methylation networks underlying mammalian traits. |
|---|---|
| المؤلفون: | Haghani A; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Altos Labs, San Diego, CA, USA., Li CZ; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.; Janssen Research & Development, Spring House, PA, USA., Robeck TR; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA., Zhang J; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Altos Labs, San Diego, CA, USA., Ablaeva J; Department of Biology, University of Rochester, Rochester, NY, USA., Acosta-Rodríguez VA; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Adams DM; Department of Biology, University of Maryland, College Park, MD, USA., Alagaili AN; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia., Almunia J; Loro Parque Fundacion, Avenida Loro Parque, Puerto de la Cruz, Tenerife, Spain., Aloysius A; Department of Biology, University of Kentucky, Lexington, KY, USA., Amor NMS; Laboratory of Biodiversity, Parasitology, and Ecology, University of Tunis El Manar, Tunis, Tunisia., Ardehali R; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Arneson A; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Baker CS; Marine Mammal Institute, Oregon State University, Newport, OR, USA., Banks G; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK., Belov K; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia., Bennett NC; Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Black P; Busch Gardens Tampa, Tampa, FL, USA., Blumstein DT; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA.; The Rocky Mountain Biological Laboratory, Crested Butte, CO, USA., Bors EK; Marine Mammal Institute, Oregon State University, Newport, OR, USA., Breeze CE; Altius Institute for Biomedical Sciences, Seattle, WA, USA., Brooke RT; Epigenetic Clock Development Foundation, Los Angeles, CA, USA., Brown JL; Center for Species Survival, Smithsonian National Zoo and Conservation Biology, Front Royal, VA, USA., Carter G; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA., Caulton A; AgResearch, Invermay Agricultural Centre, Mosgiel, Otago, New Zealand.; Department of Biochemistry, University of Otago, Dunedin, Otago, New Zealand., Cavin JM; Gulf World Marine Park - Dolphin Company, Panama City Beach, FL, USA., Chakrabarti L; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK., Chatzistamou I; Department of Pathology, Microbiology & Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA., Chavez AS; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.; Translational Data Analytics Institute, The Ohio State University, Columbus, OH, USA., Chen H; Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, USA., Cheng K; Medical Informatics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Chiavellini P; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Choi OW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Clarke S; AgResearch, Invermay Agricultural Centre, Mosgiel, Otago, New Zealand., Cook JA; University of New Mexico, Department of Biology and Museum of Southwestern Biology, Albuquerque, NM, USA., Cooper LN; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, USA., Cossette ML; Department of Environmental & Life Sciences, Trent University, Peterborough, Ontario, Canada., Day J; Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia., DeYoung J; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Dirocco S; SeaWorld Orlando, Orlando, FL, USA., Dold C; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA., Dunnum JL; University of New Mexico, Department of Biology and Museum of Southwestern Biology, Albuquerque, NM, USA., Ehmke EE; Duke Lemur Center, Durham, NC, USA., Emmons CK; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Emmrich S; Department of Biology, University of Rochester, Rochester, NY, USA., Erbay E; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Erlacher-Reid C; SeaWorld Orlando, Orlando, FL, USA., Faulkes CG; School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK., Fei Z; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.; Department of Statistics, University of California, Riverside, CA, USA., Ferguson SH; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Fisheries and Oceans Canada, Winnipeg, Manitoba, Canada., Finno CJ; Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, CA, USA., Flower JE; Mystic Aquarium, Mystic, CT, USA., Gaillard JM; University of Lyon, CNRS, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France., Garde E; Greenland Institute of Natural Resources, Nuuk, Greenland., Gerber L; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales, Australia.; Australian National Wildlife Collection, CSIRO, Canberra, Australia., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Goya RG; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Grant