دورية أكاديمية
أعرض في EDS

The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.

التفاصيل البيبلوغرافية
العنوان: The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.
المؤلفون: Ramirez I; School of Dentistry, University of São Paulo (FORP-USP), Ribeirão Preto, Brazil., Kirschneck C; Department of Orthodontics, University of Regensburg, Regensburg, Germany., Silva-Sousa AC; School of Dentistry, University of São Paulo (FORP-USP), Ribeirão Preto, Brazil., Proff P; Department of Orthodontics, University of Regensburg, Regensburg, Germany., S Antunes L; School of Dentistry, Tuiuti University from Paraná, Curitiba, Paraná, Brazil., Gabbardo MC; Department of Specific Formation, Fluminense Federal University, Nova Friburgo, Brazil., de Oliveira DS; School of Health Sciences, University Positivo (UP), Curitiba, Brazil., Sousa-Neto MD; School of Dentistry, University of São Paulo (FORP-USP), Ribeirão Preto, Brazil., Baratto-Filho F; School of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, Brazil.; Department of Dentistry, University of Joinville Region (Univille), Joinville, SC, Brazil., Küchler EC; Department of Orthodontics, University of Regensburg, Regensburg, Germany.
المصدر: PloS one [PLoS One] 2023 Aug 11; Vol. 18 (8), pp. e0288782. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Polymorphism, Single Nucleotide* , Dental Pulp Calcification*, Humans ; Cross-Sectional Studies ; Radiography, Panoramic ; Molar ; Dental Pulp ; Wnt Proteins/genetics
مستخلص: The aim of this study is to evaluate if single nucleotide polymorphisms (SNPs) in WNT6 and WNT10A are associated with the risk of dental pulp calcification in orthodontic patients. This cross-sectional study followed the "Strengthening the Reporting of Genetic Association Studies" (STREGA) guidelines. Panoramic radiographs (pre- and post-orthodontic treatment) and genomic DNA from 132 orthodontic patients were studied. Dental pulp calcification (pulp stones and/or pulp space narrowing) was recorded in upper and lower first molars. The SNPs in WNT6 and WNT10A (rs7349332, rs3806557, rs10177996, and rs6754599) were assessed through genotyping analysis using DNA extracted from buccal epithelial cells. The association between pulp calcification and SNPs were analyzed using allelic and genotypic distributions and haplotype frequencies (p<0.05). Prevalence of dental pulp calcification was 42.4% in the 490 studied molars. In the genotypic analysis, the SNPs in WNT10A showed a statistically significant value for molar calcification (p = 0.027 for rs1017799), upper molar calcification (p = 0.040 for rs1017799) (recessive model), and molar calcification (p = 0.046 for rs3806557) (recessive model). In the allelic distribution, the allele C of the SNP rs10177996 in WNT10A was associated with molar calcifications (p = 0.042) and with upper first molar calcification (p = 0.035). Nine combinations of haplotypes showed statistically significant value (p<0.05). The findings of this study indicates that SNPs in WNT10A and WNT6 are associated with dental pulp calcification in molars after orthodontic treatment and may be considered as biomarkers for dental pulp calcification.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Ramirez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
التعليقات: Erratum in: PLoS One. 2024 Jun 6;19(6):e0305377. doi: 10.1371/journal.pone.0305377. (PMID: 38843152)
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المشرفين على المادة: 0 (WNT10A protein, human)
0 (Wnt Proteins)
0 (WNT6 protein, human)
تواريخ الأحداث: Date Created: 20230811 Date Completed: 20230814 Latest Revision: 20240606
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC10420345
DOI: 10.1371/journal.pone.0288782
PMID: 37566620
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0288782