دورية أكاديمية
أعرض في EDS

Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs.

التفاصيل البيبلوغرافية
العنوان: Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs.
المؤلفون: Singh S; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Zhou Y; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Farris AL; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Whitehead EC; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Nyberg EL; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., O'Sullivan AN; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Zhang NY; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Rindone AN; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Achebe CC; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Zbijewski W; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Grundy W; StageBio Company, Mount Jackson, VA, 22842, USA., Garlick D; StageBio Company, Mount Jackson, VA, 22842, USA., Jackson ND; Inotiv, Fort Collins, CO, 80524, USA., Kraitchman D; Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Izzi JM; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lopez J; Pediatric Plastic and Reconstructive Surgery, Pediatric Head and Neck Surgery, AdventHealth for Children, Orlando, FL, 32803, USA., Grant MP; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Plastic and Reconstructive Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Grayson WL; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2023 Nov; Vol. 12 (29), pp. e2301944. Date of Electronic Publication: 2023 Aug 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Tissue Scaffolds* , Printing, Three-Dimensional*, Swine ; Animals ; Swine, Miniature ; Biocompatible Materials/pharmacology ; Bone Regeneration ; Osteogenesis
مستخلص: Porous tissue-engineered 3D-printed scaffolds are a compelling alternative to autografts for the treatment of large periorbital bone defects. Matching the defect-specific geometry has long been considered an optimal strategy to restore pre-injury anatomy. However, studies in large animal models have revealed that biomaterial-induced bone formation largely occurs around the scaffold periphery. Such ectopic bone formation in the periorbital region can affect vision and cause disfigurement. To enhance anatomic reconstruction, geometric mismatches are introduced in the scaffolds used to treat full thickness zygomatic defects created bilaterally in adult Yucatan minipigs. 3D-printed, anatomically-mirrored scaffolds are used in combination with autologous stromal vascular fraction of cells (SVF) for treatment. An advanced image-registration workflow is developed to quantify the post-surgical geometric mismatch and correlate it with the spatial pattern of the regenerating bone. Osteoconductive bone growth on the dorsal and ventral aspect of the defect enhances scaffold integration with the native bone while medio-lateral bone growth leads to failure of the scaffolds to integrate. A strong positive correlation is found between geometric mismatch and orthotopic bone deposition at the defect site. The data suggest that strategic mismatch >20% could improve bone scaffold design to promote enhanced regeneration, osseointegration, and long-term scaffold survivability.
(© 2023 Wiley-VCH GmbH.)
References: Sci Transl Med. 2012 Jul 4;4(141):141ra93. (PMID: 22764209)
J Comput Assist Tomogr. 2005 May-Jun;29(3):305-10. (PMID: 15891495)
J Tissue Eng Regen Med. 2012 Feb;6(2):155-62. (PMID: 21446054)
Artif Organs. 2017 Feb;41(2):199-204. (PMID: 27401022)
Sci Rep. 2021 May 24;11(1):10797. (PMID: 34031476)
Appl Mater Today. 2019 May 30;15:377-388. (PMID: 31281871)
PLoS One. 2019 Nov 19;14(11):e0225007. (PMID: 31743350)
Nat Comput Sci. 2021 Aug;1(8):532-541. (PMID: 38217252)
Bone. 2021 Dec;153:116163. (PMID: 34461285)
Biomed Mater. 2014 Aug;9(4):045003. (PMID: 24945873)
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110289. (PMID: 31753386)
Plast Reconstr Surg Glob Open. 2018 Nov 13;6(11):e1975. (PMID: 30881789)
Sci Rep. 2016 Dec 09;6:38814. (PMID: 27934940)
Biomaterials. 2005 Sep;26(27):5474-91. (PMID: 15860204)
Adv Healthc Mater. 2020 May;9(10):e1901807. (PMID: 32324336)
Front Bioeng Biotechnol. 2022 Sep 23;10:995266. (PMID: 36213070)
J Craniomaxillofac Surg. 2013 Oct;41(7):630-6. (PMID: 23419413)
Biomaterials. 2015 Jun;52:376-84. (PMID: 25818444)
Bioact Mater. 2021 Nov 10;13:64-81. (PMID: 35224292)
Toxicol Pathol. 2019 Apr;47(3):280-296. (PMID: 30652939)
Sci Rep. 2020 Apr 27;10(1):7068. (PMID: 32341459)
J Exp Biol. 2000 Jul;203(Pt 14):2093-104. (PMID: 10862722)
Biomaterials. 2022 Mar;282:121392. (PMID: 35134701)
J Orthop Res. 2004 Mar;22(2):362-7. (PMID: 15013097)
Biomaterials. 2022 Jan;280:121318. (PMID: 34922272)
Otolaryngol Clin North Am. 2013 Oct;46(5):759-78. (PMID: 24138736)
ACS Appl Mater Interfaces. 2022 May 11;14(18):20693-20707. (PMID: 35500207)
J Craniofac Surg. 2019 Mar/Apr;30(2):e127-e131. (PMID: 30531282)
Int J Comput Assist Radiol Surg. 2019 May;14(5):763-773. (PMID: 30825070)
Tissue Eng Part A. 2018 Jun;24(11-12):943-954. (PMID: 29264958)
Biomed Mater. 2016 Feb 19;11(1):015016. (PMID: 26894676)
J Craniofac Surg. 2016 Nov;27(8):2020-2024. (PMID: 28005746)
J Biomed Mater Res A. 2010 Jan;92(1):359-68. (PMID: 19189391)
Int J Oral Sci. 2017 Sep;9(3):139-144. (PMID: 28708129)
3D Print Med. 2022 Apr 6;8(1):9. (PMID: 35384521)
Front Bioeng Biotechnol. 2022 Sep 07;10:980727. (PMID: 36159680)
Laryngoscope. 2021 Sep;131(9):1985-1989. (PMID: 33571397)
Sci Adv. 2020 Mar 20;6(12):eaaz6725. (PMID: 32219170)
معلومات مُعتمدة: R01 DE027957 United States DE NIDCR NIH HHS; R01DE027957 United States NH NIH HHS; R01DE027957 United States NH NIH HHS
فهرسة مساهمة: Keywords: 3D-printing; Yucatan pigs; bone regeneration; geometric mismatch; image registration; midfacial; scaffolds
المشرفين على المادة: 0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20230811 Date Completed: 20231123 Latest Revision: 20240206
رمز التحديث: 20240206
مُعرف محوري في PubMed: PMC10840722
DOI: 10.1002/adhm.202301944
PMID: 37565378
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202301944