MJ; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Green CB; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanson MB; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Hart DW; Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Haulena M; Vancouver Aquarium, Vancouver, British Columbia, Canada., Herrick K; SeaWorld San Diego, San Diego, CA, USA., Hogan AN; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Hogg CJ; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia., Hore TA; Department of Anatomy, University of Otago, Dunedin, New Zealand., Huang T; Division of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA., Izpisua Belmonte JC; Altos Labs, San Diego, CA, USA., Jasinska AJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Molecular Genetics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland., Jones G; School of Biological Sciences, University of Bristol, Bristol, UK., Jourdain E; Norwegian Orca Survey, Andenes, Norway., Kashpur O; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA., Katcher H; Yuvan Research, Mountain View, CA, USA., Katsumata E; Kamogawa Sea World, Kamogawa, Chiba, Japan., Kaza V; Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA., Kiaris H; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Kobor MS; Edwin S. H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada., Kordowitzki P; Institute of Veterinary Medicine, Nicolaus Copernicus University, Torun, Poland., Koski WR; LGL Limited, King City, Ontario, Canada., Krützen M; Evolutionary Genetics Group, Department of Anthropology, University of Zurich, Zurich, Switzerland., Kwon SB; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Larison B; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA.; Center for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, Los Angeles, CA, USA., Lee SG; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lehmann M; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina., Lemaître JF; University of Lyon, CNRS, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France., Levine AJ; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Li X; Technology Center for Genomics and Bioinformatics, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Li C; Texas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources, Laramie, WY, USA., Lim AR; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Lin DTS; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Lindemann DM; SeaWorld Orlando, Orlando, FL, USA., Liphardt SW; Biology Department, University of New Mexico, Albuquerque, NM, USA., Little TJ; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Macoretta N; Department of Biology, University of Rochester, Rochester, NY, USA., Maddox D; White Oak Conservation Center, Yulee, FL, USA., Matkin CO; North Gulf Oceanic Society, Homer, AK, USA., Mattison JA; Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., McClure M; ABS Global, DeForest, WI, USA., Mergl J; Marineland of Canada, Niagara Falls, Ontario, Canada., Meudt JJ; Biomedical and Genomic Research Group, Department of Animal and Dairy Sciences, University of Wisconsin Madison, Madison, WI, USA., Montano GA; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA., Mozhui K; Department of Preventive Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA., Munshi-South J; Louis Calder Center - Biological Field Station, Department of Biological Sciences, Fordham University, Armonk, NY, USA., Murphy WJ; Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.; Interdisciplinary Program in Genetics and Genomics, Texas A&M University, College Station, TX, USA., Naderi A; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Nagy M; Museum fur Naturkunde, Leibniz-Institute for Evolution and Biodiversity Science, Berlin, Germany., Narayan P; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Nathanielsz PW; Texas Pregnancy and Life-course Health Center, Southwest National Primate Research Center, San Antonio, TX, USA.; Department of Animal Science, College of Agriculture and Natural Resources, Laramie, WY, USA., Nguyen NB; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Niehrs C; Institute of Molecular Biology (IMB), Mainz, Germany.; Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany., Nyamsuren B; Mammalogical Society of Mongolia, Ulaanbaatar, Mongolia., O'Brien JK; Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia., Ginn PO; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA., Odom DT; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Deutsches Krebsforschungszentrum, Division of Regulatory Genomics and Cancer Evolution, Heidelberg, Germany., Ophir AG; Department of Psychology, Cornell University, Ithaca, NY, USA., Osborn S; SeaWorld San Antonio, San Antonio, TX, USA., Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Parsons