دورية أكاديمية
أعرض في EDS

An Antiviral Role for TRIM14 in Ebola Virus Infection.

التفاصيل البيبلوغرافية
العنوان: An Antiviral Role for TRIM14 in Ebola Virus Infection.
المؤلفون: Kuroda M; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Thackray LB; Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, Missouri, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, Missouri, USA., Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Marzi A; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; Pandemic Preparedness, Infection and Advanced Research Center, University of Tokyo, Tokyo, Japan.
المصدر: The Journal of infectious diseases [J Infect Dis] 2023 Nov 15; Vol. 228 (Suppl 7), pp. S514-S521.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: Ebolavirus*/genetics , Hemorrhagic Fever, Ebola*, Animals ; Mice ; Interferon Type I/metabolism ; Viral Proteins/metabolism
مستخلص: Ebola virus (EBOV) is a highly pathogenic virus that encodes 7 multifunctional structural proteins. Multiple host factors have been reported to interact with the EBOV proteins. Here, we found that tripartite motif-containing 14 (TRIM14), an interferon-stimulated gene that mediates cellular signaling pathways associated with type I interferon and inflammatory cytokine production, interacts with EBOV nucleoprotein to enhance interferon-β (IFN-β) and nuclear factor-κB (NF-κB) promotor activation. Moreover, TRIM14 overexpression reduced viral replication in an infectious but biologically contained EBOVΔVP30 system by approximately 10-fold without affecting viral protein expression. Furthermore, TRM14-deficient mice were more susceptible to mouse-adapted EBOV infection than wild-type mice. Our data suggest that TRIM14 is a host factor with anti-EBOV activity that limits EBOV pathogenesis.
Competing Interests: Potential conflicts of interest . Y.K. has received unrelated funding support from FUJIFILM Toyama Chemical Co. LTD, Shionogi & Co. LTD, Daiichi Sankyo Pharmaceutical, Otsuka Pharmaceutical, KM Biologics, Kyoritsu Seiyaku, Fuji Rebio, Tauns Laboratories, Inc., and FluGen.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: U19 AI106772 United States AI NIAID NIH HHS; U19AI106772 United States NH NIH HHS
فهرسة مساهمة: Keywords: Ebola virus; NF-κB; TRIM14; interferon
المشرفين على المادة: 0 (Interferon Type I)
0 (Viral Proteins)
0 (Trim14 protein, mouse)
تواريخ الأحداث: Date Created: 20230810 Date Completed: 20231130 Latest Revision: 20240213
رمز التحديث: 20240213
مُعرف محوري في PubMed: PMC10651195
DOI: 10.1093/infdis/jiad325
PMID: 37562033
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiad325