دورية أكاديمية
أعرض في EDS

Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry.

التفاصيل البيبلوغرافية
العنوان: Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry.
المؤلفون: Villaschi A; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Pagnesi M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Stolfo D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Baldetti L; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Lombardi CM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Adamo M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Loiacono F; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy., Sammartino AM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Colombo G; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Tomasoni D; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Inciardi RM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Maccallini M; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Gasparini G; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Montella M; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy., Contessi S; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Cocianni D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Perotto M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Barone G; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merlo M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Cappelletti AM; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sinagra G; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Pini D; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy. Electronic address: daniela.pini@outlook.it., Metra M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Chiarito M; Cardio Center, Humanitas Research Hospital IRCCS, Rozzano-Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
المصدر: The American journal of cardiology [Am J Cardiol] 2023 Oct 01; Vol. 204, pp. 268-275. Date of Electronic Publication: 2023 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Excerpta Medica
مواضيع طبية MeSH: Heart Failure*/epidemiology , Heart Failure*/etiology, Humans ; Prognosis ; Hospitalization ; Registries ; Stroke Volume
مستخلص: In patients with advanced heart failure (HF), defined according to the presence of at least one I-NEED-HELP criterium, the updated 2018 Heart Failure Association of the European Society of Cardiology (HFA-ESC) criteria for advanced HF identify a subgroup of patients with HF with worse prognosis, but whether ischemic etiology has a relevant prognostic impact in this very high-risk cohort is unknown. Patients from the HELP-HF registry were stratified according to ischemic etiology and presence of advanced HF based on 2018 HFA-ESC criteria. The primary end point was a composite of all-cause death and HF hospitalization at 1 year. Secondary end points were all-cause death, HF hospitalization, and cardiovascular death at 1 year. Ischemic etiology was a leading cause of HF, in both patients with advanced and nonadvanced HF (46.1% and 42.4%, respectively, p = 0.337). The risk of the primary end point (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.09 to 1.58) and all-cause mortality (HR 1.37, 95% CI 1.06 to 1.76) was increased in ischemic as compared with nonischemic patients. The risk of the primary end point was consistently higher in ischemic patients in both patients with advanced and nonadvanced HF (advanced HF, HR 1.50 95% CI 1.04 to 2.16; nonadvanced HF, HR 1.25 95% CI 1.01 to 1.56, p interaction  = 0.333), driven by an increased risk of mortality, mainly because of cardiovascular causes. In conclusion, ischemic etiology is the most common cause of HF in patients with at least one I-NEED-HELP marker and with or without advanced HF as defined by the 2018 HFA-ESC definition. In both patients with advanced and not-advanced HF, ischemic etiology carried an increased risk of worse prognosis.
Competing Interests: Declaration of Competing Interest Dr. Stolfo reports personal fees from Novartis, Merck, GSK, and Acceleron outside of the submitted work. Dr. Merlo reports personal fees from Pfizer, Novartis, Novo Nordisk, and Vifor Pharma outside of the present work. Dr. Sinagra reports consulting fees from Novartis, Impulse Dynamics, and Biotronik, and speaker and honoraria from Novartis, Bayer, AstraZeneca, Boston Scientific, Vifor Pharma, Menarini, and Akcea Therapeutics outside of the submitted work. Dr. Metra received personal consulting honoraria of minimal amount from Abbott, Amgen, Bayer, Edwards Therapeutics, LivaNova, and Vifor Pharma for participation in advisory board meetings and executive committees of clinical trials. The remaining authors have no competing interests to declare.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: advanced heart failure; coronary artery disease; heart failure; ischemic cardiomyopathy
تواريخ الأحداث: Date Created: 20230810 Date Completed: 20230904 Latest Revision: 20230905
رمز التحديث: 20231215
DOI: 10.1016/j.amjcard.2023.07.114
PMID: 37562192
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1913
DOI:10.1016/j.amjcard.2023.07.114