دورية أكاديمية
Age-related Changes in the Adrenal Cortex: Insights and Implications.
| العنوان: | Age-related Changes in the Adrenal Cortex: Insights and Implications. |
|---|---|
| المؤلفون: | Warde KM; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Smith LJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Basham KJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. |
| المصدر: | Journal of the Endocrine Society [J Endocr Soc] 2023 Jul 20; Vol. 7 (9), pp. bvad097. Date of Electronic Publication: 2023 Jul 20 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : Endocrine Society, [2017]- |
| مستخلص: | Aging is characterized by a gradual decline in physiological function. This process affects all organs including the adrenal cortex, which normally functions to produce essential steroid hormones including mineralocorticoids, glucocorticoids, and androgens. With increasing age, features such as reduced adrenal cortex size, altered zonation, and increased myeloid immune cell infiltration substantially alter the structure and function of the adrenal cortex. Many of these hallmark features of adrenal cortex aging occur both in males and females, yet are more enhanced in males. Hormonally, a substantial reduction in adrenal androgens is a key feature of aging, which is accompanied by modest changes in aldosterone and cortisol. These hormonal changes are associated with various pathological consequences including impaired immune responses, decreased bone health, and accelerated age-related diseases. One of the most notable changes with adrenal aging is the increased incidence of adrenal tumors, which is sex dimorphic with a higher prevalence in females. Increased adrenal tumorigenesis with age is likely driven by both an increase in genetic mutations as well as remodeling of the tissue microenvironment. Novel antiaging strategies offer a promising avenue to mitigate adrenal aging and alleviate age-associated pathologies, including adrenal tumors. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.) |
| References: | Clin Endocrinol (Oxf). 2000 Dec;53(6):739-47. (PMID: 11155097) Drug Des Devel Ther. 2020 May 04;14:1693-1704. (PMID: 32440095) Eur J Endocrinol. 2010 May;162(5):919-23. (PMID: 20164211) Cancer Cell. 2016 May 9;29(5):723-736. (PMID: 27165744) Lancet Diabetes Endocrinol. 2020 Nov;8(11):894-902. (PMID: 33065059) Biol Psychiatry. 1989 Feb 1;25(3):305-19. (PMID: 2914154) Endocr Connect. 2020 Dec;9(12):1212-1220. (PMID: 33112833) Hypertension. 2020 Mar;75(3):634-644. (PMID: 31957522) Nat Genet. 2014 Jun;46(6):607-12. (PMID: 24747642) Lancet. 2009 Oct 3;374(9696):1196-208. (PMID: 19801098) Nature. 2021 Jun;594(7861):100-105. (PMID: 33981041) J Clin Endocrinol Metab. 2022 May 17;107(6):1679-1685. (PMID: 35254428) Cell. 2019 Oct 31;179(4):813-827. (PMID: 31675495) Osteoporos Int. 2002 Oct;13(10):777-87. (PMID: 12378366) Aging Cell. 2005 Dec;4(6):291-8. (PMID: 16300481) J Clin Endocrinol Metab. 2019 Nov 1;104(11):5642-5650. (PMID: 31219569) Neuroendocrinology. 2017;104(1):72-84. (PMID: 26895241) Br J Cancer. 2019 Aug;121(5):384-394. (PMID: 31363169) Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838) Curr Opin Microbiol. 2016 Feb;29:63-7. (PMID: 26673958) Aging Cell. 2010 Apr;9(2):147-61. (PMID: 20047574) Anat Rec. 1953 Mar;115(3):459-83. (PMID: 13031138) Hum Mol Genet. 2017 Sep 15;26(18):3495-3507. (PMID: 28911199) Eur J Endocrinol. 2021 May;184(5):637-645. (PMID: 33635829) Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12265-E12274. (PMID: 30541888) Nat Commun. 2021 Jan 4;12(1):49. (PMID: 33397961) Toxicol Sci. 2004 Nov;82(1):70-9. (PMID: 15319488) Ann Endocrinol (Paris). 2006 Mar;67(1):32-8. (PMID: 16596055) J Biol Chem. 1998 Jan 23;273(4):1998-2007. (PMID: 9442036) Nature. 2011 Nov 02;479(7372):232-6. (PMID: 22048312) Trends Cell Biol. 2018 Jun;28(6):436-453. (PMID: 29477613) J Gerontol. 1963 Jul;18:227-34. (PMID: 14044072) J Neurosci. 1994 May;14(5 Pt 1):2893-903. (PMID: 8182446) J Clin Endocrinol Metab. 2021 Apr 23;106(5):1389-1397. (PMID: 33524149) Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349) Cell Rep. 2022 Jun 14;39(11):110949. (PMID: 35705045) Nihon Juigaku Zasshi. 1986 Aug;48(4):719-28. (PMID: 3761780) Reproduction. 2016 Sep;152(3):245-260. (PMID: 27491879) Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90. (PMID: 19955443) Eur J Endocrinol. 2017 Apr;176(4):471-480. (PMID: 28223394) J Clin Endocrinol Metab. 1997 Nov;82(11):3898-901. (PMID: 9360559) Annu Rev Immunol. 2019 Apr 26;37:269-293. (PMID: 30649988) Sci Adv. 2022 Oct 14;8(41):eadd0422. (PMID: 36240276) J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. (PMID: 20974732) Sci Adv. 2021 Jan 27;7(5):. (PMID: 33571131) Dis Model Mech. 2023 Jun 1;16(6):. (PMID: 37102205) J Ultrastruct Res. 1971 Jan;34(1):23-71. (PMID: 4321989) Front Neuroendocrinol. 2009 Jan;30(1):65-91. (PMID: 19063914) Age (Dordr). 2010 Dec;32(4):451-66. (PMID: 20508994) Am J Pathol. 2007 Jul;171(1):2-8. (PMID: 17591947) Biomedicines. 2021 May 18;9(5):. (PMID: 34070051) Biochim Biophys Acta. 1992 Sep 24;1132(2):168-76. (PMID: 1382606) J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):394-400. (PMID: 31714574) Endocrinology. 2015 Dec;156(12):4592-603. (PMID: 26305888) Nat Aging. 2021 May;1(5):454-472. (PMID: 34263179) Nat Med. 2003 Nov;9(11):1390-7. (PMID: 14566334) Aging Cell. 2020 Feb;19(2):e13083. (PMID: 31808308) Aging Cell. 2005 Dec;4(6):319-24. (PMID: 16300484) J Exp Med. 1988 May 1;167(5):1708-12. (PMID: 3259257) Arch Histol Jpn. 1979 Apr;42(2):95-102. (PMID: 464752) Philos Trans R Soc Lond B Biol Sci. 2021 Apr 26;376(1823):20200207. (PMID: 33678029) J Endocrinol. 2009 Jul;202(1):99-109. (PMID: 19403566) Cell Metab. 2023 Apr 4;35(4):667-684.e6. (PMID: 37019080) J Gerontol. 