KM; Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, WA, USA., Paul KC; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Pedersen AB; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Pellegrini M; Department Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA., Peters KJ; Evolutionary Genetics Group, Department of Anthropology, University of Zurich, Zurich, Switzerland.; School of Earth, Atmospheric and Life Sciences, University of Wollongong, Wollongong, New South Wales, Australia., Petersen JL; Department of Animal Science, University of Nebraska, Lincoln, NE, USA., Pietersen DW; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa., Pinho GM; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA., Plassais J; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Prado NA; Department of Biology, College of Arts and Science, Adelphi University, Garden City, NY, USA.; Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA, USA., Reddy P; Altos Labs, San Diego, CA, USA.; Salk Institute for Biological Studies, La Jolla, CA, USA., Rey B; University of Lyon, CNRS, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France., Ritz BR; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.; Department of Environmental Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Robbins J; Center for Coastal Studies, Provincetown, MA, USA., Rodriguez M; Miami Seaquarium, Miami, FL, USA., Russell J; SeaWorld San Antonio, San Antonio, TX, USA., Rydkina E; Department of Biology, University of Rochester, Rochester, NY, USA., Sailer LL; Department of Psychology, Cornell University, Ithaca, NY, USA., Salmon AB; The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, UT Health San Antonio, and the Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA., Sanghavi A; Yuvan Research, Mountain View, CA, USA., Schachtschneider KM; Department of Radiology, University of Illinois at Chicago, Chicago, IL, USA.; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA.; National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Schmitt D; College of Agriculture, Missouri State University, Springfield, MO, USA., Schmitt T; SeaWorld San Diego, San Diego, CA, USA., Schomacher L; Institute of Molecular Biology (IMB), Mainz, Germany., Schook LB; Department of Radiology, University of Illinois at Chicago, Chicago, IL, USA.; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Sears KE; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA., Seifert AW; Department of Biology, University of Kentucky, Lexington, KY, USA., Shafer ABA; Department of Forensic Science, Environmental & Life Sciences, Trent University, Peterborough, Ontario, Canada., Shindyapina AV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Simmons M; Duke Lemur Center, Durham, NC, USA., Singh K; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM'S NMIMS University, Mumbai, India., Sinha I; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA., Slone J; Division of Human Genetics, Department of Pediatrics, University at Buffalo, Buffalo, NY, USA., Snell RG; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Soltanmohammadi E; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA., Spangler ML; Department of Animal Science, University of Nebraska, Lincoln, NE, USA., Spriggs M; Busch Gardens Tampa, Tampa, FL, USA., Staggs L; SeaWorld Orlando, Orlando, FL, USA., Stedman N; Busch Gardens Tampa, Tampa, FL, USA., Steinman KJ; Species Preservation Laboratory, SeaWorld San Diego, San Diego, CA, USA., Stewart DT; Biology Department, Acadia University, Wolfville, Nova Scotia, Canada., Sugrue VJ; Department of Anatomy, University of Otago, Dunedin, New Zealand., Szladovits B; Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK., Takahashi JS; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA., Takasugi M; Department of Biology, University of Rochester, Rochester, NY, USA., Teeling EC; School of Biology and Environmental Science, University College Dublin, Belfield, Dublin, Ireland., Thompson MJ; Department Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA., Van Bonn B; Animal Care and Science Division, John G. Shedd Aquarium, Chicago, IL, USA., Vernes SC; School of Biology, The University of St. Andrews, Fife, UK.; Neurogenetics of Vocal Communication Group, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands., Villar D; Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Vinters HV; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Vu H; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Wallingford MC; Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA., Wang N; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Wilkinson GS; Department of Biology, University of Maryland, College Park, MD, USA., Williams RW; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA., Yan Q; Altos Labs, San