دورية أكاديمية
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Cellular and molecular mechanisms of aflatoxin B 1 -mediated neurotoxicity: The therapeutic role of natural bioactive compounds.

التفاصيل البيبلوغرافية
العنوان: Cellular and molecular mechanisms of aflatoxin B 1 -mediated neurotoxicity: The therapeutic role of natural bioactive compounds.
المؤلفون: Adedara IA; Department of Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, Camobi, 97105-900 Santa Maria, RS, Brazil; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: dedac2001@yahoo.co.uk., Atanda OE; Human Toxicology Program, Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, 52242, USA., Sant'Anna Monteiro C; Department of Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, Camobi, 97105-900 Santa Maria, RS, Brazil., Rosemberg DB; Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Camobi, 97105-900 Santa Maria, RS, Brazil., Aschner M; Department of Molecular Pharmacology; Albert Einstein College of Medicine Forchheimer 209; 1300 Morris Park Avenue, Bronx, NY 10461, USA., Farombi EO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria., Rocha JBT; Department of Biochemical and Molecular Biology, Federal University of Santa Maria, 97105-900, Santa Maria, RS, Brazil., Furian AF; Department of Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, Camobi, 97105-900 Santa Maria, RS, Brazil., Emanuelli T; Department of Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, Camobi, 97105-900 Santa Maria, RS, Brazil.
المصدر: Environmental research [Environ Res] 2023 Nov 15; Vol. 237 (Pt 1), pp. 116869. Date of Electronic Publication: 2023 Aug 09.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
مستخلص: Aflatoxin B 1 (AFB 1 ), a dietary toxin from the mold Aspergillus species, is well acknowledged to elicit extra-hepatic toxicity in both animals and humans. The neurotoxicity of AFB 1 has become a global public health concern. Contemporary research on how AFB 1 enters the brain to elicit neuronal dysregulation leading to noxious neurological outcomes has increased greatly in recent years. The current review discusses several neurotoxic outcomes and susceptible targets of AFB 1 toxicity at cellular, molecular and genetic levels. Specifically, neurotoxicity studies involving the use of brain homogenates, neuroblastoma cell line IMR-32, human brain microvascular endothelial cells, microglial cells, and astrocytes, as well as mammalian and non-mammalian models to unravel the mechanisms associated with AFB 1 exposure are highlighted. Further, some naturally occurring bioactive compounds with compelling therapeutic effects on AFB 1 -induced neurotoxicity are reviewed. In conclusion, available data from literature highlight AFB 1 as a neurotoxin and its possible pathological contribution to neurological disorders. Further mechanistic studies aimed at discovering and developing effective therapeutics for AFB 1 neurotoxicity is warranted.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Aflatoxin B(1); Bioactive compounds; Experimental models; Neurotoxicity
تواريخ الأحداث: Date Created: 20230811 Latest Revision: 20231022
رمز التحديث: 20231023
DOI: 10.1016/j.envres.2023.116869
PMID: 37567382
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0953
DOI:10.1016/j.envres.2023.116869