1993 May;48(3):M72-7. (PMID: 8387077) Mol Cell Biol. 2008 Dec;28(23):7030-40. (PMID: 18809574) J Clin Endocrinol Metab. 2005 Nov;90(11):6283-9. (PMID: 16091484) J Endocrinol. 2019 Apr;241(1):R51-R63. (PMID: 30817316) Geroscience. 2023 Feb;45(1):385-397. (PMID: 35974129) Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E139-46. (PMID: 17374700) Br J Pharmacol. 2017 Mar;174(5):396-408. (PMID: 28012176) Nat Med. 2015 Dec;21(12):1424-35. (PMID: 26646499) J Clin Endocrinol Metab. 2021 Jan 1;106(1):42-54. (PMID: 32717746) Am J Pathol. 1950 Mar;26(2):211-33. (PMID: 15406252) Anat Rec. 1960 Feb;136:117-26. (PMID: 14441598) Exp Gerontol. 1987;22(2):127-37. (PMID: 3622652) Endocr Rev. 2014 Apr;35(2):282-326. (PMID: 24423978) Trends Cell Biol. 2001 Nov;11(11):S27-31. (PMID: 11684439) J Endocrinol. 2006 Oct;191(1):301-8. (PMID: 17065412) Cell Tissue Res. 1983;232(2):457-69. (PMID: 6883453) J Exp Med. 1941 Jun 30;74(1):1-8. (PMID: 19871112) Neurology. 2017 Jan 24;88(4):371-378. (PMID: 27986873) Endocr Rev. 2015 Oct;36(5):526-63. (PMID: 26213785) J Am Geriatr Soc. 2008 Jun;56(6):994-8. (PMID: 18422949) Hypertension. 2003 Nov;42(5):952-5. (PMID: 14569002) Exp Gerontol. 2000 May;35(3):401-8. (PMID: 10832059) Nat Med. 2022 Aug;28(8):1556-1568. (PMID: 35953721) J Endocrinol. 1973 Dec;59(3):451-9. (PMID: 4761681) Arthritis Res Ther. 2015 Mar 11;17:56. (PMID: 25890314) Eur J Endocrinol. 2023 Apr 5;188(4):R98-R109. (PMID: 37041725) Aging (Albany NY). 2016 Jan;8(1):3-11. (PMID: 26805432) Genes Dev. 2020 Dec 1;34(23-24):1565-1576. (PMID: 33262144) Nat Aging. 2023 Jul;3(7):846-865. (PMID: 37231196) Breast Cancer Res. 2017 Mar 24;19(1):35. (PMID: 28340615) Cell Rep. 2023 Jan 31;42(1):111982. (PMID: 36640301) Cell Stem Cell. 2019 Aug 1;25(2):290-296.e2. (PMID: 31104943) Oncogene. 2017 Aug;36(31):4445-4456. (PMID: 28368424) Endocrinology. 2018 Jul 1;159(7):2596-2613. (PMID: 29767714) EMBO J. 2021 Jan 4;40(1):e105242. (PMID: 33215738) Eur J Endocrinol. 2016 Aug;175(2):G1-G34. (PMID: 27390021) Mech Ageing Dev. 1985 May 13;30(2):123-42. (PMID: 3894818) Nat Commun. 2016 Sep 14;7:12751. (PMID: 27624192) Dev Cell. 2013 Sep 30;26(6):666-673. (PMID: 24035414) Jpn J Surg. 1991 Sep;21(5):494-8. (PMID: 1813685) Hum Mol Genet. 2010 Apr 15;19(8):1561-76. (PMID: 20106872) Mol Cell Endocrinol. 2011 Mar 15;335(1):2-13. (PMID: 20398732) Exp Anim. 1997 Oct;46(4):303-6. (PMID: 9353639) Circulation. 2017 Jul 25;136(4):347-355. (PMID: 28566337) Aging Cell. 2012 Oct;11(5):867-75. (PMID: 22708967) Aging Cell. 2012 Aug;11(4):675-82. (PMID: 22587563) Proc Natl Acad Sci U S A. 1984 Jul;81(13):4174-7. (PMID: 6377311) Nat Rev Endocrinol. 2013 Apr;9(4):205-15. (PMID: 23438832) J Clin Endocrinol Metab. 2020 Aug 1;105(8):. (PMID: 32498089) Eur J Endocrinol. 2023 Jan 10;188(1):. (PMID: 36651154) Cell. 2013 Nov 21;155(5):1119-30. (PMID: 24238961) N Engl J Med. 2006 Oct 19;355(16):1647-59. (PMID: 17050889) J Invest Dermatol. 