Diego, CA, USA.; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA., Yao M; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA., Young BG; Fisheries and Oceans Canada, Winnipeg, Manitoba, Canada., Zhang B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zhang Z; Department of Biology, University of Rochester, Rochester, NY, USA., Zhao Y; Department of Biology, University of Rochester, Rochester, NY, USA., Zhao P; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA., Zhou W; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zoller JA; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA., Ernst J; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Seluanov A; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Gorbunova V; Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Raj K; Altos Labs, Cambridge, UK., Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Altos Labs, San Diego, CA, USA.; Altos Labs, Cambridge, UK. |
| المصدر: | Science (New York, N.Y.) [Science] 2023 Aug 11; Vol. 381 (6658), pp. eabq5693. Date of Electronic Publication: 2023 Aug 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | DNA Methylation* , Epigenesis, Genetic* , Mammals*/genetics, Adult ; Animals ; Humans ; Epigenome ; Genome ; Phylogeny |
| مستخلص: | Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species. |
| References: | Elife. 2021 Jul 06;10:. (PMID: 34227937) Geroscience. 2021 Oct;43(5):2363-2378. (PMID: 34463900) Mol Ecol Resour. 2022 Apr;22(3):1002-1015. (PMID: 34665921) Nat Commun. 2022 Jan 10;13(1):40. (PMID: 35013267) Geroscience. 2023 Dec;45(6):3187-3209. (PMID: 37493860) Genome Biol. 2022 Jan 6;23(1):9. (PMID: 34991667) Cell. 2012 Jun 8;149(6):1381-92. (PMID: 22682255) Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2120887119. (PMID: 35580182) Commun Biol. 2021 May 31;4(1):642. (PMID: 34059764) Geroscience. 2022 Jun;44(3):1825-1845. (PMID: 35449380) Evolution. 2003 Apr;57(4):717-45. (PMID: 12778543) Geroscience. 2021 Oct;43(5):2441-2453. (PMID: 34487267) Nat Commun. 2023 Jan 16;14(1):232. (PMID: 36646694) Science. 2022 Jun 10;376(6598):1192-1202. (PMID: 35511946) PLoS Comput Biol. 2011 Jan 20;7(1):e1001057. (PMID: 21283776) Nat Commun. 2021 Mar 12;12(1):1615. (PMID: 33712580) Evol Appl. 2022 Dec 15;16(1):126-133. (PMID: 36699128) Nat Aging. 2022 Jan;2(1):46-59. (PMID: 35368774) Mol Ecol Resour. 2023 Aug;23(6):1241-1256. (PMID: 36994812) Mol Ecol. 2023 Jan;32(1):152-166. (PMID: 36226847) Nucleic Acids Res. 2021 Oct 11;49(18):10800. (PMID: 34530444) Geroscience. 2021 Oct;43(5):2413-2425. (PMID: 34482522) Bioinformatics. 2014 Feb 15;30(4):523-30. (PMID: 24336805) Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3747-52. (PMID: 15007165) Geroscience. 2022 Feb;44(1):447-461. (PMID: 34698996) Nat Ecol Evol. 2022 Apr;6(4):418-426. (PMID: 35256811) Nature. 2012 Sep 6;489(7414):57-74. (PMID: 22955616) Mol Biol Evol. 2017 Jul 1;34(7):1812-1819. (PMID: 28387841) Aging Cell. 2021 May;20(5):e13349. (PMID: 33797841) Nat Aging. 2022 Mar;2(3):243-253. (PMID: 37118377) Commun Biol. 2021 Dec 17;4(1):1412. (PMID: 34921240) J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2387-2394. (PMID: 35917578) Cell. 2015 Jan 29;160(3):554-66. (PMID: 25635462) Geroscience. 2022 Apr;44(2):699-717. (PMID: 34591235) Nat Commun. 2022 Feb 10;13(1):783. (PMID: 35145108) Aging Cell. 2021 Jul;20(7):e13414. (PMID: 34118182) BMC Bioinformatics. 2008 Dec 29;9:559. (PMID: 19114008) Nat Genet. 2018 Apr;50(4):591-602. (PMID: 29610480) Elife. 2022 Apr 07;11:. (PMID: 35389339) Geroscience. 2021 Oct;43(5):2467-2483. (PMID: 34523051) Science. 2023 Aug 11;381(6658):eabq5693. (PMID: 37561875) Genome Res. 2018 Feb;28(2):145-158. (PMID: 29259021) |
| معلومات مُعتمدة: | R01 AG065403 United States AG NIA NIH HHS; R01 AG043930 United States AG NIA NIH HHS; R21 AG055841 United States AG NIA NIH HHS; 20412 United Kingdom CRUK_ Cancer Research UK; R56 AG072736 United States AG NIA NIH HHS; R01 AG050797 United States AG NIA NIH HHS; P30 AG044271 United States AG NIA NIH HHS; R56 AG076607 United States AG NIA NIH HHS; United Kingdom WT_ Wellcome Trust; R21 ES024356 United States ES NIEHS NIH HHS; U01 AG060908 United States AG NIA NIH HHS; R01 AG045795 United States AG NIA NIH HHS; P01 AG047200 United States AG NIA NIH HHS; U34 AG068482 United States AG NIA NIH HHS; R21 DE028271 United States DE NIDCR NIH HHS; R01 AG067782 United States AG NIA NIH HHS; P30 AG013319 United States AG NIA NIH HHS; R21 OD022988 United States OD NIH HHS; R01 AG072736 United States AG NIA NIH HHS |
| تواريخ الأحداث: | Date Created: 20230810 Date Completed: 20230814 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| مُعرف محوري في PubMed: | PMC11180965 |
| DOI: | 10.1126/science.abq5693 |
| PMID: | 37561875 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
|---|---|
| DOI: | 10.1126/science.abq5693 |