2011 Jan;131(1):30-6. (PMID: 20739946) J Clin Endocrinol Metab. 2019 Jul 1;104(7):2615-2622. (PMID: 30753518) J Clin Endocrinol Metab. 2023 Jul 14;108(8):1835-1874. (PMID: 37326526) J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):M1-7. (PMID: 9008662) J Gerontol. 1967 Jul;22(3):253-67. (PMID: 6028494) Endocrinology. 2002 Oct;143(10):4031-7. (PMID: 12239114) Int J Mol Sci. 2021 May 05;22(9):. (PMID: 34063067) Genes Dev. 2019 Feb 1;33(3-4):209-220. (PMID: 30692207) J Clin Endocrinol Metab. 2020 Mar 1;105(3):. (PMID: 31745564) Mol Cell Endocrinol. 2021 May 15;528:111239. (PMID: 33676986) PLoS One. 2022 Dec 30;17(12):e0279682. (PMID: 36584094) Z Zellforsch Mikrosk Anat. 1968;87(3):315-29. (PMID: 4179076) J Mol Neurosci. 2002 Aug-Oct;19(1-2):201-6. (PMID: 12212781) Q J Microsc Sci. 1948 Mar;89(Pt 1):53-74. (PMID: 18860294) BMC Vet Res. 2016 Aug 03;12(1):161. (PMID: 27487830) J Biol Chem. 2021 Nov;297(5):101229. (PMID: 34599964) Lancet Diabetes Endocrinol. 2022 Jul;10(7):499-508. (PMID: 35533704) Cancer Discov. 2022 Jan;12(1):31-46. (PMID: 35022204) Nat Rev Endocrinol. 2018 Oct;14(10):576-590. (PMID: 30046148) Endocr Pathol. 1998 Autumn;9(3):235-239. (PMID: 12114714) Aging Cell. 2012 Aug;11(4):569-78. (PMID: 22404905) Atherosclerosis. 2022 Aug;355:76-82. (PMID: 35803767) Clin Endocrinol (Oxf). 1998 Sep;49(3):311-6. (PMID: 9861321) Cell. 2013 Nov 21;155(5):1104-18. (PMID: 24238962) Endocrinology. 2011 Sep;152(9):3430-9. (PMID: 21733829) J Endocr Soc. 2017 May 12;1(7):787-799. (PMID: 29264530) Exp Eye Res. 1984 Feb;38(2):137-51. (PMID: 6714331) Elife. 2021 Mar 16;10:. (PMID: 33724179) J Clin Endocrinol Metab. 1999 Mar;84(3):1110-5. (PMID: 10084603) Front Endocrinol (Lausanne). 2021 Jan 21;11:599869. (PMID: 33584538) J Bone Miner Res. 2009 Nov;24(11):1841-6. (PMID: 19453254) Immunology. 1997 Mar;90(3):344-9. (PMID: 9155639) Cancer Res. 2023 Jul 5;83(13):2123-2141. (PMID: 37129912) J Clin Endocrinol Metab. 2000 Aug;85(8):2832-8. (PMID: 10946891) Nature. 2016 Feb 11;530(7589):184-9. (PMID: 26840489) Physiol Rev. 2019 Apr 1;99(2):1047-1078. (PMID: 30648461) Endocr Res. 2015;40(1):8-13. (PMID: 24832628) Prog Neurobiol. 2011 Sep 15;95(1):14-25. (PMID: 21740956) Trends Endocrinol Metab. 2017 Mar;28(3):199-212. (PMID: 27789101) Am J Pathol. 2012 Sep;181(3):1017-33. (PMID: 22800756) Mol Neurodegener. 2022 Jan 9;17(1):5. (PMID: 35000600) |
| فهرسة مساهمة: | Keywords: adrenal tumor; adrenocortical; aging; aging and cancer; antiaging; cellular senescence; longevity; senescence-associated secretory phenotype (SASP); sexual dimorphism; steroidogenesis |
| تواريخ الأحداث: | Date Created: 20230811 Latest Revision: 20231024 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10410302 |
| DOI: | 10.1210/jendso/bvad097 |
| PMID: | 37564884 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2472-1972 |
|---|---|
| DOI: | 10.1210/jendso/bvad097 |